Validation of a spectrophotometric method to determine ciprofibrate content in tablets

Detalhes bibliográficos
Autor(a) principal: Nascimento, Guilherme Nobre Lima do
Data de Publicação: 2011
Outros Autores: Rosa, Daniel Lerner da, Nishijo, Hisao, Aversi-Ferreira, Tales Alexandre
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/10852
Resumo: Ciprofibrate is a drug indicated in cases of hypertriglyceridemia and mixed hyperlipidemia, but no monographs are available in official compendia for the analysis of this substance in tablets. The objective of this work was to develop and validate a spectrophotometric method for routine analysis of ciprofibrate in tablets. In this study, commercial and standard ciprofibrate were used, as well as placebo in absolute ethanol, analyzed by UV spectrophotometer. All tests followed the rules of Resolution RE-899, 2003. The results showed that the developed and validated method offers low cost, easy implementation, precision and accuracy, and may be included in the routine of quality control laboratories.
id USP-31_7275eada85b7d09cecee49a611f82c4c
oai_identifier_str oai:revistas.usp.br:article/10852
network_acronym_str USP-31
network_name_str Brazilian Journal of Pharmaceutical Sciences
repository_id_str
spelling Validation of a spectrophotometric method to determine ciprofibrate content in tablets Ciprofibrato^i2^sanálMétodo espectrofotométrico^i2^sanálise de medicamenMedicamentos^i2^scontrole de qualidCiprofibrate^i1^sanalySpectrophotometric method^i1^smedicines analyMedicines^i1^squality cont Ciprofibrate is a drug indicated in cases of hypertriglyceridemia and mixed hyperlipidemia, but no monographs are available in official compendia for the analysis of this substance in tablets. The objective of this work was to develop and validate a spectrophotometric method for routine analysis of ciprofibrate in tablets. In this study, commercial and standard ciprofibrate were used, as well as placebo in absolute ethanol, analyzed by UV spectrophotometer. All tests followed the rules of Resolution RE-899, 2003. The results showed that the developed and validated method offers low cost, easy implementation, precision and accuracy, and may be included in the routine of quality control laboratories. O ciprofibrato é um fármaco indicado em casos de hipertrigliceridemia e hiperlipidemia mista, mas não há monografias em compêndios oficiais para a análise desta substância em comprimidos. O objetivo deste trabalho é desenvolver e validar um método espectrofotométrico para análise de rotina de ciprofibrato em comprimidos. Neste estudo foram empregados ciprofibrato comercial, padrão e placebo em etanol absoluto, analisadas por espectrofotometria UV. Todos os testes seguiram as regras da Resolução RE- 899, 2003. Os resultados mostraram que o método desenvolvido e validado apresenta baixo custo, fácil implementação, precisão e exatidão e pode ser incluído em rotina de laboratórios de controle de qualidade. Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2011-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/1085210.1590/S1984-82502011000100004Brazilian Journal of Pharmaceutical Sciences; Vol. 47 No. 1 (2011); 23-29 Brazilian Journal of Pharmaceutical Sciences; v. 47 n. 1 (2011); 23-29 Brazilian Journal of Pharmaceutical Sciences; Vol. 47 Núm. 1 (2011); 23-29 2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/10852/12620Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessNascimento, Guilherme Nobre Lima doRosa, Daniel Lerner daNishijo, HisaoAversi-Ferreira, Tales Alexandre2012-05-12T16:09:31Zoai:revistas.usp.br:article/10852Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2012-05-12T16:09:31Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Validation of a spectrophotometric method to determine ciprofibrate content in tablets
title Validation of a spectrophotometric method to determine ciprofibrate content in tablets
spellingShingle Validation of a spectrophotometric method to determine ciprofibrate content in tablets
Nascimento, Guilherme Nobre Lima do
Ciprofibrato^i2^sanál
Método espectrofotométrico^i2^sanálise de medicamen
Medicamentos^i2^scontrole de qualid
Ciprofibrate^i1^sanaly
Spectrophotometric method^i1^smedicines analy
Medicines^i1^squality cont
title_short Validation of a spectrophotometric method to determine ciprofibrate content in tablets
title_full Validation of a spectrophotometric method to determine ciprofibrate content in tablets
title_fullStr Validation of a spectrophotometric method to determine ciprofibrate content in tablets
title_full_unstemmed Validation of a spectrophotometric method to determine ciprofibrate content in tablets
title_sort Validation of a spectrophotometric method to determine ciprofibrate content in tablets
author Nascimento, Guilherme Nobre Lima do
author_facet Nascimento, Guilherme Nobre Lima do
Rosa, Daniel Lerner da
Nishijo, Hisao
Aversi-Ferreira, Tales Alexandre
author_role author
author2 Rosa, Daniel Lerner da
Nishijo, Hisao
Aversi-Ferreira, Tales Alexandre
author2_role author
author
author
dc.contributor.author.fl_str_mv Nascimento, Guilherme Nobre Lima do
Rosa, Daniel Lerner da
Nishijo, Hisao
Aversi-Ferreira, Tales Alexandre
dc.subject.por.fl_str_mv Ciprofibrato^i2^sanál
Método espectrofotométrico^i2^sanálise de medicamen
Medicamentos^i2^scontrole de qualid
Ciprofibrate^i1^sanaly
Spectrophotometric method^i1^smedicines analy
Medicines^i1^squality cont
topic Ciprofibrato^i2^sanál
Método espectrofotométrico^i2^sanálise de medicamen
Medicamentos^i2^scontrole de qualid
Ciprofibrate^i1^sanaly
Spectrophotometric method^i1^smedicines analy
Medicines^i1^squality cont
description Ciprofibrate is a drug indicated in cases of hypertriglyceridemia and mixed hyperlipidemia, but no monographs are available in official compendia for the analysis of this substance in tablets. The objective of this work was to develop and validate a spectrophotometric method for routine analysis of ciprofibrate in tablets. In this study, commercial and standard ciprofibrate were used, as well as placebo in absolute ethanol, analyzed by UV spectrophotometer. All tests followed the rules of Resolution RE-899, 2003. The results showed that the developed and validated method offers low cost, easy implementation, precision and accuracy, and may be included in the routine of quality control laboratories.
publishDate 2011
dc.date.none.fl_str_mv 2011-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/10852
10.1590/S1984-82502011000100004
url https://www.revistas.usp.br/bjps/article/view/10852
identifier_str_mv 10.1590/S1984-82502011000100004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/10852/12620
dc.rights.driver.fl_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 47 No. 1 (2011); 23-29
Brazilian Journal of Pharmaceutical Sciences; v. 47 n. 1 (2011); 23-29
Brazilian Journal of Pharmaceutical Sciences; Vol. 47 Núm. 1 (2011); 23-29
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
_version_ 1787713367398416384

Registros relacionados