Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms

Detalhes bibliográficos
Autor(a) principal: Pezzini, Bianca Ramos
Data de Publicação: 2015
Outros Autores: Issa, Michele Georges, Duque, Marcelo Dutra, Ferraz, Humberto Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/102387
Resumo: USP Apparatus 3 (reciprocating cylinder) is a very versatile device for the;in vitro; assessment of release characteristics of solid oral dosage forms, because it enables the product to be subjected to different dissolution media and agitation speeds in a single run. In this paper, a brief history and a description of this system are presented, along with its applications in the development of immediate and modified release products and in the simulation of fasted and fed states using biorelevant media. Furthermore, a comparison is made with the basket and paddle apparatus, especially highlighting the superior hydrodynamics of USP apparatus 3, since the results are not sensitive to factors such as the presence of sample collection probes or air bubbles in the dissolution medium.
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spelling Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage formsUSP Apparatus 3 (reciprocating cylinder) is a very versatile device for the;in vitro; assessment of release characteristics of solid oral dosage forms, because it enables the product to be subjected to different dissolution media and agitation speeds in a single run. In this paper, a brief history and a description of this system are presented, along with its applications in the development of immediate and modified release products and in the simulation of fasted and fed states using biorelevant media. Furthermore, a comparison is made with the basket and paddle apparatus, especially highlighting the superior hydrodynamics of USP apparatus 3, since the results are not sensitive to factors such as the presence of sample collection probes or air bubbles in the dissolution medium.;USP aparato 3 (cilindros recíprocos) é um equipamento bastante versátil para a avaliação das características de liberação ;in vitro; de formas farmacêuticas sólidas orais, pois permite que o produto seja submetido a diferentes meios de dissolução e condições de agitação, em um único ensaio. Neste trabalho, são apresentados um breve histórico e a descrição desse sistema, suas aplicações no desenvolvimento de produtos de liberação imediata e modificada, assim como sua utilização na simulação dos estados não alimentado e alimentado com o emprego de meios biorrelevantes. Além disso, uma comparação é estabelecida com o cesto e a pá, com destaque para a hidrodinâmica superior do USP aparato 3, que faz com que os resultados não sejam influenciados por fatores como o uso de sondas de coleta de amostras ou presença de bolhas de ar no meio de dissolução.;Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/10238710.1590/S1984-82502015000200003Brazilian Journal of Pharmaceutical Sciences; Vol. 51 No. 2 (2015); 265-272Brazilian Journal of Pharmaceutical Sciences; v. 51 n. 2 (2015); 265-272Brazilian Journal of Pharmaceutical Sciences; Vol. 51 Núm. 2 (2015); 265-2722175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/102387/100710Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessPezzini, Bianca RamosIssa, Michele GeorgesDuque, Marcelo DutraFerraz, Humberto Gomes2015-08-18T11:40:13Zoai:revistas.usp.br:article/102387Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2015-08-18T11:40:13Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms
title Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms
spellingShingle Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms
Pezzini, Bianca Ramos
title_short Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms
title_full Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms
title_fullStr Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms
title_full_unstemmed Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms
title_sort Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms
author Pezzini, Bianca Ramos
author_facet Pezzini, Bianca Ramos
Issa, Michele Georges
Duque, Marcelo Dutra
Ferraz, Humberto Gomes
author_role author
author2 Issa, Michele Georges
Duque, Marcelo Dutra
Ferraz, Humberto Gomes
author2_role author
author
author
dc.contributor.author.fl_str_mv Pezzini, Bianca Ramos
Issa, Michele Georges
Duque, Marcelo Dutra
Ferraz, Humberto Gomes
description USP Apparatus 3 (reciprocating cylinder) is a very versatile device for the;in vitro; assessment of release characteristics of solid oral dosage forms, because it enables the product to be subjected to different dissolution media and agitation speeds in a single run. In this paper, a brief history and a description of this system are presented, along with its applications in the development of immediate and modified release products and in the simulation of fasted and fed states using biorelevant media. Furthermore, a comparison is made with the basket and paddle apparatus, especially highlighting the superior hydrodynamics of USP apparatus 3, since the results are not sensitive to factors such as the presence of sample collection probes or air bubbles in the dissolution medium.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/102387
10.1590/S1984-82502015000200003
url https://www.revistas.usp.br/bjps/article/view/102387
identifier_str_mv 10.1590/S1984-82502015000200003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/102387/100710
dc.rights.driver.fl_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 51 No. 2 (2015); 265-272
Brazilian Journal of Pharmaceutical Sciences; v. 51 n. 2 (2015); 265-272
Brazilian Journal of Pharmaceutical Sciences; Vol. 51 Núm. 2 (2015); 265-272
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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