Long term persistence of coronavirus SARS-CoV-2 infection

Detalhes bibliográficos
Autor(a) principal: Pinho,João Renato Rebello
Data de Publicação: 2021
Outros Autores: Oliveira,Ketti Gleyzer de, Sitnik,Roberta, Maluf,Maira Marranghello, Rodrigues,Pedro Henrique Sebe, Santana,Rúbia Anita Ferraz, Welter,Eliane Rosseto, Irony,Ophir
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Einstein (São Paulo)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100504
Resumo: ABSTRACT During the COVID-19 pandemic, a case of a long-term persistence of SARS-CoV-2 infection (from March 26 to May 20, 2020) was identified at a private hospital in São Paulo, SP, Brazil. The long-term positivity for SARS-CoV-2 in reverse transcriptase polymerase chain reaction tests of a patient diagnosed with COVID-19 suggests, at least part of patients who recovered, may still carry and transmit the SARS-CoV-2 virus. This fact emphasizes the importance of having at least two negative reverse transcriptase polymerase chain reaction test results for SARS-CoV-2. Serological assays were not particularly helpful in the case described, since the patient had very low antibodies titers at the end of the follow-up period. Low viral loads may not be detected by current molecular methods, leading to wrong conclusions regarding viral clearance.
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spelling Long term persistence of coronavirus SARS-CoV-2 infectionCOVID-19SARS-CoV-2Infecções CoronavírusCoronavírusABSTRACT During the COVID-19 pandemic, a case of a long-term persistence of SARS-CoV-2 infection (from March 26 to May 20, 2020) was identified at a private hospital in São Paulo, SP, Brazil. The long-term positivity for SARS-CoV-2 in reverse transcriptase polymerase chain reaction tests of a patient diagnosed with COVID-19 suggests, at least part of patients who recovered, may still carry and transmit the SARS-CoV-2 virus. This fact emphasizes the importance of having at least two negative reverse transcriptase polymerase chain reaction test results for SARS-CoV-2. Serological assays were not particularly helpful in the case described, since the patient had very low antibodies titers at the end of the follow-up period. Low viral loads may not be detected by current molecular methods, leading to wrong conclusions regarding viral clearance.Instituto Israelita de Ensino e Pesquisa Albert Einstein2021-01-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100504einstein (São Paulo) v.19 2021reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.31744/einstein_journal/2021rc6369info:eu-repo/semantics/openAccessPinho,João Renato RebelloOliveira,Ketti Gleyzer deSitnik,RobertaMaluf,Maira MarranghelloRodrigues,Pedro Henrique SebeSantana,Rúbia Anita FerrazWelter,Eliane RossetoIrony,Ophireng2021-12-07T00:00:00Zoai:scielo:S1679-45082021000100504Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2021-12-07T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false
dc.title.none.fl_str_mv Long term persistence of coronavirus SARS-CoV-2 infection
title Long term persistence of coronavirus SARS-CoV-2 infection
spellingShingle Long term persistence of coronavirus SARS-CoV-2 infection
Pinho,João Renato Rebello
COVID-19
SARS-CoV-2
Infecções Coronavírus
Coronavírus
title_short Long term persistence of coronavirus SARS-CoV-2 infection
title_full Long term persistence of coronavirus SARS-CoV-2 infection
title_fullStr Long term persistence of coronavirus SARS-CoV-2 infection
title_full_unstemmed Long term persistence of coronavirus SARS-CoV-2 infection
title_sort Long term persistence of coronavirus SARS-CoV-2 infection
author Pinho,João Renato Rebello
author_facet Pinho,João Renato Rebello
Oliveira,Ketti Gleyzer de
Sitnik,Roberta
Maluf,Maira Marranghello
Rodrigues,Pedro Henrique Sebe
Santana,Rúbia Anita Ferraz
Welter,Eliane Rosseto
Irony,Ophir
author_role author
author2 Oliveira,Ketti Gleyzer de
Sitnik,Roberta
Maluf,Maira Marranghello
Rodrigues,Pedro Henrique Sebe
Santana,Rúbia Anita Ferraz
Welter,Eliane Rosseto
Irony,Ophir
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pinho,João Renato Rebello
Oliveira,Ketti Gleyzer de
Sitnik,Roberta
Maluf,Maira Marranghello
Rodrigues,Pedro Henrique Sebe
Santana,Rúbia Anita Ferraz
Welter,Eliane Rosseto
Irony,Ophir
dc.subject.por.fl_str_mv COVID-19
SARS-CoV-2
Infecções Coronavírus
Coronavírus
topic COVID-19
SARS-CoV-2
Infecções Coronavírus
Coronavírus
description ABSTRACT During the COVID-19 pandemic, a case of a long-term persistence of SARS-CoV-2 infection (from March 26 to May 20, 2020) was identified at a private hospital in São Paulo, SP, Brazil. The long-term positivity for SARS-CoV-2 in reverse transcriptase polymerase chain reaction tests of a patient diagnosed with COVID-19 suggests, at least part of patients who recovered, may still carry and transmit the SARS-CoV-2 virus. This fact emphasizes the importance of having at least two negative reverse transcriptase polymerase chain reaction test results for SARS-CoV-2. Serological assays were not particularly helpful in the case described, since the patient had very low antibodies titers at the end of the follow-up period. Low viral loads may not be detected by current molecular methods, leading to wrong conclusions regarding viral clearance.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100504
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100504
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.31744/einstein_journal/2021rc6369
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
dc.source.none.fl_str_mv einstein (São Paulo) v.19 2021
reponame:Einstein (São Paulo)
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instacron:IIEPAE
instname_str Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
instacron_str IIEPAE
institution IIEPAE
reponame_str Einstein (São Paulo)
collection Einstein (São Paulo)
repository.name.fl_str_mv Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)
repository.mail.fl_str_mv ||revista@einstein.br
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