Somatosensory, inflammatory and pain evaluation during Orthodontic Treatment
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Tipo de documento: | Tese |
Idioma: | eng |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da USP |
Texto Completo: | https://doi.org/10.11606/T.25.2017.tde-29112021-162702 |
Resumo: | Experimental tooth movement has been shown to induce inflammation and release of chemical mediators. Inflammation can also alter nerve function that can be measured with Quantitative Sensory Testing (QST). Various authors have studied orthodontic pain and the different factors that modify it. But, to our knowledge none studied a possible individual endogenous analgesia effect on orthodontic induced-pain. The aim of the present study was to investigate the impact of orthodontic separator and short-term fixed orthodontic appliance on the somatosensory function and gingival cervicular fluid (GCF) levels of IL-1, IL-8, IL-6 and TNF-. Thirty patients were evaluated as follow: baseline, 24h-after elastomeric separator (24h-aES), 24h and 1 month after bonding the fixed appliance (aBFA) at maxillary and mandibular arch. The outcome variables were: self-reported pain, QSTs (current perception threshold, cold detection threshold, warm detection threshold, mechanical detection threshold, mechanical supra threshold and wind-up ratio, CPM and sample from the GCF in order to assess cytokines profile (IL-1, IL-8, IL-6 and TNF-). ANOVA and Tukeys post hoc analyses were performed (a = 5%). The participants were divided in two groups: G1) RESPONDERS (more than 10% decrease in WUR); G2) NON-RESPONDERS (not show more than 10% decrease in WUR). T-test for independent sample was performed. A Bonferroni correction lowered the significance level to 0.1% (p = 0.001) as the cut-off point to establish the statistical significance for the mean difference between CPM responders and non-responders. Patients were less sensitive to pin prick pain (MST) at 24h (p<0.020) and 1month-aBFA (p<0.002) when compared to baseline. Significant increases in IL-6 levels were observed 24h-aBFA (p<0.023) and in IL-1 (p<0.001) and TNF- (p<0.026) levels at 1 month-aBFA when compared to baseline values (p<0.023). There was no significant difference in somatosensory function, pain report and GCF cytokines when compared between G1 and G2. In conclusion, orthodontic-induced inflammation may have a modality specific effect on somatosensory function of the trigeminal system. In addition, elastic separators seem not an ideal model to study possible inflammatory changes following orthodontic tooth movement. Moreover, CPM efficiency may not significantly influence somatosensory function, pain intensity or released of inflammatory cytokines following orthodontic tooth movement up to 1 month. However, remained to be confirmed and further investigations are required in intraoral somatosensory assessment. |
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info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis Somatosensory, inflammatory and pain evaluation during Orthodontic Treatment Avaliação das alterações dolorosas, inflamatórias e somatossensoriais em pacientes durante tratamento ortodôntico 2017-10-05Paulo Cesar Rodrigues ContiDaniela Gamba Garib CarreiraDaniela Aparecida de Godoi GonçalvesRenata Rodrigues de Almeida PedrinFernanda Araújo SampaioUniversidade de São PauloCiências Odontológicas AplicadasUSPBR Aparelho Ortodôntico Citocinas Conditioned Pain Modulation Cytokines Dor Fluido Crevicular Gengival Gingival Crevicular Fluid Modulação de Dor Orthodontic Appliances Pain Quantitative Sensory Testing Testes Quantitativos Sensoriais Experimental tooth movement has been shown to induce inflammation and release of chemical mediators. Inflammation can also alter nerve function that can be measured with Quantitative Sensory Testing (QST). Various authors have studied orthodontic pain and the different factors that modify it. But, to our knowledge none studied a possible individual endogenous analgesia effect on orthodontic induced-pain. The aim of the present study was to investigate the impact of orthodontic separator and short-term fixed orthodontic appliance on the somatosensory function and gingival cervicular fluid (GCF) levels of IL-1, IL-8, IL-6 and TNF-. Thirty patients were evaluated as follow: baseline, 24h-after elastomeric separator (24h-aES), 24h and 1 month after bonding the fixed appliance (aBFA) at maxillary and mandibular arch. The outcome variables were: self-reported pain, QSTs (current perception threshold, cold detection threshold, warm detection threshold, mechanical detection threshold, mechanical supra threshold and wind-up ratio, CPM and sample from the GCF in order to assess cytokines profile (IL-1, IL-8, IL-6 and TNF-). ANOVA and Tukeys post hoc