Alguns eventos morfológicos do processo de reparo de falha óssea diafisária no rádio esquerdo de ratos tratados com fenobarbital
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Veterinary Research and Animal Science |
Texto Completo: | https://www.revistas.usp.br/bjvras/article/view/5745 |
Resumo: | The aim of this report was to investigate in the albino rat the morphological effects of prolonged treatment with phenobarbital on the repair of induced diaphysary bone failure of the left radius. Forty-day-old experimental male rats (Rattus norvegicus albinus) were treated daily with subcutaneous dose of 105 mg/kg weight of phenobarbital (Gardenal, Rhodia®), for 50, 70 and 90 days of treatment. A control group was treated daily with 0.9% NaCl isotonic solution for the same periods, similar to the experimental rats. On the 30th day of treatments a 2 mm diaphysary bone failure was surgically made in the left radius of the rats of the both groups. The left radius was collected post-mortem on 20th, 40th and 60th days after the surgeries and was processed histologically for light microscope studies, with emphasis to morphometric analyses. The diaphysary bone failures of experimental rats showed a lesser volumetric range of renewed osseus tissue, when compared to the osseous tissue regeneration presented in diaphysary bone failures of control rats. The results allowed to conclude that phenobarbital prolonged treatment inhibits the osteogenesis in long bones, retarding the process of diaphysary bone failure repair in rat. |
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Brazilian Journal of Veterinary Research and Animal Science |
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Alguns eventos morfológicos do processo de reparo de falha óssea diafisária no rádio esquerdo de ratos tratados com fenobarbitalSome morphological events of the healing of diaphisary bone failure in the left radius of rats under phenobarbital treatmentMorfologiaOssosFenobarbitalRatosMorphologyBonesPhenobarbitalRatsThe aim of this report was to investigate in the albino rat the morphological effects of prolonged treatment with phenobarbital on the repair of induced diaphysary bone failure of the left radius. Forty-day-old experimental male rats (Rattus norvegicus albinus) were treated daily with subcutaneous dose of 105 mg/kg weight of phenobarbital (Gardenal, Rhodia®), for 50, 70 and 90 days of treatment. A control group was treated daily with 0.9% NaCl isotonic solution for the same periods, similar to the experimental rats. On the 30th day of treatments a 2 mm diaphysary bone failure was surgically made in the left radius of the rats of the both groups. The left radius was collected post-mortem on 20th, 40th and 60th days after the surgeries and was processed histologically for light microscope studies, with emphasis to morphometric analyses. The diaphysary bone failures of experimental rats showed a lesser volumetric range of renewed osseus tissue, when compared to the osseous tissue regeneration presented in diaphysary bone failures of control rats. The results allowed to conclude that phenobarbital prolonged treatment inhibits the osteogenesis in long bones, retarding the process of diaphysary bone failure repair in rat.O objetivo deste trabalho foi investigar os efeitos morfológicos do tratamento prolongado com fenobarbital, na consolidação de falha óssea diafisária, induzida no rádio esquerdo de rato. Ratos machos albinos da linhagem Wistar, com 40 dias de idade, foram divididos em dois grupos. O grupo experimental foi tratado com fenobarbital (Gardenal®) na dose de 105 mg/kg de peso corpóreo, por via subcutânea, no período de até 90 dias. O grupo controle foi tratado, de modo similar, com solução de NaCl 0,9%. No 30º dia de tratamento, os animais foram submetidos a cirurgia para produção de falha óssea diafisária de 2 mm, no rádio esquerdo. Após 20, 40 e 60 dias de cirurgia, os ratos foram sacrificados por inalação de éter etílico, e o rádio esquerdo foi coletado, fixado e processado para rotina histológica de microscopia óptica com análises morfométricas. As falhas ósseas diafisárias dos ratos experimentais mostravam menor fração de volume de tecido ósseo neoformado, comparativamente com as falhas ósseas diafisárias dos ratos controle. Os resultados observados foram indicativos de que o tratamento prolongado com fenobarbital inibe a osteogênese em osso longo, retardando o processo de reparo de falha óssea diafisária em rato.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia1999-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/574510.1590/S1413-95961999000400004Brazilian Journal of Veterinary Research and Animal Science; Vol. 36 Núm. 4 (1999); 188-193Brazilian Journal of Veterinary Research and Animal Science; Vol. 36 No. 4 (1999); 188-193Brazilian Journal of Veterinary Research and Animal Science; v. 36 n. 4 (1999); 188-193Brazilian Journal of Veterinary Research and Animal Science; V. 36 N. 4 (1999); 188-1931678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPporhttps://www.revistas.usp.br/bjvras/article/view/5745/64788Mascarenhas, Nilva Maria FreresIderiha, Nilce MarzollaOrsi, Antonio Marcosinfo:eu-repo/semantics/openAccess2020-06-23T04:44:01Zoai:revistas.usp.br:article/5745Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:42:20.278128Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false |
