Inflammatory mediators in nasal lavage among school-age children from urban and rural areas in São Paulo, Brazil

Detalhes bibliográficos
Autor(a) principal: Galvão,Clóvis Eduardo Santos
Data de Publicação: 2004
Outros Autores: Saldiva,Paulo Hilário Nascimento, Kalil Filho,Jorge Elias, Castro,Fábio Fernandes Morato
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000500005
Resumo: CONTEXT: Some studies have shown that inflammatory processes in the nasal air passages may reflect or affect those in the lower airways. We decided to indirectly assess the inflammatory status of the nasal airways in two groups of children with different sensitization rates to aeroallergens. OBJECTIVE: To compare the inflammatory activity in the nasal airways, through the determination of mediators in nasal lavage fluid in two distinct populations. TYPE OF STUDY: Cross-sectional study. SETTING: Two public elementary schools, one in an urban setting and the other in a rural setting of the State of São Paulo, Brazil. METHODS: Two groups of 40 elementary school children with different sensitization rates to aeroallergens were formed. Samples of nasal lavage fluid were assessed for eosinophil cationic protein (ECP) and tryptase. Non-parametric tests were used for statistical analysis. RESULTS: Significantly higher levels of ECP were observed among students living in the urban area than those in the rural area (p < 0.05). No significant difference in the tryptase levels was observed. Also, the urban children who were sensitized to aeroallergens presented higher levels of ECP in nasal mucosa than the non-sensitized children, while this difference was not observed among the rural children. DISCUSSION: The lack of mast cell activity and increased eosinophil degranulation revealed a chronic inflammatory state in the nasal air passages. The higher eosinophil activity in the urban area, coinciding with higher sensitization to aeroallergens, suggests that there must be some factors in the urban area that can modulate airway inflammation by influencing the activation of inflammatory cells. CONCLUSION: Our findings showed that there was no difference in the concentrations of tryptase in nasal lavage fluids between the two studied groups. However, the children from the urban area presented with higher concentrations of eosinophil cationic protein than did those from the rural area. Also, the urban children who were sensitized to aeroallergens presented with greater concentrations of eosinophil cationic protein in nasal mucosa than the non-sensitized children, while this difference was not observed among the rural children.
id APM-1_a1438862cbbdc6fbe163d4efe49b9182
oai_identifier_str oai:scielo:S1516-31802004000500005
network_acronym_str APM-1
network_name_str São Paulo medical journal (Online)
repository_id_str
spelling Inflammatory mediators in nasal lavage among school-age children from urban and rural areas in São Paulo, BrazilNasal lavage fluidHypersensitivityAllergensInflammation mediatorsInflammationCONTEXT: Some studies have shown that inflammatory processes in the nasal air passages may reflect or affect those in the lower airways. We decided to indirectly assess the inflammatory status of the nasal airways in two groups of children with different sensitization rates to aeroallergens. OBJECTIVE: To compare the inflammatory activity in the nasal airways, through the determination of mediators in nasal lavage fluid in two distinct populations. TYPE OF STUDY: Cross-sectional study. SETTING: Two public elementary schools, one in an urban setting and the other in a rural setting of the State of São Paulo, Brazil. METHODS: Two groups of 40 elementary school children with different sensitization rates to aeroallergens were formed. Samples of nasal lavage fluid were assessed for eosinophil cationic protein (ECP) and tryptase. Non-parametric tests were used for statistical analysis. RESULTS: Significantly higher levels of ECP were observed among students living in the urban area than those in the rural area (p < 0.05). No significant difference in the tryptase levels was observed. Also, the urban children who were sensitized to aeroallergens presented higher levels of ECP in nasal mucosa than the non-sensitized children, while this difference was not observed among the rural children. DISCUSSION: The lack of mast cell activity and increased eosinophil degranulation revealed a chronic inflammatory state in the nasal air passages. The higher eosinophil activity in the urban area, coinciding with higher sensitization to aeroallergens, suggests that there must be some factors in the urban area that can modulate airway inflammation by influencing the activation of inflammatory cells. CONCLUSION: Our findings showed that there was no difference in the concentrations of tryptase in nasal lavage fluids between the two studied groups. However, the children from the urban area presented with higher concentrations of eosinophil cationic protein than did those from the rural area. Also, the urban children who were sensitized to aeroallergens presented with greater concentrations