analyses were performed (a = 5%). The participants were divided in two groups: G1) RESPONDERS (more than 10% decrease in WUR); G2) NON-RESPONDERS (not show more than 10% decrease in WUR). T-test for independent sample was performed. A Bonferroni correction lowered the significance level to 0.1% (p = 0.001) as the cut-off point to establish the statistical significance for the mean difference between CPM responders and non-responders. Patients were less sensitive to pin prick pain (MST) at 24h (p<0.020) and 1month-aBFA (p<0.002) when compared to baseline. Significant increases in IL-6 levels were observed 24h-aBFA (p<0.023) and in IL-1 (p<0.001) and TNF- (p<0.026) levels at 1 month-aBFA when compared to baseline values (p<0.023). There was no significant difference in somatosensory function, pain report and GCF cytokines when compared between G1 and G2. In conclusion, orthodontic-induced inflammation may have a modality specific effect on somatosensory function of the trigeminal system. In addition, elastic separators seem not an ideal model to study possible inflammatory changes following orthodontic tooth movement. Moreover, CPM efficiency may not significantly influence somatosensory function, pain intensity or released of inflammatory cytokines following orthodontic tooth movement up to 1 month. However, remained to be confirmed and further investigations are required in intraoral somatosensory assessment. O movimento dentário experimental demonstrou induzir inflamação e liberação de mediadores químicos. A inflamação também pode alterar a função nervosa que pode ser medida através de testes quantitativos sensoriais (QST). Vários autores estudaram a dor ortodôntica e os diferentes fatores que a modificam. Mas, ao nosso conhecimento, não há estudos avaliando o efeito da analgesia endógena individual na dor induzida por ortodontia. O objetivo do presente estudo foi investigar o impacto do separador ortodôntico e do aparelho ortodôntico fixo de curta duração na função somatossensorial e nos níveis do fluido cervical gengival (GCF) de IL-1, IL-8, IL-6 e TNF-. Trinta pacientes foram avaliados da seguinte forma: valores basais, 24 horas após separador elástico (24h- AES), 24h e 1 mês após a ligação do aparelho fixo (aBFA) no arco maxilar e mandibular. As variáveis avaliadas foram: dor, QSTs (limiar de percepção elétrica, limiar de detecção ao frio, limiar de detecção ao quente, limiar de detecção mecânica, supralimiar mecânico e razão de somação temporal, CPM e amostra do GCF para avaliar perfil das citocinas ( IL-1, IL-8, IL-6 e TNF-). A ANOVA e as análises post hoc de Tukey foram realizadas (a = 5%). Os participantes foram divididos em dois grupos: G1) CPM-RESPONDENTES (diminuição de mais de 10% em WUR); G2) CPM-NÃO RESPONDENTES (não mostra mais de 10% de diminuição na WUR). Foi realizado teste T para amostra independente. Uma correção de Bonferroni reduziu o nível de significância para 0,1% (p = 0,001) como ponto de corte para estabelecer a significância estatística para a diferença média entre G1 o G2. Os pacientes eram menos sensíveis à dor de pin (MST) às 24h (p <0,020) e 1 mês-aBFA (p <0,002) quando comparado à linha de base. Observaram-se aumentos significativos nos níveis de IL-6 níveis 24h-aBFA (p <0,023) e nos níveis de IL-1 (p <0,001) e TNF- (p <0,026) em 1 mês-aBFA quando comparados aos valores basais (p < 0,023). Não houve diferença significativa na função somatossensorial, no relatório da dor e citocinas do FCG quando comparadas entre G1 e G2. Em conclusão, a inflamação induzida por ortodontia pode ter um efeito de modalidade específico na função somatossensorial do sistema trigeminal. Além disso, os separadores elásticos não parecem ser um modelo ideal para estudar possíveis alterações inflamatórias após o movimento dentário ortodôntico. Além disso, a eficiência de CPM pode não influenciar significativamente a função somatossensorial, intensidade da dor ou liberação de citocinas inflamatórias após o movimento dentário ortodôntico até 1 mês. No entanto, outras investigações são necessárias na avaliação somatossensorial intraoral. https://doi.org/10.11606/T.25.2017.tde-29112021-162702info:eu-repo/semantics/openAccessengreponame:Biblioteca Digital de Teses e Dissertações da USPinstname:Universidade de São Paulo (USP)instacron:USP2023-12-21T20:25:12Zoai:teses.usp.br:tde-29112021-162702Biblioteca Digital de Teses e Dissertaçõeshttp://www.teses.usp.br/PUBhttp://www.teses.usp.br/cgi-bin/mtd2br.plvirginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.bropendoar:27212023-12-22T13:30:50.491283Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)false |
dc.title.en.fl_str_mv |
Somatosensory, inflammatory and pain evaluation during Orthodontic Treatment |
dc.title.alternative.pt.fl_str_mv |
