The Central Nervous System stimulant effects of the ethanolic extract from the toxic brazilian plant Pseudocalymma elegam
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Veterinary Research and Animal Science |
Texto Completo: | https://www.revistas.usp.br/bjvras/article/view/50163 |
Resumo: | The effects of the ethanolic extract from the Brazilian toxic plant Pseudocalymma elegans (Veil.) Kuhlm. upon the behavior of mice were studied. Mice that received 1.6 to 3 g/kg of body weight extract presented seizure-like signs dying with a mean latency of 8 min. The LD50 in this situation was estimated in 1.8 g/kg. Mice that received extract 1 g/kg i.p. were observed in an open field 30 min later, presented a decrease in the number of rearings and an increase in the freezing time, without significant differences in the number of crossings, grooming time or number of fecal boluses compared to the control group. Mice submitted to the same treatment and tested on the elevated plus-maze presented a reduction in the percentage of entries and in the time spent in the open arms of the maze. These animals reduced the locomotor activity measured automatically and presented no difference in the muscular tonus, measured by the time of permanence hanging from a wire. These data suggest that the plant extract has compounds with stimulant effects upon the central nervous system: In a lower dose (1 g/kg) we observed behavioral effects that suggest an anxiogenic action of the extract without affecting the muscular tonus, and higher doses resulted in convulsions and death. |
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Brazilian Journal of Veterinary Research and Animal Science |
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The Central Nervous System stimulant effects of the ethanolic extract from the toxic brazilian plant Pseudocalymma elegamO extrato etanólico da planta tóxicca brasileira, Psedocalymma elegans apresenta efeitos estimulantes sobre o Sistema Nervoso CentralPseudocalymma elegansPlantas venenosasConvulsõesSistema nervoso centralCamundongos.Pseudocalymma elegansPoisonous plantsConvulsionsCentral nervous systemMice.The effects of the ethanolic extract from the Brazilian toxic plant Pseudocalymma elegans (Veil.) Kuhlm. upon the behavior of mice were studied. Mice that received 1.6 to 3 g/kg of body weight extract presented seizure-like signs dying with a mean latency of 8 min. The LD50 in this situation was estimated in 1.8 g/kg. Mice that received extract 1 g/kg i.p. were observed in an open field 30 min later, presented a decrease in the number of rearings and an increase in the freezing time, without significant differences in the number of crossings, grooming time or number of fecal boluses compared to the control group. Mice submitted to the same treatment and tested on the elevated plus-maze presented a reduction in the percentage of entries and in the time spent in the open arms of the maze. These animals reduced the locomotor activity measured automatically and presented no difference in the muscular tonus, measured by the time of permanence hanging from a wire. These data suggest that the plant extract has compounds with stimulant effects upon the central nervous system: In a lower dose (1 g/kg) we observed behavioral effects that suggest an anxiogenic action of the extract without affecting the muscular tonus, and higher doses resulted in convulsions and death.Os efeitos do extrato etanólico da planta tóxica Pseudocalymma elegans (Vell.) Kuhlm. sobre o comportamento de camundongos foi estudado. Camundongos que receberam injeções intraperitoneais (i.p.), nas doses de 1.6 a 3 g/kg de peso corporal, apresentaram convulsões e morreram com uma latência média de 8 min. A LD50 foi estimada em 1.8 g/kg. Os camundongos que receberam 1 g/kg (i.p.) do extrato apresentaram um maior número de “rearings” e um maior tempo de “freezing” do que o grupo controle, quando observados em um campo aberto 30 min após a injeção. Durante o tempo em que esses animais foram observados no campo aberto não ocorreram alterações significativas no número de cruzamentos, tempo de “grooming” e número de bolos fecais. Quando esses animais foram colocados em um labirinto em cruz elevado exploraram menos os braços abertos do labirinto que os animais controle; apresentaram uma menor porcentagem de entradas e uma menor porcentagem de tempo de permanência nos braços abertos do labirinto. Esses animais apresentaram também uma menor atividade locomotora medida de forma automatizada e nenhuma alteração no tônus muscular, avaliado pelo tempo de permanência em um arame esticado. Os três primeiros testes sugerem que a administração de doses moderadas do extrato desencadeia um efeito “ansiogênico” contrário ao observado com a administração de ansiolíticos depressores do sistema nervoso central (SNC). Doses maiores do extrato provocam uma super-estimulação do SNC com convulsões que, eventualmente, podem contribuir paraa letalidade do extrato.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia1996-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/5016310.11606/issn.2318-3659.v33i2p82-88Brazilian Journal of Veterinary Research and Animal Science; Vol. 33 Núm. 2 (1996); 82-88Brazilian Journal of Veterinary Research and Animal Science; Vol. 33 No. 2 (1996); 82-88Brazilian Journal of Veterinary Research and Animal Science; v. 33 n. 2 (1996); 82-88Brazilian Journal of Veterinary Research and Animal Science; V. 33 N. 2 (1996); 82-881678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPenghttps://www.revistas.usp.br/bjvras/article/view/50163/54278Schütz, Romeu AfonsoSchütz, Maria Teresa BarrosAngelucci, Miriam Elizabeth MendesCunha, Cláudio dainfo:eu-repo/semantics/openAccess2020-06-23T04:50:10Zoai:revistas.usp.br:article/50163Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:43:14.492766Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false |