of eosinophil cationic protein in nasal mucosa than the non-sensitized children, while this difference was not observed among the rural children.Associação Paulista de Medicina - APM2004-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000500005Sao Paulo Medical Journal v.122 n.5 2004reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31802004000500005info:eu-repo/semantics/openAccessGalvão,Clóvis Eduardo SantosSaldiva,Paulo Hilário NascimentoKalil Filho,Jorge EliasCastro,Fábio Fernandes Moratoeng2004-11-10T00:00:00Zoai:scielo:S1516-31802004000500005Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2004-11-10T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Inflammatory mediators in nasal lavage among school-age children from urban and rural areas in São Paulo, Brazil
title Inflammatory mediators in nasal lavage among school-age children from urban and rural areas in São Paulo, Brazil
spellingShingle Inflammatory mediators in nasal lavage among school-age children from urban and rural areas in São Paulo, Brazil
Galvão,Clóvis Eduardo Santos
Nasal lavage fluid
Hypersensitivity
Allergens
Inflammation mediators
Inflammation
title_short Inflammatory mediators in nasal lavage among school-age children from urban and rural areas in São Paulo, Brazil
title_full Inflammatory mediators in nasal lavage among school-age children from urban and rural areas in São Paulo, Brazil
title_fullStr Inflammatory mediators in nasal lavage among school-age children from urban and rural areas in São Paulo, Brazil
title_full_unstemmed Inflammatory mediators in nasal lavage among school-age children from urban and rural areas in São Paulo, Brazil
title_sort Inflammatory mediators in nasal lavage among school-age children from urban and rural areas in São Paulo, Brazil
author Galvão,Clóvis Eduardo Santos
author_facet Galvão,Clóvis Eduardo Santos
Saldiva,Paulo Hilário Nascimento
Kalil Filho,Jorge Elias
Castro,Fábio Fernandes Morato
author_role author
author2 Saldiva,Paulo Hilário Nascimento
Kalil Filho,Jorge Elias
Castro,Fábio Fernandes Morato
author2_role author
author
author
dc.contributor.author.fl_str_mv Galvão,Clóvis Eduardo Santos
Saldiva,Paulo Hilário Nascimento
Kalil Filho,Jorge Elias
Castro,Fábio Fernandes Morato
dc.subject.por.fl_str_mv Nasal lavage fluid
Hypersensitivity
Allergens
Inflammation mediators
Inflammation
topic Nasal lavage fluid
Hypersensitivity
Allergens
Inflammation mediators
Inflammation
description CONTEXT: Some studies have shown that inflammatory processes in the nasal air passages may reflect or affect those in the lower airways. We decided to indirectly assess the inflammatory status of the nasal airways in two groups of children with different sensitization rates to aeroallergens. OBJECTIVE: To compare the inflammatory activity in the nasal airways, through the determination of mediators in nasal lavage fluid in two distinct populations. TYPE OF STUDY: Cross-sectional study. SETTING: Two public elementary schools, one in an urban setting and the other in a rural setting of the State of São Paulo, Brazil. METHODS: Two groups of 40 elementary school children with different sensitization rates to aeroallergens were formed. Samples of nasal lavage fluid were assessed for eosinophil cationic protein (ECP) and tryptase. Non-parametric tests were used for statistical analysis. RESULTS: Significantly higher levels of ECP were observed among students living in the urban area than those in the rural area (p < 0.05). No significant difference in the tryptase levels was observed. Also, the urban children who were sensitized to aeroallergens presented higher levels of ECP in nasal mucosa than the non-sensitized children, while this difference was not observed among the rural children. DISCUSSION: The lack of mast cell activity and increased eosinophil degranulation revealed a chronic inflammatory state in the nasal air passages. The higher eosinophil activity in the urban area, coinciding with higher sensitization to aeroallergens, suggests that there must be some factors in the urban area that can modulate airway inflammation by influencing the activation of inflammatory cells. CONCLUSION: Our findings showed that there was no difference in the concentrations of tryptase in nasal lavage fluids between the two studied groups. However, the children from the urban area presented with higher concentrations of eosinophil cationic protein than did those from the rural area. Also, the urban children who were sensitized to aeroallergens presented with greater concentrations of eosinophil cationic protein in nasal mucosa than the non-sensitized children, while this difference was not observed among the rural children.
publishDate 2004
dc.date.none.fl_str_mv 2004-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000500005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000500005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-31802004000500005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv Sao Paulo Medical Journal v.122 n.5 2004
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
_version_ 1754209260896518144