Synthesis of ordered mesoporous silica MCM-41 with controlled morphology for potential application in controlled drug delivery systems

Detalhes bibliográficos
Autor(a) principal: Oliveira,D. M.
Data de Publicação: 2019
Outros Autores: Andrada,A. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cerâmica (São Paulo. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0366-69132019000200170
Resumo: Abstract MCM-41 is one of the most studied mesoporous ceramics for drug delivery systems. Its high specific surface area and mesoporosity allow high adsorption capacity. Even though there are many studies published in the biomedical field, there are no reports of commercial applications of MCM-41 so far. One of the possible justifications is the lack of morphological control during conventional synthesis. Therefore, modifications in the reaction parameters of the MCM-41 conventional synthesis were tested in this paper, aiming to obtain particles with reduced diameter and agglomeration. It was observed that both the increase in the water molar proportion and the decrease in the stirring time resulted in particles with reduced size. Furthermore, the control of the tetraethyl orthosilicate (TEOS) dropping rate and the addition of triethylamine (TEA) improved the dispersion of the system, but they also decreased the particle size, and therefore van der Waals interactions promoted re-agglomeration.
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spelling Synthesis of ordered mesoporous silica MCM-41 with controlled morphology for potential application in controlled drug delivery systemsMCM-41controlled drug releasereduction of particle sizeincrease in dispersionAbstract MCM-41 is one of the most studied mesoporous ceramics for drug delivery systems. Its high specific surface area and mesoporosity allow high adsorption capacity. Even though there are many studies published in the biomedical field, there are no reports of commercial applications of MCM-41 so far. One of the possible justifications is the lack of morphological control during conventional synthesis. Therefore, modifications in the reaction parameters of the MCM-41 conventional synthesis were tested in this paper, aiming to obtain particles with reduced diameter and agglomeration. It was observed that both the increase in the water molar proportion and the decrease in the stirring time resulted in particles with reduced size. Furthermore, the control of the tetraethyl orthosilicate (TEOS) dropping rate and the addition of triethylamine (TEA) improved the dispersion of the system, but they also decreased the particle size, and therefore van der Waals interactions promoted re-agglomeration.Associação Brasileira de Cerâmica2019-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0366-69132019000200170Cerâmica v.65 n.374 2019reponame:Cerâmica (São Paulo. Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/0366-69132019653742509info:eu-repo/semantics/openAccessOliveira,D. M.Andrada,A. S.eng2019-06-04T00:00:00Zoai:scielo:S0366-69132019000200170Revistahttps://www.scielo.br/j/ce/PUBhttps://old.scielo.br/oai/scielo-oai.phpceram.abc@gmail.com||ceram.abc@gmail.com1678-45530366-6913opendoar:2019-06-04T00:00Cerâmica (São Paulo. Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Synthesis of ordered mesoporous silica MCM-41 with controlled morphology for potential application in controlled drug delivery systems
title Synthesis of ordered mesoporous silica MCM-41 with controlled morphology for potential application in controlled drug delivery systems
spellingShingle Synthesis of ordered mesoporous silica MCM-41 with controlled morphology for potential application in controlled drug delivery systems
Oliveira,D. M.
MCM-41
controlled drug release
reduction of particle size
increase in dispersion
title_short Synthesis of ordered mesoporous silica MCM-41 with controlled morphology for potential application in controlled drug delivery systems
title_full Synthesis of ordered mesoporous silica MCM-41 with controlled morphology for potential application in controlled drug delivery systems
title_fullStr Synthesis of ordered mesoporous silica MCM-41 with controlled morphology for potential application in controlled drug delivery systems
title_full_unstemmed Synthesis of ordered mesoporous silica MCM-41 with controlled morphology for potential application in controlled drug delivery systems
title_sort Synthesis of ordered mesoporous silica MCM-41 with controlled morphology for potential application in controlled drug delivery systems
author Oliveira,D. M.
author_facet Oliveira,D. M.
Andrada,A. S.
author_role author
author2 Andrada,A. S.
author2_role author
dc.contributor.author.fl_str_mv Oliveira,D. M.
Andrada,A. S.
dc.subject.por.fl_str_mv MCM-41
controlled drug release
reduction of particle size
increase in dispersion
topic MCM-41
controlled drug release
reduction of particle size
increase in dispersion
description Abstract MCM-41 is one of the most studied mesoporous ceramics for drug delivery systems. Its high specific surface area and mesoporosity allow high adsorption capacity. Even though there are many studies published in the biomedical field, there are no reports of commercial applications of MCM-41 so far. One of the possible justifications is the lack of morphological control during conventional synthesis. Therefore, modifications in the reaction parameters of the MCM-41 conventional synthesis were tested in this paper, aiming to obtain particles with reduced diameter and agglomeration. It was observed that both the increase in the water molar proportion and the decrease in the stirring time resulted in particles with reduced size. Furthermore, the control of the tetraethyl orthosilicate (TEOS) dropping rate and the addition of triethylamine (TEA) improved the dispersion of the system, but they also decreased the particle size, and therefore van der Waals interactions promoted re-agglomeration.
publishDate 2019
dc.date.none.fl_str_mv 2019-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0366-69132019000200170
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0366-69132019000200170
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0366-69132019653742509
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Cerâmica
publisher.none.fl_str_mv Associação Brasileira de Cerâmica
dc.source.none.fl_str_mv Cerâmica v.65 n.374 2019
reponame:Cerâmica (São Paulo. Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Cerâmica (São Paulo. Online)
collection Cerâmica (São Paulo. Online)
repository.name.fl_str_mv Cerâmica (São Paulo. Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ceram.abc@gmail.com||ceram.abc@gmail.com
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