dc.title.none.fl_str_mv |
Alguns eventos morfológicos do processo de reparo de falha óssea diafisária no rádio esquerdo de ratos tratados com fenobarbital Some morphological events of the healing of diaphisary bone failure in the left radius of rats under phenobarbital treatment |
title |
Alguns eventos morfológicos do processo de reparo de falha óssea diafisária no rádio esquerdo de ratos tratados com fenobarbital |
spellingShingle |
Alguns eventos morfológicos do processo de reparo de falha óssea diafisária no rádio esquerdo de ratos tratados com fenobarbital Mascarenhas, Nilva Maria Freres Morfologia Ossos Fenobarbital Ratos Morphology Bones Phenobarbital Rats |
title_short |
Alguns eventos morfológicos do processo de reparo de falha óssea diafisária no rádio esquerdo de ratos tratados com fenobarbital |
title_full |
Alguns eventos morfológicos do processo de reparo de falha óssea diafisária no rádio esquerdo de ratos tratados com fenobarbital |
title_fullStr |
Alguns eventos morfológicos do processo de reparo de falha óssea diafisária no rádio esquerdo de ratos tratados com fenobarbital |
title_full_unstemmed |
Alguns eventos morfológicos do processo de reparo de falha óssea diafisária no rádio esquerdo de ratos tratados com fenobarbital |
title_sort |
Alguns eventos morfológicos do processo de reparo de falha óssea diafisária no rádio esquerdo de ratos tratados com fenobarbital |
author |
Mascarenhas, Nilva Maria Freres |
author_facet |
Mascarenhas, Nilva Maria Freres Ideriha, Nilce Marzolla Orsi, Antonio Marcos |
author_role |
author |
author2 |
Ideriha, Nilce Marzolla Orsi, Antonio Marcos |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Mascarenhas, Nilva Maria Freres Ideriha, Nilce Marzolla Orsi, Antonio Marcos |
dc.subject.por.fl_str_mv |
Morfologia Ossos Fenobarbital Ratos Morphology Bones Phenobarbital Rats |
topic |
Morfologia Ossos Fenobarbital Ratos Morphology Bones Phenobarbital Rats |
description |
The aim of this report was to investigate in the albino rat the morphological effects of prolonged treatment with phenobarbital on the repair of induced diaphysary bone failure of the left radius. Forty-day-old experimental male rats (Rattus norvegicus albinus) were treated daily with subcutaneous dose of 105 mg/kg weight of phenobarbital (Gardenal, Rhodia®), for 50, 70 and 90 days of treatment. A control group was treated daily with 0.9% NaCl isotonic solution for the same periods, similar to the experimental rats. On the 30th day of treatments a 2 mm diaphysary bone failure was surgically made in the left radius of the rats of the both groups. The left radius was collected post-mortem on 20th, 40th and 60th days after the surgeries and was processed histologically for light microscope studies, with emphasis to morphometric analyses. The diaphysary bone failures of experimental rats showed a lesser volumetric range of renewed osseus tissue, when compared to the osseous tissue regeneration presented in diaphysary bone failures of control rats. The results allowed to conclude that phenobarbital prolonged treatment inhibits the osteogenesis in long bones, retarding the process of diaphysary bone failure repair in rat. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/5745 10.1590/S1413-95961999000400004 |
url |
https://www.revistas.usp.br/bjvras/article/view/5745 |
identifier_str_mv |
10.1590/S1413-95961999000400004 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/5745/64788 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science; Vol. 36 Núm. 4 (1999); 188-193 Brazilian Journal of Veterinary Research and Animal Science; Vol. 36 No. 4 (1999); 188-193 Brazilian Journal of Veterinary Research and Animal Science; v. 36 n. 4 (1999); 188-193 Brazilian Journal of Veterinary Research and Animal Science; V. 36 N. 4 (1999); 188-193 1678-4456 1413-9596 reponame:Brazilian Journal of Veterinary Research and Animal Science instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) instacron:USP |
instname_str |
Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Veterinary Research and Animal Science |
collection |
Brazilian Journal of Veterinary Research and Animal Science |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
repository.mail.fl_str_mv |
bjvras@usp.br |
_version_ |
1797051554681847808 |