Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, Brazil

Detalhes bibliográficos
Autor(a) principal: Quevedo,Lucas S.
Data de Publicação: 2022
Outros Autores: Cristo,Thierry G., Cunha,Anna L.O., Hemckmeier,Deise, Marian,Lucas, Medeiros,Amanda L.V., Pandolfo,Gustavo W., Casagrande,Renata A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Pesquisa Veterinária Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2022000100234
Resumo: ABSTRACT: Poisoning by Trema micrantha commonly causes hepatocellular necrosis in cattle, sheep, and goats and edema and cerebral hemorrhage in horses. This plant can cause toxic pneumopathy in sheep, and there is only one report of the natural form and one of the experimental form in the State of Rio Grande do Sul. This study aimed to report an outbreak of the respiratory form of natural poisoning by T. micrantha in sheep. Six sheep developed clinical respiratory signs after consumption of the plant and four of them died and two recovered after treatment with dexamethasone. The sheep presented tachypnea, noisy breathing, edema of the face, eyelids, and vulva, and subcutaneous emphysema on the face and neck. Necropsy (Sheep 2, 3, and 4) showed uncollapsed, heavy, diffuse red lungs with evident costal impressions and a moderate amount of serosanguineous fluid flowed at section. The liver had a moderate diffuse evident lobular pattern. The histopathology of the lungs of the three necropsied sheep showed congestion and edema with the formation of hyaline membranes within accentuated diffuse alveoli, in addition to thickening of the alveolar septa due to mild to moderate diffuse type II pneumocyte hyperplasia and also mild to moderate diffuse infiltrate of macrophages, lymphocytes, plasma cells, and neutrophils in the lumen of alveoli, bronchi, and bronchioles. Sheep 3 also showed type II pneumocytes with enlarged and hyperchromatic nuclei, sometimes binucleated with evident nucleoli, and, in some regions, the pneumocytes were desquamated to the alveolar lumen forming small syncytia and mild multifocal hyperplasia in the bronchial epithelium. The anti-cytokeratin IHC evaluation showed marked diffuse intracytoplasmic staining in hyperplastic type II pneumocytes in the bronchiolar epithelium of the three evaluated sheep. The liver of the three sheep had mild multifocal centrilobular necrosis. It seems to be the second report of spontaneous poisoning by T. micrantha in sheep developing lung lesions described in Brazil and the first in the State of Santa Catarina.
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spelling Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, BrazilToxic plantpneumotoxicosisTrema micranthasheepinterstitial pneumoniahepatotoxicBrazilABSTRACT: Poisoning by Trema micrantha commonly causes hepatocellular necrosis in cattle, sheep, and goats and edema and cerebral hemorrhage in horses. This plant can cause toxic pneumopathy in sheep, and there is only one report of the natural form and one of the experimental form in the State of Rio Grande do Sul. This study aimed to report an outbreak of the respiratory form of natural poisoning by T. micrantha in sheep. Six sheep developed clinical respiratory signs after consumption of the plant and four of them died and two recovered after treatment with dexamethasone. The sheep presented tachypnea, noisy breathing, edema of the face, eyelids, and vulva, and subcutaneous emphysema on the face and neck. Necropsy (Sheep 2, 3, and 4) showed uncollapsed, heavy, diffuse red lungs with evident costal impressions and a moderate amount of serosanguineous fluid flowed at section. The liver had a moderate diffuse evident lobular pattern. The histopathology of the lungs of the three necropsied sheep showed congestion and edema with the formation of hyaline membranes within accentuated diffuse alveoli, in addition to thickening of the alveolar septa due to mild to moderate diffuse type II pneumocyte hyperplasia and also mild to moderate diffuse infiltrate of macrophages, lymphocytes, plasma cells, and neutrophils in the lumen of alveoli, bronchi, and bronchioles. Sheep 3 also showed type II pneumocytes with enlarged and hyperchromatic nuclei, sometimes binucleated with evident nucleoli, and, in some regions, the pneumocytes were desquamated to the alveolar lumen forming small syncytia and mild multifocal hyperplasia in the bronchial epithelium. The anti-cytokeratin IHC evaluation showed marked diffuse intracytoplasmic staining in hyperplastic type II pneumocytes in the bronchiolar epithelium of the three evaluated sheep. The liver of the three sheep had mild multifocal centrilobular necrosis. It seems to be the second report of spontaneous poisoning by T. micrantha in sheep developing lung lesions described in Brazil and the first in the State of Santa Catarina.Colégio Brasileiro de Patologia Animal - CBPA2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2022000100234Pesquisa Veterinária Brasileira v.42 2022reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/1678-5150-pvb-7128info:eu-repo/semantics/openAccessQuevedo,Lucas S.Cristo,Thierry G.Cunha,Anna L.O.Hemckmeier,DeiseMarian,LucasMedeiros,Amanda L.V.Pandolfo,Gustavo W.Casagrande,Renata A.eng2022-09-20T00:00:00Zoai:scielo:S0100-736X2022000100234Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2022-09-20T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false
dc.title.none.fl_str_mv Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, Brazil
title Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, Brazil
spellingShingle Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, Brazil
Quevedo,Lucas S.
