Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Motriz (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-65742017000500202 |
Resumo: | Abstract Glucose uptake is an important phenomenon for cell homeostasis and for organism health. Under resting conditions, skeletal muscle is dependent on insulin to promote glucose uptake.Insulin, after binding to its membrane receptor, triggers a cascade of intracellular reactions culminating in activation of the glucose transporter 4, GLUT4, among other outcomes.This transporter migrates to the plasma membrane and assists in glucose internalization.However, under special conditions such as physical exercise, alterations in the levels of intracellular molecules such as ATP and calcium actto regulate GLUT4 translocation and glucose uptake in skeletal muscle, regardless of insulinlevels.Regular physical exercise, due to stimulating pathways related to glucose uptake, is an important non-pharmacological intervention for improving glycemic control in obese and diabetic patients. In this mini-review the main mechanisms involved in glucose uptake in skeletal muscle in response to muscle contraction will be investigated. |
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Motriz (Online) |
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Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exerciseexerciseskeletal muscleglucose uptakeGLUT4Abstract Glucose uptake is an important phenomenon for cell homeostasis and for organism health. Under resting conditions, skeletal muscle is dependent on insulin to promote glucose uptake.Insulin, after binding to its membrane receptor, triggers a cascade of intracellular reactions culminating in activation of the glucose transporter 4, GLUT4, among other outcomes.This transporter migrates to the plasma membrane and assists in glucose internalization.However, under special conditions such as physical exercise, alterations in the levels of intracellular molecules such as ATP and calcium actto regulate GLUT4 translocation and glucose uptake in skeletal muscle, regardless of insulinlevels.Regular physical exercise, due to stimulating pathways related to glucose uptake, is an important non-pharmacological intervention for improving glycemic control in obese and diabetic patients. In this mini-review the main mechanisms involved in glucose uptake in skeletal muscle in response to muscle contraction will be investigated.Universidade Estadual Paulista2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-65742017000500202Motriz: Revista de Educação Física v.23 n.spe 2017reponame:Motriz (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/s1980-6574201700si0004info:eu-repo/semantics/openAccessPereira,Rodrigo MartinsMoura,Leandro Pereira deMuñoz,Vitor RosettoSilva,Adelino Sanchez Ramos daGaspar,Rodrigo StellzerRopelle,Eduardo RochetePauli,José Rodrigoeng2017-04-26T00:00:00Zoai:scielo:S1980-65742017000500202Revistahttp://www.periodicos.rc.biblioteca.unesp.br/index.php/motrizPUBhttps://old.scielo.br/oai/scielo-oai.phpmotriz@rc.unesp.br||mauerber@rc.unesp.br||azanesco@rc.unesp.br1980-65741415-9805opendoar:2022-11-08T16:30:33.208088Motriz (Online) - Universidade Estadual Paulista (UNESP)true |
dc.title.none.fl_str_mv |
Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise |
title |
Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise |
spellingShingle |
Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise Pereira,Rodrigo Martins exercise skeletal muscle glucose uptake GLUT4 |
title_short |
Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise |
title_full |
Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise |
title_fullStr |
Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise |
title_full_unstemmed |
Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise |
title_sort |
Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise |
author |
Pereira,Rodrigo Martins |
author_facet |
Pereira,Rodrigo Martins Moura,Leandro Pereira de Muñoz,Vitor Rosetto Silva,Adelino Sanchez Ramos da Gaspar,Rodrigo Stellzer Ropelle,Eduardo Rochete Pauli,José Rodrigo |
author_role |
author |
author2 |
Moura,Leandro Pereira de Muñoz,Vitor Rosetto Silva,Adelino Sanchez Ramos da Gaspar,Rodrigo Stellzer Ropelle,Eduardo Rochete Pauli,José Rodrigo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Pereira,Rodrigo Martins Moura,Leandro Pereira de Muñoz,Vitor Rosetto Silva,Adelino Sanchez Ramos da Gaspar,Rodrigo Stellzer Ropelle,Eduardo Rochete Pauli,José Rodrigo |
dc.subject.por.fl_str_mv |
exercise skeletal muscle glucose uptake GLUT4 |
topic |
exercise skeletal muscle glucose uptake GLUT4 |
description |
Abstract Glucose uptake is an important phenomenon for cell homeostasis and for organism health. Under resting conditions, skeletal muscle is dependent on insulin to promote glucose uptake.Insulin, after binding to its membrane receptor, triggers a cascade of intracellular reactions culminating in activation of the glucose transporter 4, GLUT4, among other outcomes.This transporter migrates to the plasma membrane and assists in glucose internalization.However, under special conditions such as physical exercise, alterations in the levels of intracellular molecules such as ATP and calcium actto regulate GLUT4 translocation and glucose uptake in skeletal muscle, regardless of insulinlevels.Regular physical exercise, due to stimulating pathways related to glucose uptake, is an important non-pharmacological intervention for improving glycemic control in obese and diabetic patients. In this mini-review the main mechanisms involved in glucose uptake in skeletal muscle in response to muscle contraction will be investigated. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-65742017000500202 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-65742017000500202 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1980-6574201700si0004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista |
publisher.none.fl_str_mv |
Universidade Estadual Paulista |
dc.source.none.fl_str_mv |
Motriz: Revista de Educação Física v.23 n.spe 2017 reponame:Motriz (Online) instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Motriz (Online) |
collection |
Motriz (Online) |
repository.name.fl_str_mv |
Motriz (Online) - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
motriz@rc.unesp.br||mauerber@rc.unesp.br||azanesco@rc.unesp.br |
_version_ |
1788170935564500992 |