Avaliação das alterações dolorosas, inflamatórias e somatossensoriais em pacientes durante tratamento ortodôntico |
title |
Somatosensory, inflammatory and pain evaluation during Orthodontic Treatment |
spellingShingle |
Somatosensory, inflammatory and pain evaluation during Orthodontic Treatment Fernanda Araújo Sampaio |
title_short |
Somatosensory, inflammatory and pain evaluation during Orthodontic Treatment |
title_full |
Somatosensory, inflammatory and pain evaluation during Orthodontic Treatment |
title_fullStr |
Somatosensory, inflammatory and pain evaluation during Orthodontic Treatment |
title_full_unstemmed |
Somatosensory, inflammatory and pain evaluation during Orthodontic Treatment |
title_sort |
Somatosensory, inflammatory and pain evaluation during Orthodontic Treatment |
author |
Fernanda Araújo Sampaio |
author_facet |
Fernanda Araújo Sampaio |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Paulo Cesar Rodrigues Conti |
dc.contributor.referee1.fl_str_mv |
Daniela Gamba Garib Carreira |
dc.contributor.referee2.fl_str_mv |
Daniela Aparecida de Godoi Gonçalves |
dc.contributor.referee3.fl_str_mv |
Renata Rodrigues de Almeida Pedrin |
dc.contributor.author.fl_str_mv |
Fernanda Araújo Sampaio |
contributor_str_mv |
Paulo Cesar Rodrigues Conti Daniela Gamba Garib Carreira Daniela Aparecida de Godoi Gonçalves Renata Rodrigues de Almeida Pedrin |
description |
Experimental tooth movement has been shown to induce inflammation and release of chemical mediators. Inflammation can also alter nerve function that can be measured with Quantitative Sensory Testing (QST). Various authors have studied orthodontic pain and the different factors that modify it. But, to our knowledge none studied a possible individual endogenous analgesia effect on orthodontic induced-pain. The aim of the present study was to investigate the impact of orthodontic separator and short-term fixed orthodontic appliance on the somatosensory function and gingival cervicular fluid (GCF) levels of IL-1, IL-8, IL-6 and TNF-. Thirty patients were evaluated as follow: baseline, 24h-after elastomeric separator (24h-aES), 24h and 1 month after bonding the fixed appliance (aBFA) at maxillary and mandibular arch. The outcome variables were: self-reported pain, QSTs (current perception threshold, cold detection threshold, warm detection threshold, mechanical detection threshold, mechanical supra threshold and wind-up ratio, CPM and sample from the GCF in order to assess cytokines profile (IL-1, IL-8, IL-6 and TNF-). ANOVA and Tukeys post hoc analyses were performed (a = 5%). The participants were divided in two groups: G1) RESPONDERS (more than 10% decrease in WUR); G2) NON-RESPONDERS (not show more than 10% decrease in WUR). T-test for independent sample was performed. A Bonferroni correction lowered the significance level to 0.1% (p = 0.001) as the cut-off point to establish the statistical significance for the mean difference between CPM responders and non-responders. Patients were less sensitive to pin prick pain (MST) at 24h (p<0.020) and 1month-aBFA (p<0.002) when compared to baseline. Significant increases in IL-6 levels were observed 24h-aBFA (p<0.023) and in IL-1 (p<0.001) and TNF- (p<0.026) levels at 1 month-aBFA when compared to baseline values (p<0.023). There was no significant difference in somatosensory function, pain report and GCF cytokines when compared between G1 and G2. In conclusion, orthodontic-induced inflammation may have a modality specific effect on somatosensory function of the trigeminal system. In addition, elastic separators seem not an ideal model to study possible inflammatory changes following orthodontic tooth movement. Moreover, CPM efficiency may not significantly influence somatosensory function, pain intensity or released of inflammatory cytokines following orthodontic tooth movement up to 1 month. However, remained to be confirmed and further investigations are required in intraoral somatosensory assessment. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-10-05 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.11606/T.25.2017.tde-29112021-162702 |
url |
https://doi.org/10.11606/T.25.2017.tde-29112021-162702 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo |
dc.publisher.program.fl_str_mv |
Ciências Odontológicas Aplicadas |
dc.publisher.initials.fl_str_mv |
USP |
dc.publisher.country.fl_str_mv |
BR |
publisher.none.fl_str_mv |
Universidade de São Paulo |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da USP instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Biblioteca Digital de Teses e Dissertações da USP |
collection |
Biblioteca Digital de Teses e Dissertações da USP |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
virginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.br |
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1794503147670994944 |