Toxicity assessment of the alcoholic leaves extract of Reinwardtia indica
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/160831 |
Resumo: | The present study aimed to evaluate the safety of the alcoholic leaves extract of Reinwardtia indica in Charles foster rats through an acute and sub-acute oral administration.For assessment of acute oral toxicity test, ratswere orally treated with single dose of the alcoholic leaves extract of Reinwardtia indica at the doses of 50, 250, 500, 1000 2000 and 5000 mg/kg. In sub-acute toxicity study, using the OECD guidelines no. 407, the extract was administered at the doses of 50, 250, 500, 1000, 2000 mg/kg/day for 28 consecutive days and at the dose of 2000 mg/kg satellite group also used for 6 weeks.In acute toxicity above mentioned doses neither showed mortality nor exterior signs of toxicity. In sub-acute, study no significant changes found in haematological and biochemical level ofthe treated rat after 14 days and 28 days in comparison to control. The histopathology of rat brain, kidney, liver, and heart also showed the no cellular changes after extract treated rat.The alcoholic leaves extract of Reinwardtia indica was found non-toxic in single drug dose administration up to 5000 mg/kg (acute study) and in sub-acute administration up to 2000 mg/kg. |
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Brazilian Journal of Pharmaceutical Sciences |
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Toxicity assessment of the alcoholic leaves extract of Reinwardtia indicaReinwardtia indicaBiochemical testHematological testHistopathologyThe present study aimed to evaluate the safety of the alcoholic leaves extract of Reinwardtia indica in Charles foster rats through an acute and sub-acute oral administration.For assessment of acute oral toxicity test, ratswere orally treated with single dose of the alcoholic leaves extract of Reinwardtia indica at the doses of 50, 250, 500, 1000 2000 and 5000 mg/kg. In sub-acute toxicity study, using the OECD guidelines no. 407, the extract was administered at the doses of 50, 250, 500, 1000, 2000 mg/kg/day for 28 consecutive days and at the dose of 2000 mg/kg satellite group also used for 6 weeks.In acute toxicity above mentioned doses neither showed mortality nor exterior signs of toxicity. In sub-acute, study no significant changes found in haematological and biochemical level ofthe treated rat after 14 days and 28 days in comparison to control. The histopathology of rat brain, kidney, liver, and heart also showed the no cellular changes after extract treated rat.The alcoholic leaves extract of Reinwardtia indica was found non-toxic in single drug dose administration up to 5000 mg/kg (acute study) and in sub-acute administration up to 2000 mg/kg.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2019-08-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/16083110.1590/s2175-97902019000118224Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18224Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e18224Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e182242175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/160831/154996Copyright (c) 2019 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessUpadhyay, PrabhatShukla, RashmiTiwari, Kavindra NathDubey, G PMishra, Sunil Kumar2021-01-11T17:42:17Zoai:revistas.usp.br:article/160831Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-01-11T17:42:17Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Toxicity assessment of the alcoholic leaves extract of Reinwardtia indica |
title |
Toxicity assessment of the alcoholic leaves extract of Reinwardtia indica |
spellingShingle |
Toxicity assessment of the alcoholic leaves extract of Reinwardtia indica Upadhyay, Prabhat Reinwardtia indica Biochemical test Hematological test Histopathology |
title_short |
Toxicity assessment of the alcoholic leaves extract of Reinwardtia indica |
title_full |
Toxicity assessment of the alcoholic leaves extract of Reinwardtia indica |
title_fullStr |
Toxicity assessment of the alcoholic leaves extract of Reinwardtia indica |
title_full_unstemmed |
Toxicity assessment of the alcoholic leaves extract of Reinwardtia indica |
title_sort |
Toxicity assessment of the alcoholic leaves extract of Reinwardtia indica |
author |
Upadhyay, Prabhat |
author_facet |
Upadhyay, Prabhat Shukla, Rashmi Tiwari, Kavindra Nath Dubey, G P Mishra, Sunil Kumar |
author_role |
author |
author2 |
Shukla, Rashmi Tiwari, Kavindra Nath Dubey, G P Mishra, Sunil Kumar |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Upadhyay, Prabhat Shukla, Rashmi Tiwari, Kavindra Nath Dubey, G P Mishra, Sunil Kumar |
dc.subject.por.fl_str_mv |
Reinwardtia indica Biochemical test Hematological test Histopathology |
topic |
Reinwardtia indica Biochemical test Hematological test Histopathology |
description |
The present study aimed to evaluate the safety of the alcoholic leaves extract of Reinwardtia indica in Charles foster rats through an acute and sub-acute oral administration.For assessment of acute oral toxicity test, ratswere orally treated with single dose of the alcoholic leaves extract of Reinwardtia indica at the doses of 50, 250, 500, 1000 2000 and 5000 mg/kg. In sub-acute toxicity study, using the OECD guidelines no. 407, the extract was administered at the doses of 50, 250, 500, 1000, 2000 mg/kg/day for 28 consecutive days and at the dose of 2000 mg/kg satellite group also used for 6 weeks.In acute toxicity above mentioned doses neither showed mortality nor exterior signs of toxicity. In sub-acute, study no significant changes found in haematological and biochemical level ofthe treated rat after 14 days and 28 days in comparison to control. The histopathology of rat brain, kidney, liver, and heart also showed the no cellular changes after extract treated rat.The alcoholic leaves extract of Reinwardtia indica was found non-toxic in single drug dose administration up to 5000 mg/kg (acute study) and in sub-acute administration up to 2000 mg/kg. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08-08 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/160831 10.1590/s2175-97902019000118224 |
url |
https://www.revistas.usp.br/bjps/article/view/160831 |
identifier_str_mv |
10.1590/s2175-97902019000118224 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/160831/154996 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18224 Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e18224 Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18224 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222914432204800 |