Anaphylaxis associated with the vaccine against measles, mumps and rubella

Detalhes bibliográficos
Autor(a) principal: Novadzki, Iolanda Maria
Data de Publicação: 2010
Outros Autores: Rosario Filho, Nelson
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/32780
Resumo: A case-control study was carried out aiming to describe the cases and causes of anaphylaxis associated with the vaccine against measles, mumps and rubella. A total of 22 reported cases in children who showed mucocutaneous manifestations, during the Campanha Nacional de Vacinação (Brazilian Vaccination Campaign), conducted in the city of Curitiba, Southern Brazil, in 2004, were studied. In addition, 66 children, who were next to these cases and did not show a symptomatology after the vaccine was applied, were selected. Serum measurements of antibodies for vaccine antigens and total IgE, specific IgE antibody measurements for several allergens, and skin tests were performed. Vaccine response was adequate, specific IgE measurement and skin tests showed that potential allergens in vaccines and atopy were not associated with anaphylactic reactions. Skin tests with the vaccine and dextran were positive in the cases exclusively, suggesting sensitization to certain residual components of the vaccine and possible cross-reaction with dextran.
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spelling Anaphylaxis associated with the vaccine against measles, mumps and rubella Anafilaxia asociada a la vacuna contra sarampión, varicela y rubéola Anafilaxia associada à vacina contra sarampo, caxumba e rubéola Vacina contra Sarampo-Caxumba-Rubéola^i1^sefeitos adverCriançaAnafilaxiaEstudos de CasosControlesVacuna contra el Sarampión-Parotiditis-Rubéola^i3^sefectos adverNiñoAnafilaxiaEstudios de CasosControlesMeasles-Mumps-Rubella Vaccine^i2^sadverse effeChildAnaphylaxisCase-Control Studies A case-control study was carried out aiming to describe the cases and causes of anaphylaxis associated with the vaccine against measles, mumps and rubella. A total of 22 reported cases in children who showed mucocutaneous manifestations, during the Campanha Nacional de Vacinação (Brazilian Vaccination Campaign), conducted in the city of Curitiba, Southern Brazil, in 2004, were studied. In addition, 66 children, who were next to these cases and did not show a symptomatology after the vaccine was applied, were selected. Serum measurements of antibodies for vaccine antigens and total IgE, specific IgE antibody measurements for several allergens, and skin tests were performed. Vaccine response was adequate, specific IgE measurement and skin tests showed that potential allergens in vaccines and atopy were not associated with anaphylactic reactions. Skin tests with the vaccine and dextran were positive in the cases exclusively, suggesting sensitization to certain residual components of the vaccine and possible cross-reaction with dextran. Estudio del tipo caso-control cuyo objetivo fue describir los casos y las causas de anafilaxia asociada a la vacuna contra sarampión, varicela y rubéola. Fueron estudiados 22 casos notificados en niños de Curitiba, Sureste de Brasil, durante Campaña Nacional de Vacunación de 2004, que presentaron manifestaciones mococutáneas. Para el control, fueron seleccionados 66 niños vecinos de los casos, que no presentaron sintomatología posterior a la aplicación vacunal. Fueron realizadas dosificaciones séricas de anticuerpos para los antígenos vacunales, IgE total y específicas para diversos alérgenos, y pruebas cutáneas. La respuesta vacunal fue adecuada, la dosificación de IgE específica y las pruebas cutáneas mostraron que los alérgenos potenciales constituyentes de la vacuna y la atopia no fueron relacionados a las reacciones anafilácticas. Las pruebas cutáneas con la vacuna y el dextrano fueron positivas solamente en los casos, sugiriendo sensibilización por algún componente residual de la vacuna y posible reacción cruzada con el dextrano. Estudo do tipo caso-controle cujo objetivo foi descrever os casos e as causas de anafilaxia associada à vacina contra sarampo, caxumba e rubéola. Foram estudados 22 casos notificados em crianças de Curitiba, PR, durante Campanha Nacional de Vacinação de 2004, que apresentaram manifestações mucocutâneas. Para o controle, foram selecionadas 66 crianças vizinhas dos casos, que não apresentaram sintomatologia após a aplicação vacinal. Foram realizadas dosagens séricas de anticorpos para os antígenos vacinais, IgE total e específicas para diversos alérgenos, e testes cutâneos. A resposta vacinal foi adequada, a dosagem de IgE específica e os testes cutâneos mostraram que os alérgenos potenciais constituintes da vacina e a atopia não foram relacionados às reações anafiláticas. Os testes cutâneos com a vacina e o dextrano