dc.title.none.fl_str_mv |
The Central Nervous System stimulant effects of the ethanolic extract from the toxic brazilian plant Pseudocalymma elegam O extrato etanólico da planta tóxicca brasileira, Psedocalymma elegans apresenta efeitos estimulantes sobre o Sistema Nervoso Central |
title |
The Central Nervous System stimulant effects of the ethanolic extract from the toxic brazilian plant Pseudocalymma elegam |
spellingShingle |
The Central Nervous System stimulant effects of the ethanolic extract from the toxic brazilian plant Pseudocalymma elegam Schütz, Romeu Afonso Pseudocalymma elegans Plantas venenosas Convulsões Sistema nervoso central Camundongos. Pseudocalymma elegans Poisonous plants Convulsions Central nervous system Mice. |
title_short |
The Central Nervous System stimulant effects of the ethanolic extract from the toxic brazilian plant Pseudocalymma elegam |
title_full |
The Central Nervous System stimulant effects of the ethanolic extract from the toxic brazilian plant Pseudocalymma elegam |
title_fullStr |
The Central Nervous System stimulant effects of the ethanolic extract from the toxic brazilian plant Pseudocalymma elegam |
title_full_unstemmed |
The Central Nervous System stimulant effects of the ethanolic extract from the toxic brazilian plant Pseudocalymma elegam |
title_sort |
The Central Nervous System stimulant effects of the ethanolic extract from the toxic brazilian plant Pseudocalymma elegam |
author |
Schütz, Romeu Afonso |
author_facet |
Schütz, Romeu Afonso Schütz, Maria Teresa Barros Angelucci, Miriam Elizabeth Mendes Cunha, Cláudio da |
author_role |
author |
author2 |
Schütz, Maria Teresa Barros Angelucci, Miriam Elizabeth Mendes Cunha, Cláudio da |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Schütz, Romeu Afonso Schütz, Maria Teresa Barros Angelucci, Miriam Elizabeth Mendes Cunha, Cláudio da |
dc.subject.por.fl_str_mv |
Pseudocalymma elegans Plantas venenosas Convulsões Sistema nervoso central Camundongos. Pseudocalymma elegans Poisonous plants Convulsions Central nervous system Mice. |
topic |
Pseudocalymma elegans Plantas venenosas Convulsões Sistema nervoso central Camundongos. Pseudocalymma elegans Poisonous plants Convulsions Central nervous system Mice. |
description |
The effects of the ethanolic extract from the Brazilian toxic plant Pseudocalymma elegans (Veil.) Kuhlm. upon the behavior of mice were studied. Mice that received 1.6 to 3 g/kg of body weight extract presented seizure-like signs dying with a mean latency of 8 min. The LD50 in this situation was estimated in 1.8 g/kg. Mice that received extract 1 g/kg i.p. were observed in an open field 30 min later, presented a decrease in the number of rearings and an increase in the freezing time, without significant differences in the number of crossings, grooming time or number of fecal boluses compared to the control group. Mice submitted to the same treatment and tested on the elevated plus-maze presented a reduction in the percentage of entries and in the time spent in the open arms of the maze. These animals reduced the locomotor activity measured automatically and presented no difference in the muscular tonus, measured by the time of permanence hanging from a wire. These data suggest that the plant extract has compounds with stimulant effects upon the central nervous system: In a lower dose (1 g/kg) we observed behavioral effects that suggest an anxiogenic action of the extract without affecting the muscular tonus, and higher doses resulted in convulsions and death. |
publishDate |
1996 |
dc.date.none.fl_str_mv |
1996-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/50163 10.11606/issn.2318-3659.v33i2p82-88 |
url |
https://www.revistas.usp.br/bjvras/article/view/50163 |
identifier_str_mv |
10.11606/issn.2318-3659.v33i2p82-88 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/50163/54278 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science; Vol. 33 Núm. 2 (1996); 82-88 Brazilian Journal of Veterinary Research and Animal Science; Vol. 33 No. 2 (1996); 82-88 Brazilian Journal of Veterinary Research and Animal Science; v. 33 n. 2 (1996); 82-88 Brazilian Journal of Veterinary Research and Animal Science; V. 33 N. 2 (1996); 82-88 1678-4456 1413-9596 reponame:Brazilian Journal of Veterinary Research and Animal Science instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) instacron:USP |
instname_str |
Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Veterinary Research and Animal Science |
collection |
Brazilian Journal of Veterinary Research and Animal Science |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
repository.mail.fl_str_mv |
bjvras@usp.br |
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1797051562550362112 |