Evaluation of caspase-3 and Ki-67 as a prognostic markers in canine mammary tumors

Detalhes bibliográficos
Autor(a) principal: Terzian, Ana Carolina Bernardes
Data de Publicação: 2007
Outros Autores: Zuccari, Debora Aparecida Pires de Campos, Pereira, Rodrigo Storti, Pavam, Marcília Viana, Ruiz, Camila Montanari, Sueiro, Felipe Augusto Ruiz, Coelho, Joanna
Tipo de documento: Artigo
Idioma: por
Título da fonte: Brazilian Journal of Veterinary Research and Animal Science
Texto Completo: https://www.revistas.usp.br/bjvras/article/view/26647
Resumo: Apoptosis, as a cellular event, has an important participation in tumorigenesis, determining the tumoral growth and aggressiveness. The present study had as objective to evaluate the occurrence of apoptosis, associated cellular proliferation, in canine mammary neoplasias and the patient clinical evolution. Seventy dogs had been submitted to surgical excision of the tumor fragment and they were submitted to the histopathologic diagnosis and imunohistochemistry procedure to caspase-3 and the Ki-67. This apoptosis and cellular proliferation markers demonstrated great expression in malignant neoplasias especially carcinoma, considered the most malignant of the tumors. These results confirm consulted literature contributing for a criterious tumoral prognostic complementing the tumoral classification, providing a greater and better supervened due to adequacy of therapeutic procedure of each patient.
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spelling Evaluation of caspase-3 and Ki-67 as a prognostic markers in canine mammary tumorsAvaliação da caspase-3 e Ki-67 como marcadores prognósticos nas neoplasias mamárias em cadelasNeoplasia mamáriaCadelaImuno-histoquímicaApoptoseProliferação celularMammary tumorsBitchImmunohistochemicalApoptosisCellular proliferationApoptosis, as a cellular event, has an important participation in tumorigenesis, determining the tumoral growth and aggressiveness. The present study had as objective to evaluate the occurrence of apoptosis, associated cellular proliferation, in canine mammary neoplasias and the patient clinical evolution. Seventy dogs had been submitted to surgical excision of the tumor fragment and they were submitted to the histopathologic diagnosis and imunohistochemistry procedure to caspase-3 and the Ki-67. This apoptosis and cellular proliferation markers demonstrated great expression in malignant neoplasias especially carcinoma, considered the most malignant of the tumors. These results confirm consulted literature contributing for a criterious tumoral prognostic complementing the tumoral classification, providing a greater and better supervened due to adequacy of therapeutic procedure of each patient.A apoptose e a proliferação celular possuem uma participação importante na tumorigênese, determinando o crescimento tumoral e consequentemente sua agressividade. O presente estudo teve como objetivo avaliar a ocorrência da apoptose associada a proliferação celular em neoplasias mamárias em cadelas e a elas a evolução clínica do paciente. Setenta animais foram submetidos à exérese cirúrgica do tumor, sendo este submetido ao diagnóstico histopatológico e marcação imuno-histoquímica para caspase-3 e Ki-67. Estes marcadores de apoptose e proliferação celular demonstraram grande expressão nas neoplasias malignas, principalmente nos carcinomas, considerado o mais maligno dos tumores. Estes resultados corroboram os dados da literatura e contribuem para um prognóstico tumoral criterioso que complementa a classificação tumoral existente proporcionando uma melhor e maior sobrevida devido a uma adequação do procedimento terapêutico de cada paciente.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia2007-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/2664710.11606/issn.1678-4456.bjvras.2007.26647Brazilian Journal of Veterinary Research and Animal Science; Vol. 44 Núm. 2 (2007); 96-102Brazilian Journal of Veterinary Research and Animal Science; Vol. 44 No. 2 (2007); 96-102Brazilian Journal of Veterinary Research and Animal Science; v. 44 n. 2 (2007); 96-102Brazilian Journal of Veterinary Research and Animal Science; V. 44 N. 2 (2007); 96-1021678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPporhttps://www.revistas.usp.br/bjvras/article/view/26647/28430Terzian, Ana Carolina BernardesZuccari, Debora Aparecida Pires de CamposPereira, Rodrigo StortiPavam, Marcília VianaRuiz, Camila MontanariSueiro, Felipe Augusto RuizCoelho, Joannainfo:eu-repo/semantics/openAccess2020-06-23T04:15:28Zoai:revistas.usp.br:article/26647Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:42:55.669263Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false