foram positivos somente nos casos, sugerindo sensibilização por algum componente residual da vacina e possível reação cruzada com o dextrano. Universidade de São Paulo. Faculdade de Saúde Pública2010-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/3278010.1590/S0034-89102010000200020Revista de Saúde Pública; Vol. 44 No. 2 (2010); 372-376 Revista de Saúde Pública; Vol. 44 Núm. 2 (2010); 372-376 Revista de Saúde Pública; v. 44 n. 2 (2010); 372-376 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporenghttps://www.revistas.usp.br/rsp/article/view/32780/35272https://www.revistas.usp.br/rsp/article/view/32780/35273Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessNovadzki, Iolanda MariaRosario Filho, Nelson2012-07-10T02:18:19Zoai:revistas.usp.br:article/32780Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-07-10T02:18:19Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Anaphylaxis associated with the vaccine against measles, mumps and rubella
Anafilaxia asociada a la vacuna contra sarampión, varicela y rubéola
Anafilaxia associada à vacina contra sarampo, caxumba e rubéola
title Anaphylaxis associated with the vaccine against measles, mumps and rubella
spellingShingle Anaphylaxis associated with the vaccine against measles, mumps and rubella
Novadzki, Iolanda Maria
Vacina contra Sarampo-Caxumba-Rubéola^i1^sefeitos adver
Criança
Anafilaxia
Estudos de Casos
Controles
Vacuna contra el Sarampión-Parotiditis-Rubéola^i3^sefectos adver
Niño
Anafilaxia
Estudios de Casos
Controles
Measles-Mumps-Rubella Vaccine^i2^sadverse effe
Child
Anaphylaxis
Case-Control Studies
title_short Anaphylaxis associated with the vaccine against measles, mumps and rubella
title_full Anaphylaxis associated with the vaccine against measles, mumps and rubella
title_fullStr Anaphylaxis associated with the vaccine against measles, mumps and rubella
title_full_unstemmed Anaphylaxis associated with the vaccine against measles, mumps and rubella
title_sort Anaphylaxis associated with the vaccine against measles, mumps and rubella
author Novadzki, Iolanda Maria
author_facet Novadzki, Iolanda Maria
Rosario Filho, Nelson
author_role author
author2 Rosario Filho, Nelson
author2_role author
dc.contributor.author.fl_str_mv Novadzki, Iolanda Maria
Rosario Filho, Nelson
dc.subject.por.fl_str_mv Vacina contra Sarampo-Caxumba-Rubéola^i1^sefeitos adver
Criança
Anafilaxia
Estudos de Casos
Controles
Vacuna contra el Sarampión-Parotiditis-Rubéola^i3^sefectos adver
Niño
Anafilaxia
Estudios de Casos
Controles
Measles-Mumps-Rubella Vaccine^i2^sadverse effe
Child
Anaphylaxis
Case-Control Studies
topic Vacina contra Sarampo-Caxumba-Rubéola^i1^sefeitos adver
Criança
Anafilaxia
Estudos de Casos
Controles
Vacuna contra el Sarampión-Parotiditis-Rubéola^i3^sefectos adver
Niño
Anafilaxia
Estudios de Casos
Controles
Measles-Mumps-Rubella Vaccine^i2^sadverse effe
Child
Anaphylaxis
Case-Control Studies
description A case-control study was carried out aiming to describe the cases and causes of anaphylaxis associated with the vaccine against measles, mumps and rubella. A total of 22 reported cases in children who showed mucocutaneous manifestations, during the Campanha Nacional de Vacinação (Brazilian Vaccination Campaign), conducted in the city of Curitiba, Southern Brazil, in 2004, were studied. In addition, 66 children, who were next to these cases and did not show a symptomatology after the vaccine was applied, were selected. Serum measurements of antibodies for vaccine antigens and total IgE, specific IgE antibody measurements for several allergens, and skin tests were performed. Vaccine response was adequate, specific IgE measurement and skin tests showed that potential allergens in vaccines and atopy were not associated with anaphylactic reactions. Skin tests with the vaccine and dextran were positive in the cases exclusively, suggesting sensitization to certain residual components of the vaccine and possible cross-reaction with dextran.
publishDate 2010
dc.date.none.fl_str_mv 2010-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/32780
10.1590/S0034-89102010000200020
url https://www.revistas.usp.br/rsp/article/view/32780
identifier_str_mv 10.1590/S0034-89102010000200020
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/32780/35272
https://www.revistas.usp.br/rsp/article/view/32780/35273
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista de Saúde Pública
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista de Saúde Pública
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 44 No. 2 (2010); 372-376
Revista de Saúde Pública; Vol. 44 Núm. 2 (2010); 372-376
Revista de Saúde Pública; v. 44 n. 2 (2010); 372-376
1518-8787
0034-8910
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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