Bowel preparation for colonoscopy: comparison of mannitol and sodium phosphate. Results of a prospective randomized study
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Hospital das Clínicas |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87811999000600004 |
Resumo: | METHOD: Eighty patients were prospectively randomized for precolonoscopic cleansing either with 750 ml of 10% mannitol (Group M) or 180 ml of a sodium phosphate preparation (Group NaP). Laboratory examinations before and after preparation on all patients included hemoglobin, hematocrit, sodium, potassium, phosphorous, calcium and serum osmolarity. A questionnaire was used to assess undesirable side effects and patient tolerance to the solution. The quality of preparation was assessed by the endoscopist who was unaware of the solution employed. RESULTS: Statistically significant changes were verified in serum sodium, phosphorous, potassium and calcium between the two groups, but no clinical symptoms were observed. There were no significant differences in the frequency of side effects studied. Six of the eight patients in Group NaP who had taken mannitol for a previous colonoscopy claimed better acceptance of the sodium phosphate solution. The endoscopic-blinded trial reported excellent or good bowel preparation in 85% prepared with sodium phosphate versus 82.5% for mannitol (p=0.37). CONCLUSIONS: Quality of preparation and frequency of side effects was similar in the two solutions. The smaller volume of sodium phosphate necessary for preparation seems to be related to its favorable acceptance. Nevertheless, the retention of sodium and phosphate ions contraindicates the use of sodium phosphate in patients with renal failure, cirrhosis, ascites, and heart failure. |
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Bowel preparation for colonoscopy: comparison of mannitol and sodium phosphate. Results of a prospective randomized studyBowel preparationColonoscopyOral solution of sodium phosphateMETHOD: Eighty patients were prospectively randomized for precolonoscopic cleansing either with 750 ml of 10% mannitol (Group M) or 180 ml of a sodium phosphate preparation (Group NaP). Laboratory examinations before and after preparation on all patients included hemoglobin, hematocrit, sodium, potassium, phosphorous, calcium and serum osmolarity. A questionnaire was used to assess undesirable side effects and patient tolerance to the solution. The quality of preparation was assessed by the endoscopist who was unaware of the solution employed. RESULTS: Statistically significant changes were verified in serum sodium, phosphorous, potassium and calcium between the two groups, but no clinical symptoms were observed. There were no significant differences in the frequency of side effects studied. Six of the eight patients in Group NaP who had taken mannitol for a previous colonoscopy claimed better acceptance of the sodium phosphate solution. The endoscopic-blinded trial reported excellent or good bowel preparation in 85% prepared with sodium phosphate versus 82.5% for mannitol (p=0.37). CONCLUSIONS: Quality of preparation and frequency of side effects was similar in the two solutions. The smaller volume of sodium phosphate necessary for preparation seems to be related to its favorable acceptance. Nevertheless, the retention of sodium and phosphate ions contraindicates the use of sodium phosphate in patients with renal failure, cirrhosis, ascites, and heart failure.Faculdade de Medicina / Universidade de São Paulo - FM/USP1999-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87811999000600004Revista do Hospital das Clínicas v.54 n.6 1999reponame:Revista do Hospital das Clínicasinstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0041-87811999000600004info:eu-repo/semantics/openAccessHabr-Gama,AngelitaBringel,Robert William de AzevedoNahas,Sergio CarlosAraújo,Sergio Eduardo de AlonsoSouza Junior,Afonso Henrique deCalache,João EliasAlves,Paulo Arrudaeng2000-07-20T00:00:00Zoai:scielo:S0041-87811999000600004Revistahttp://www.scielo.br/rhcPUBhttps://old.scielo.br/oai/scielo-oai.php||revista.hc@hcnet.usp.br1678-99030041-8781opendoar:2000-07-20T00:00Revista do Hospital das Clínicas - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Bowel preparation for colonoscopy: comparison of mannitol and sodium phosphate. Results of a prospective randomized study |
