Pathogenesis of chronic Chagas' myocarditis

Detalhes bibliográficos
Autor(a) principal: Rossi, Marcos A.
Data de Publicação: 1995
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: https://periodicosapm.emnuvens.com.br/spmj/article/view/1597
Resumo: The pathogenesis of chronic Chagas' myocarditis is still not completely understood. Several theories have been advanced: 1)direct tissue destruction by Trypanosoma cruzi; 2) neurogenic theory; 3) anti-heart immune reactions; and 4) microvascular disease. We present herein a dynamic alternative hypothesis. We believe that the development of myocarditis is related to progressive and additive focal cellular necrosis, and associated reactive and reparative myocardial fibrosis and surrounding myocyte hypertrophy. These processes may be initiated and perpetuated by anti immune factors and alterations in the myocardial microcirculation. The destruction of the ganglion cells of the heart may be involved in the patho-clinical evolution of chronic Chagas' cardiopathy. This could imply future therapeutic strategies in the management of chronic Chagas' patients to enhance medical treatment and, hopefully, improve prognosis.
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spelling Pathogenesis of chronic Chagas' myocarditis MyocarditisChagas's diseaseThe pathogenesis of chronic Chagas' myocarditis is still not completely understood. Several theories have been advanced: 1)direct tissue destruction by Trypanosoma cruzi; 2) neurogenic theory; 3) anti-heart immune reactions; and 4) microvascular disease. We present herein a dynamic alternative hypothesis. We believe that the development of myocarditis is related to progressive and additive focal cellular necrosis, and associated reactive and reparative myocardial fibrosis and surrounding myocyte hypertrophy. These processes may be initiated and perpetuated by anti immune factors and alterations in the myocardial microcirculation. The destruction of the ganglion cells of the heart may be involved in the patho-clinical evolution of chronic Chagas' cardiopathy. This could imply future therapeutic strategies in the management of chronic Chagas' patients to enhance medical treatment and, hopefully, improve prognosis.A patogênese da miocardite chagásica crônica permanece incompletamente compreendida. Diferentes hipóteses têm sido propostas: (1) lesão direta do tecido pelo Trypanosoma cruzi; (2) teoria neurogênica; (3) reações imunológicas antimiocárdio; e (4) doença microvascular. Apresentamos, no presente trabalho, uma hipótese alternativa. Acreditamos que o desenvolvimento da miocardite está relacionado à necrose celular focal progressiva e acumulativa, associada à fibrose intersticial reparativa e reativa e hipertrofia miocitária circunjacente. Esses processos seriam iniciados e perpetuados por fatores auto-imunes e alterações na microcirculação do miocárdio. As alterações intrínsecas do sistema nervoso autônomo estariam implicadas no contexto global da evolução clínico-patológica da cardiopatia chagásica crônica. O mecanismo fisiopatogênico proposto teria implicações em futuras estratégias terapêuticas no tratamento do paciente chagásico crônico visando otimizar o tratamento médico e auspiciosamente melhorar o prognóstico.São Paulo Medical JournalSão Paulo Medical Journal1995-03-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicosapm.emnuvens.com.br/spmj/article/view/1597São Paulo Medical Journal; Vol. 113 No. 2 (1995); 750-756São Paulo Medical Journal; v. 113 n. 2 (1995); 750-7561806-9460reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APMenghttps://periodicosapm.emnuvens.com.br/spmj/article/view/1597/1491https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRossi, Marcos A.2023-09-12T10:53:33Zoai:ojs.diagnosticoetratamento.emnuvens.com.br:article/1597Revistahttp://www.scielo.br/spmjPUBhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2023-09-12T10:53:33São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Pathogenesis of chronic Chagas' myocarditis
title Pathogenesis of chronic Chagas' myocarditis
spellingShingle Pathogenesis of chronic Chagas' myocarditis
Rossi, Marcos A.
Myocarditis
Chagas's disease
title_short Pathogenesis of chronic Chagas' myocarditis
title_full Pathogenesis of chronic Chagas' myocarditis
title_fullStr Pathogenesis of chronic Chagas' myocarditis
title_full_unstemmed Pathogenesis of chronic Chagas' myocarditis
title_sort Pathogenesis of chronic Chagas' myocarditis
author Rossi, Marcos A.
author_facet Rossi, Marcos A.
author_role author
dc.contributor.author.fl_str_mv Rossi, Marcos A.
dc.subject.por.fl_str_mv Myocarditis
Chagas's disease
topic Myocarditis
Chagas's disease
description The pathogenesis of chronic Chagas' myocarditis is still not completely understood. Several theories have been advanced: 1)direct tissue destruction by Trypanosoma cruzi; 2) neurogenic theory; 3) anti-heart immune reactions; and 4) microvascular disease. We present herein a dynamic alternative hypothesis. We believe that the development of myocarditis is related to progressive and additive focal cellular necrosis, and associated reactive and reparative myocardial fibrosis and surrounding myocyte hypertrophy. These processes may be initiated and perpetuated by anti immune factors and alterations in the myocardial microcirculation. The destruction of the ganglion cells of the heart may be involved in the patho-clinical evolution of chronic Chagas' cardiopathy. This could imply future therapeutic strategies in the management of chronic Chagas' patients to enhance medical treatment and, hopefully, improve prognosis.
publishDate 1995
dc.date.none.fl_str_mv 1995-03-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicosapm.emnuvens.com.br/spmj/article/view/1597
url https://periodicosapm.emnuvens.com.br/spmj/article/view/1597
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicosapm.emnuvens.com.br/spmj/article/view/1597/1491
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv São Paulo Medical Journal
São Paulo Medical Journal
publisher.none.fl_str_mv São Paulo Medical Journal
São Paulo Medical Journal
dc.source.none.fl_str_mv São Paulo Medical Journal; Vol. 113 No. 2 (1995); 750-756
São Paulo Medical Journal; v. 113 n. 2 (1995); 750-756
1806-9460
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
_version_ 1825135065959497728

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