dc.title.none.fl_str_mv Evaluation of caspase-3 and Ki-67 as a prognostic markers in canine mammary tumors
Avaliação da caspase-3 e Ki-67 como marcadores prognósticos nas neoplasias mamárias em cadelas
title Evaluation of caspase-3 and Ki-67 as a prognostic markers in canine mammary tumors
spellingShingle Evaluation of caspase-3 and Ki-67 as a prognostic markers in canine mammary tumors
Terzian, Ana Carolina Bernardes
Neoplasia mamária
Cadela
Imuno-histoquímica
Apoptose
Proliferação celular
Mammary tumors
Bitch
Immunohistochemical
Apoptosis
Cellular proliferation
title_short Evaluation of caspase-3 and Ki-67 as a prognostic markers in canine mammary tumors
title_full Evaluation of caspase-3 and Ki-67 as a prognostic markers in canine mammary tumors
title_fullStr Evaluation of caspase-3 and Ki-67 as a prognostic markers in canine mammary tumors
title_full_unstemmed Evaluation of caspase-3 and Ki-67 as a prognostic markers in canine mammary tumors
title_sort Evaluation of caspase-3 and Ki-67 as a prognostic markers in canine mammary tumors
author Terzian, Ana Carolina Bernardes
author_facet Terzian, Ana Carolina Bernardes
Zuccari, Debora Aparecida Pires de Campos
Pereira, Rodrigo Storti
Pavam, Marcília Viana
Ruiz, Camila Montanari
Sueiro, Felipe Augusto Ruiz
Coelho, Joanna
author_role author
author2 Zuccari, Debora Aparecida Pires de Campos
Pereira, Rodrigo Storti
Pavam, Marcília Viana
Ruiz, Camila Montanari
Sueiro, Felipe Augusto Ruiz
Coelho, Joanna
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Terzian, Ana Carolina Bernardes
Zuccari, Debora Aparecida Pires de Campos
Pereira, Rodrigo Storti
Pavam, Marcília Viana
Ruiz, Camila Montanari
Sueiro, Felipe Augusto Ruiz
Coelho, Joanna
dc.subject.por.fl_str_mv Neoplasia mamária
Cadela
Imuno-histoquímica
Apoptose
Proliferação celular
Mammary tumors
Bitch
Immunohistochemical
Apoptosis
Cellular proliferation
topic Neoplasia mamária
Cadela
Imuno-histoquímica
Apoptose
Proliferação celular
Mammary tumors
Bitch
Immunohistochemical
Apoptosis
Cellular proliferation
description Apoptosis, as a cellular event, has an important participation in tumorigenesis, determining the tumoral growth and aggressiveness. The present study had as objective to evaluate the occurrence of apoptosis, associated cellular proliferation, in canine mammary neoplasias and the patient clinical evolution. Seventy dogs had been submitted to surgical excision of the tumor fragment and they were submitted to the histopathologic diagnosis and imunohistochemistry procedure to caspase-3 and the Ki-67. This apoptosis and cellular proliferation markers demonstrated great expression in malignant neoplasias especially carcinoma, considered the most malignant of the tumors. These results confirm consulted literature contributing for a criterious tumoral prognostic complementing the tumoral classification, providing a greater and better supervened due to adequacy of therapeutic procedure of each patient.
publishDate 2007
dc.date.none.fl_str_mv 2007-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjvras/article/view/26647
10.11606/issn.1678-4456.bjvras.2007.26647
url https://www.revistas.usp.br/bjvras/article/view/26647
identifier_str_mv 10.11606/issn.1678-4456.bjvras.2007.26647
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjvras/article/view/26647/28430
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
dc.source.none.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science; Vol. 44 Núm. 2 (2007); 96-102
Brazilian Journal of Veterinary Research and Animal Science; Vol. 44 No. 2 (2007); 96-102
Brazilian Journal of Veterinary Research and Animal Science; v. 44 n. 2 (2007); 96-102
Brazilian Journal of Veterinary Research and Animal Science; V. 44 N. 2 (2007); 96-102
1678-4456
1413-9596
reponame:Brazilian Journal of Veterinary Research and Animal Science
instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
instacron:USP
instname_str Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Veterinary Research and Animal Science
collection Brazilian Journal of Veterinary Research and Animal Science
repository.name.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
repository.mail.fl_str_mv bjvras@usp.br
_version_ 1797051558714671104

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