Vascular depression in elderly: response to treatment with antidepressant associated to cholinesterase inhibitor
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Archives of Clinical Psychiatry |
Texto Completo: | https://www.revistas.usp.br/acp/article/view/17084 |
Resumo: | CONTEXT: Among neuropsychiatric disorders caused by cerebrovascular factors, vascular depression is diagnosed in a small degree by general practitioners, causing morbid-mortality increase in elderly. CASE REPORT: That is a case of a 67 year-old-man with partial response after treatment with a Selective Serotonin Receptors Inhibitor, and severe autonomic adverse effects with other antidepressants. The addition of rivastigmine to citalopram resulted in a therapeutic success, with a reduction of 23 to 7 points on the Hamilton Depressive Scale (HAM-D). DISCUSSION: The result obtained brings new perspectives to the treatment of vascular depression, providing that randomized controlled trials with larger sample sizes confirm the positive effect of the addition of a cholinesterase inhibitor to antidepressants in the treatment of these patients. |
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Archives of Clinical Psychiatry |
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Vascular depression in elderly: response to treatment with antidepressant associated to cholinesterase inhibitor Depressão vascular no idoso: resposta ao tratamento antidepressivo associado a inibidor das colinesterases Vascular depressionvascular dementiaAlzheimer's diseasestrokeneuroimagingDepressão vasculardemência vasculardoença de AlzheimerAVCneuroimagem CONTEXT: Among neuropsychiatric disorders caused by cerebrovascular factors, vascular depression is diagnosed in a small degree by general practitioners, causing morbid-mortality increase in elderly. CASE REPORT: That is a case of a 67 year-old-man with partial response after treatment with a Selective Serotonin Receptors Inhibitor, and severe autonomic adverse effects with other antidepressants. The addition of rivastigmine to citalopram resulted in a therapeutic success, with a reduction of 23 to 7 points on the Hamilton Depressive Scale (HAM-D). DISCUSSION: The result obtained brings new perspectives to the treatment of vascular depression, providing that randomized controlled trials with larger sample sizes confirm the positive effect of the addition of a cholinesterase inhibitor to antidepressants in the treatment of these patients. CONTEXTO: Entre os transtornos neuropsiquiátricos ocasionados por eventos cerebrovasculares, a depressão vascular é pouco diagnosticada por médicos não especialistas, causando aumento da morbimortalidade de pacientes idosos. CASO CLÍNICO: Trata-se de um paciente com 67 anos que apresentou resposta parcial a tratamento com inibidores da recaptura de serotonina e efeitos adversos autonômicos graves com outros antidepressivos. A adição de rivastigmina ao citalopram promoveu sucesso terapêutico, com redução de 23 para 7 pontos, na escala de Hamilton para depressão. DISCUSSÃO: O resultado obtido traz novas perspectivas para o tratamento da depressão vascular, sendo necessários ensaios clínicos controlados que evidenciem o benefício da adição dos inibidores das colinesterases aos antidepressivos no tratamento destes pacientes. Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/acp/article/view/1708410.1590/S0101-60832007000600006Revista de Psiquiatria Clínica; Vol. 34 Núm. 6 (2007); 290-293Archives of Clinical Psychiatry; v. 34 n. 6 (2007); 290-293Archives of Clinical Psychiatry; Vol. 34 No. 6 (2007); 290-2931806-938X0101-6083reponame:Archives of Clinical Psychiatryinstname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/acp/article/view/17084/19079Barcelos, RicardoFaria, JulianoGrossi, PauloAparício, Marco Antonio MoscosoBottino, Cássio M. C.info:eu-repo/semantics/openAccess2012-09-26T14:23:08Zoai:revistas.usp.br:article/17084Revistahttp://www.hcnet.usp.br/ipq/revista/index.htmlPUBhttps://old.scielo.br/oai/scielo-oai.php||archives@usp.br1806-938X0101-6083opendoar:2012-09-26T14:23:08Archives of Clinical Psychiatry - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Vascular depression in elderly: response to treatment with antidepressant associated to cholinesterase inhibitor Depressão vascular no idoso: resposta ao tratamento antidepressivo associado a inibidor das colinesterases |
title |
Vascular depression in elderly: response to treatment with antidepressant associated to cholinesterase inhibitor |
spellingShingle |
Vascular depression in elderly: response to treatment with antidepressant associated to cholinesterase inhibitor Barcelos, Ricardo Vascular depression vascular dementia Alzheimer's disease stroke neuroimaging Depressão vascular demência vascular doença de Alzheimer AVC neuroimagem |
title_short |
Vascular depression in elderly: response to treatment with antidepressant associated to cholinesterase inhibitor |
title_full |
Vascular depression in elderly: response to treatment with antidepressant associated to cholinesterase inhibitor |
title_fullStr |
Vascular depression in elderly: response to treatment with antidepressant associated to cholinesterase inhibitor |
title_full_unstemmed |
Vascular depression in elderly: response to treatment with antidepressant associated to cholinesterase inhibitor |
title_sort |
Vascular depression in elderly: response to treatment with antidepressant associated to cholinesterase inhibitor |
author |
Barcelos, Ricardo |
author_facet |
Barcelos, Ricardo Faria, Juliano Grossi, Paulo Aparício, Marco Antonio Moscoso Bottino, Cássio M. C. |
author_role |
author |
author2 |
Faria, Juliano Grossi, Paulo Aparício, Marco Antonio Moscoso Bottino, Cássio M. C. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Barcelos, Ricardo Faria, Juliano Grossi, Paulo Aparício, Marco Antonio Moscoso Bottino, Cássio M. C. |
dc.subject.por.fl_str_mv |
Vascular depression vascular dementia Alzheimer's disease stroke neuroimaging Depressão vascular demência vascular doença de Alzheimer AVC neuroimagem |
topic |
Vascular depression vascular dementia Alzheimer's disease stroke neuroimaging Depressão vascular demência vascular doença de Alzheimer AVC neuroimagem |
description |
CONTEXT: Among neuropsychiatric disorders caused by cerebrovascular factors, vascular depression is diagnosed in a small degree by general practitioners, causing morbid-mortality increase in elderly. CASE REPORT: That is a case of a 67 year-old-man with partial response after treatment with a Selective Serotonin Receptors Inhibitor, and severe autonomic adverse effects with other antidepressants. The addition of rivastigmine to citalopram resulted in a therapeutic success, with a reduction of 23 to 7 points on the Hamilton Depressive Scale (HAM-D). DISCUSSION: The result obtained brings new perspectives to the treatment of vascular depression, providing that randomized controlled trials with larger sample sizes confirm the positive effect of the addition of a cholinesterase inhibitor to antidepressants in the treatment of these patients. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/acp/article/view/17084 10.1590/S0101-60832007000600006 |
url |
https://www.revistas.usp.br/acp/article/view/17084 |
identifier_str_mv |
10.1590/S0101-60832007000600006 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/acp/article/view/17084/19079 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria |
dc.source.none.fl_str_mv |
Revista de Psiquiatria Clínica; Vol. 34 Núm. 6 (2007); 290-293 Archives of Clinical Psychiatry; v. 34 n. 6 (2007); 290-293 Archives of Clinical Psychiatry; Vol. 34 No. 6 (2007); 290-293 1806-938X 0101-6083 reponame:Archives of Clinical Psychiatry instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Archives of Clinical Psychiatry |
collection |
Archives of Clinical Psychiatry |
repository.name.fl_str_mv |
Archives of Clinical Psychiatry - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||archives@usp.br |
_version_ |
1787713901940441088 |