Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae

Detalhes bibliográficos
Autor(a) principal: Nogueira,Keite da Silva
Data de Publicação: 2011
Outros Autores: Daur,Alessandra Vale, Reason,Iara Taborda de Messias, Gales,Ana Cristina, Costa,Libera Maria Dalla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200014
Resumo: The objective of this study was to evaluate the susceptibility to cefepime of a large group of ESBL- producing enterobacteria recently isolated in a Brazilian teaching hospital . The study included 280 strains of ESBL-producing enterobacteria, isolated between 2005 and 2008. The presence of the genes blaCTX-M, blaTEM and blaSHV was determined by PCR and confirmed by nucleotide sequencing. Susceptibility testing for cefepime was performed by disc-diffusion, agar dilution method and E-test®. Among the isolates, 34 (12.1%) presented a cefepime inhibition zone &gt; 21 and MIC < 8 mg/L by agar dilution and E-strip methods. The use of cefepime for the treatment of infections caused by ESBL-producing bacteria has been controversial. Some studies of PD/PK show the probability of achieving the required PD parameters for cefepime, when the MICs were < 8 mg/L, whereas others have reported therapeutic failure with the same MIC. Additional data is essential to come to terms about the report and treatment with cefepime in ESBL-producing organisms especially when these microorganisms are isolated from sterile sites and from critically ill patients.
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spelling Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceaeenterobacteriaceaebeta-lactamasescephalosporin resistanceThe objective of this study was to evaluate the susceptibility to cefepime of a large group of ESBL- producing enterobacteria recently isolated in a Brazilian teaching hospital . The study included 280 strains of ESBL-producing enterobacteria, isolated between 2005 and 2008. The presence of the genes blaCTX-M, blaTEM and blaSHV was determined by PCR and confirmed by nucleotide sequencing. Susceptibility testing for cefepime was performed by disc-diffusion, agar dilution method and E-test®. Among the isolates, 34 (12.1%) presented a cefepime inhibition zone &gt; 21 and MIC < 8 mg/L by agar dilution and E-strip methods. The use of cefepime for the treatment of infections caused by ESBL-producing bacteria has been controversial. Some studies of PD/PK show the probability of achieving the required PD parameters for cefepime, when the MICs were < 8 mg/L, whereas others have reported therapeutic failure with the same MIC. Additional data is essential to come to terms about the report and treatment with cefepime in ESBL-producing organisms especially when these microorganisms are isolated from sterile sites and from critically ill patients.Brazilian Society of Infectious Diseases2011-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200014Brazilian Journal of Infectious Diseases v.15 n.2 2011reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702011000200014info:eu-repo/semantics/openAccessNogueira,Keite da SilvaDaur,Alessandra ValeReason,Iara Taborda de MessiasGales,Ana CristinaCosta,Libera Maria Dallaeng2011-04-06T00:00:00Zoai:scielo:S1413-86702011000200014Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2011-04-06T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae
title Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae
spellingShingle Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae
Nogueira,Keite da Silva
enterobacteriaceae
beta-lactamases
cephalosporin resistance
title_short Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae
title_full Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae
title_fullStr Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae
title_full_unstemmed Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae
title_sort Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae
author Nogueira,Keite da Silva
author_facet Nogueira,Keite da Silva
Daur,Alessandra Vale
Reason,Iara Taborda de Messias
Gales,Ana Cristina
Costa,Libera Maria Dalla
author_role author
author2 Daur,Alessandra Vale
Reason,Iara Taborda de Messias
Gales,Ana Cristina
Costa,Libera Maria Dalla
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Nogueira,Keite da Silva
Daur,Alessandra Vale
Reason,Iara Taborda de Messias
Gales,Ana Cristina
Costa,Libera Maria Dalla
dc.subject.por.fl_str_mv enterobacteriaceae
beta-lactamases
cephalosporin resistance
topic enterobacteriaceae
beta-lactamases
cephalosporin resistance
description The objective of this study was to evaluate the susceptibility to cefepime of a large group of ESBL- producing enterobacteria recently isolated in a Brazilian teaching hospital . The study included 280 strains of ESBL-producing enterobacteria, isolated between 2005 and 2008. The presence of the genes blaCTX-M, blaTEM and blaSHV was determined by PCR and confirmed by nucleotide sequencing. Susceptibility testing for cefepime was performed by disc-diffusion, agar dilution method and E-test®. Among the isolates, 34 (12.1%) presented a cefepime inhibition zone &gt; 21 and MIC < 8 mg/L by agar dilution and E-strip methods. The use of cefepime for the treatment of infections caused by ESBL-producing bacteria has been controversial. Some studies of PD/PK show the probability of achieving the required PD parameters for cefepime, when the MICs were < 8 mg/L, whereas others have reported therapeutic failure with the same MIC. Additional data is essential to come to terms about the report and treatment with cefepime in ESBL-producing organisms especially when these microorganisms are isolated from sterile sites and from critically ill patients.
publishDate 2011
dc.date.none.fl_str_mv 2011-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1413-86702011000200014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.15 n.2 2011
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
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