Pathogenesis of chronic Chagas' myocarditis
Autor(a) principal: | |
---|---|
Data de Publicação: | 1995 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | São Paulo medical journal (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200004 |
Resumo: | The pathogenesis of chronic Chagas' myocarditis is still not completely understood. Several theories have been advanced: 1)direct tissue destruction by Trypanosoma cruzi; 2) neurogenic theory; 3) anti-heart immune reactions; and 4) microvascular disease. We present herein a dynamic alternative hypothesis. We believe that the development of myocarditis is related to progressive and additive focal cellular necrosis, and associated reactive and reparative myocardial fibrosis and surrounding myocyte hypertrophy. These processes may be initiated and perpetuated by anti immune factors and alterations in the myocardial microcirculation. The destruction of the ganglion cells of the heart may be involved in the patho-clinical evolution of chronic Chagas' cardiopathy. This could imply future therapeutic strategies in the management of chronic Chagas' patients to enhance medical treatment and, hopefully, improve prognosis. |
id |
APM-1_d433f10ecf0be280fcd9aa4dd6c3dd2b |
---|---|
oai_identifier_str |
oai:scielo:S1516-31801995000200004 |
network_acronym_str |
APM-1 |
network_name_str |
São Paulo medical journal (Online) |
repository_id_str |
|
spelling |
Pathogenesis of chronic Chagas' myocarditisMyocarditisChagas's diseaseThe pathogenesis of chronic Chagas' myocarditis is still not completely understood. Several theories have been advanced: 1)direct tissue destruction by Trypanosoma cruzi; 2) neurogenic theory; 3) anti-heart immune reactions; and 4) microvascular disease. We present herein a dynamic alternative hypothesis. We believe that the development of myocarditis is related to progressive and additive focal cellular necrosis, and associated reactive and reparative myocardial fibrosis and surrounding myocyte hypertrophy. These processes may be initiated and perpetuated by anti immune factors and alterations in the myocardial microcirculation. The destruction of the ganglion cells of the heart may be involved in the patho-clinical evolution of chronic Chagas' cardiopathy. This could imply future therapeutic strategies in the management of chronic Chagas' patients to enhance medical treatment and, hopefully, improve prognosis.Associação Paulista de Medicina - APM1995-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200004Sao Paulo Medical Journal v.113 n.2 1995reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31801995000200004info:eu-repo/semantics/openAccessRossi,Marcos A.eng2009-05-28T00:00:00Zoai:scielo:S1516-31801995000200004Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2009-05-28T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse |
dc.title.none.fl_str_mv |
Pathogenesis of chronic Chagas' myocarditis |
title |
Pathogenesis of chronic Chagas' myocarditis |
spellingShingle |
Pathogenesis of chronic Chagas' myocarditis Rossi,Marcos A. Myocarditis Chagas's disease |
title_short |
Pathogenesis of chronic Chagas' myocarditis |
title_full |
Pathogenesis of chronic Chagas' myocarditis |
title_fullStr |
Pathogenesis of chronic Chagas' myocarditis |
title_full_unstemmed |
Pathogenesis of chronic Chagas' myocarditis |
title_sort |
Pathogenesis of chronic Chagas' myocarditis |
author |
Rossi,Marcos A. |
author_facet |
Rossi,Marcos A. |
author_role |
author |
dc.contributor.author.fl_str_mv |
Rossi,Marcos A. |
dc.subject.por.fl_str_mv |
Myocarditis Chagas's disease |
topic |
Myocarditis Chagas's disease |
description |
The pathogenesis of chronic Chagas' myocarditis is still not completely understood. Several theories have been advanced: 1)direct tissue destruction by Trypanosoma cruzi; 2) neurogenic theory; 3) anti-heart immune reactions; and 4) microvascular disease. We present herein a dynamic alternative hypothesis. We believe that the development of myocarditis is related to progressive and additive focal cellular necrosis, and associated reactive and reparative myocardial fibrosis and surrounding myocyte hypertrophy. These processes may be initiated and perpetuated by anti immune factors and alterations in the myocardial microcirculation. The destruction of the ganglion cells of the heart may be involved in the patho-clinical evolution of chronic Chagas' cardiopathy. This could imply future therapeutic strategies in the management of chronic Chagas' patients to enhance medical treatment and, hopefully, improve prognosis. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-31801995000200004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
Sao Paulo Medical Journal v.113 n.2 1995 reponame:São Paulo medical journal (Online) instname:Associação Paulista de Medicina instacron:APM |
instname_str |
Associação Paulista de Medicina |
instacron_str |
APM |
institution |
APM |
reponame_str |
São Paulo medical journal (Online) |
collection |
São Paulo medical journal (Online) |
repository.name.fl_str_mv |
São Paulo medical journal (Online) - Associação Paulista de Medicina |
repository.mail.fl_str_mv |
revistas@apm.org.br |
_version_ |
1754209259192582144 |