title |
Bowel preparation for colonoscopy: comparison of mannitol and sodium phosphate. Results of a prospective randomized study |
spellingShingle |
Bowel preparation for colonoscopy: comparison of mannitol and sodium phosphate. Results of a prospective randomized study Habr-Gama,Angelita Bowel preparation Colonoscopy Oral solution of sodium phosphate |
title_short |
Bowel preparation for colonoscopy: comparison of mannitol and sodium phosphate. Results of a prospective randomized study |
title_full |
Bowel preparation for colonoscopy: comparison of mannitol and sodium phosphate. Results of a prospective randomized study |
title_fullStr |
Bowel preparation for colonoscopy: comparison of mannitol and sodium phosphate. Results of a prospective randomized study |
title_full_unstemmed |
Bowel preparation for colonoscopy: comparison of mannitol and sodium phosphate. Results of a prospective randomized study |
title_sort |
Bowel preparation for colonoscopy: comparison of mannitol and sodium phosphate. Results of a prospective randomized study |
author |
Habr-Gama,Angelita |
author_facet |
Habr-Gama,Angelita Bringel,Robert William de Azevedo Nahas,Sergio Carlos Araújo,Sergio Eduardo de Alonso Souza Junior,Afonso Henrique de Calache,João Elias Alves,Paulo Arruda |
author_role |
author |
author2 |
Bringel,Robert William de Azevedo Nahas,Sergio Carlos Araújo,Sergio Eduardo de Alonso Souza Junior,Afonso Henrique de Calache,João Elias Alves,Paulo Arruda |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Habr-Gama,Angelita Bringel,Robert William de Azevedo Nahas,Sergio Carlos Araújo,Sergio Eduardo de Alonso Souza Junior,Afonso Henrique de Calache,João Elias Alves,Paulo Arruda |
dc.subject.por.fl_str_mv |
Bowel preparation Colonoscopy Oral solution of sodium phosphate |
topic |
Bowel preparation Colonoscopy Oral solution of sodium phosphate |
description |
METHOD: Eighty patients were prospectively randomized for precolonoscopic cleansing either with 750 ml of 10% mannitol (Group M) or 180 ml of a sodium phosphate preparation (Group NaP). Laboratory examinations before and after preparation on all patients included hemoglobin, hematocrit, sodium, potassium, phosphorous, calcium and serum osmolarity. A questionnaire was used to assess undesirable side effects and patient tolerance to the solution. The quality of preparation was assessed by the endoscopist who was unaware of the solution employed. RESULTS: Statistically significant changes were verified in serum sodium, phosphorous, potassium and calcium between the two groups, but no clinical symptoms were observed. There were no significant differences in the frequency of side effects studied. Six of the eight patients in Group NaP who had taken mannitol for a previous colonoscopy claimed better acceptance of the sodium phosphate solution. The endoscopic-blinded trial reported excellent or good bowel preparation in 85% prepared with sodium phosphate versus 82.5% for mannitol (p=0.37). CONCLUSIONS: Quality of preparation and frequency of side effects was similar in the two solutions. The smaller volume of sodium phosphate necessary for preparation seems to be related to its favorable acceptance. Nevertheless, the retention of sodium and phosphate ions contraindicates the use of sodium phosphate in patients with renal failure, cirrhosis, ascites, and heart failure. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87811999000600004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87811999000600004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0041-87811999000600004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade de Medicina / Universidade de São Paulo - FM/USP |
publisher.none.fl_str_mv |
Faculdade de Medicina / Universidade de São Paulo - FM/USP |
dc.source.none.fl_str_mv |
Revista do Hospital das Clínicas v.54 n.6 1999 reponame:Revista do Hospital das Clínicas instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista do Hospital das Clínicas |
collection |
Revista do Hospital das Clínicas |
repository.name.fl_str_mv |
Revista do Hospital das Clínicas - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||revista.hc@hcnet.usp.br |
_version_ |
1754820894006444032 |