Toxic plant
pneumotoxicosis
Trema micrantha
sheep
interstitial pneumonia
hepatotoxic
Brazil
title_short Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, Brazil
title_full Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, Brazil
title_fullStr Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, Brazil
title_full_unstemmed Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, Brazil
title_sort Toxic pneumopathy by Trema micrantha in sheep in the State of Santa Catarina, Brazil
author Quevedo,Lucas S.
author_facet Quevedo,Lucas S.
Cristo,Thierry G.
Cunha,Anna L.O.
Hemckmeier,Deise
Marian,Lucas
Medeiros,Amanda L.V.
Pandolfo,Gustavo W.
Casagrande,Renata A.
author_role author
author2 Cristo,Thierry G.
Cunha,Anna L.O.
Hemckmeier,Deise
Marian,Lucas
Medeiros,Amanda L.V.
Pandolfo,Gustavo W.
Casagrande,Renata A.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Quevedo,Lucas S.
Cristo,Thierry G.
Cunha,Anna L.O.
Hemckmeier,Deise
Marian,Lucas
Medeiros,Amanda L.V.
Pandolfo,Gustavo W.
Casagrande,Renata A.
dc.subject.por.fl_str_mv Toxic plant
pneumotoxicosis
Trema micrantha
sheep
interstitial pneumonia
hepatotoxic
Brazil
topic Toxic plant
pneumotoxicosis
Trema micrantha
sheep
interstitial pneumonia
hepatotoxic
Brazil
description ABSTRACT: Poisoning by Trema micrantha commonly causes hepatocellular necrosis in cattle, sheep, and goats and edema and cerebral hemorrhage in horses. This plant can cause toxic pneumopathy in sheep, and there is only one report of the natural form and one of the experimental form in the State of Rio Grande do Sul. This study aimed to report an outbreak of the respiratory form of natural poisoning by T. micrantha in sheep. Six sheep developed clinical respiratory signs after consumption of the plant and four of them died and two recovered after treatment with dexamethasone. The sheep presented tachypnea, noisy breathing, edema of the face, eyelids, and vulva, and subcutaneous emphysema on the face and neck. Necropsy (Sheep 2, 3, and 4) showed uncollapsed, heavy, diffuse red lungs with evident costal impressions and a moderate amount of serosanguineous fluid flowed at section. The liver had a moderate diffuse evident lobular pattern. The histopathology of the lungs of the three necropsied sheep showed congestion and edema with the formation of hyaline membranes within accentuated diffuse alveoli, in addition to thickening of the alveolar septa due to mild to moderate diffuse type II pneumocyte hyperplasia and also mild to moderate diffuse infiltrate of macrophages, lymphocytes, plasma cells, and neutrophils in the lumen of alveoli, bronchi, and bronchioles. Sheep 3 also showed type II pneumocytes with enlarged and hyperchromatic nuclei, sometimes binucleated with evident nucleoli, and, in some regions, the pneumocytes were desquamated to the alveolar lumen forming small syncytia and mild multifocal hyperplasia in the bronchial epithelium. The anti-cytokeratin IHC evaluation showed marked diffuse intracytoplasmic staining in hyperplastic type II pneumocytes in the bronchiolar epithelium of the three evaluated sheep. The liver of the three sheep had mild multifocal centrilobular necrosis. It seems to be the second report of spontaneous poisoning by T. micrantha in sheep developing lung lesions described in Brazil and the first in the State of Santa Catarina.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2022000100234
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2022000100234
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-5150-pvb-7128
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA
publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA
dc.source.none.fl_str_mv Pesquisa Veterinária Brasileira v.42 2022
reponame:Pesquisa Veterinária Brasileira (Online)
instname:Colégio Brasileiro de Patologia Animal (CBPA)
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reponame_str Pesquisa Veterinária Brasileira (Online)
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