Alteration of vascular permeability in burn injury

Detalhes bibliográficos
Autor(a) principal: Huang,Qiaobing
Data de Publicação: 2014
Outros Autores: Zhao,Ming, Zhao,Keseng
Tipo de documento: Artigo
Idioma: eng
Título da fonte: MedicalExpress (São Paulo. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292014000200062
Resumo: Massive burn trauma is characterized by hypovolemic shock induced by the loss of plasma from vessels. The elevation of vascular permeability and the ultimate formation of tissue edema are important events during the development of severe burn injury. The underlying mechanisms involved in the increased permeability include the activation of multiple endothelial signaling pathways and the changes of endothelial structure and functions. This review summarizes some of our recent discoveries in endothelial mechanisms during burninduced vascular hyper-permeability. The emphasis is put on tight junction, adherens junction, and the contraction of endothelial cells. The effects of several protein kinases, including Rho kinase, protein kinase C, and MAPKs are also stressed.
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spelling Alteration of vascular permeability in burn injuryMicrocirculationPermeabilityBurnMassive burn trauma is characterized by hypovolemic shock induced by the loss of plasma from vessels. The elevation of vascular permeability and the ultimate formation of tissue edema are important events during the development of severe burn injury. The underlying mechanisms involved in the increased permeability include the activation of multiple endothelial signaling pathways and the changes of endothelial structure and functions. This review summarizes some of our recent discoveries in endothelial mechanisms during burninduced vascular hyper-permeability. The emphasis is put on tight junction, adherens junction, and the contraction of endothelial cells. The effects of several protein kinases, including Rho kinase, protein kinase C, and MAPKs are also stressed.Mavera Edições Técnicas e Científicas Ltda2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292014000200062MedicalExpress v.1 n.2 2014reponame:MedicalExpress (São Paulo. Online)instname:Mavera Edições Científicas e Técnicas Ltda-MEinstacron:METC10.5935/MedicalExpress.2014.02.03info:eu-repo/semantics/openAccessHuang,QiaobingZhao,MingZhao,Kesengeng2016-06-07T00:00:00Zoai:scielo:S2358-04292014000200062Revistahttp://www.medicalexpress.net.brhttps://old.scielo.br/oai/scielo-oai.php||medicalexpress@me.net.br2358-04292318-8111opendoar:2016-06-07T00:00MedicalExpress (São Paulo. Online) - Mavera Edições Científicas e Técnicas Ltda-MEfalse
dc.title.none.fl_str_mv Alteration of vascular permeability in burn injury
title Alteration of vascular permeability in burn injury
spellingShingle Alteration of vascular permeability in burn injury
Huang,Qiaobing
Microcirculation
Permeability
Burn
title_short Alteration of vascular permeability in burn injury
title_full Alteration of vascular permeability in burn injury
title_fullStr Alteration of vascular permeability in burn injury
title_full_unstemmed Alteration of vascular permeability in burn injury
title_sort Alteration of vascular permeability in burn injury
author Huang,Qiaobing
author_facet Huang,Qiaobing
Zhao,Ming
Zhao,Keseng
author_role author
author2 Zhao,Ming
Zhao,Keseng
author2_role author
author
dc.contributor.author.fl_str_mv Huang,Qiaobing
Zhao,Ming
Zhao,Keseng
dc.subject.por.fl_str_mv Microcirculation
Permeability
Burn
topic Microcirculation
Permeability
Burn
description Massive burn trauma is characterized by hypovolemic shock induced by the loss of plasma from vessels. The elevation of vascular permeability and the ultimate formation of tissue edema are important events during the development of severe burn injury. The underlying mechanisms involved in the increased permeability include the activation of multiple endothelial signaling pathways and the changes of endothelial structure and functions. This review summarizes some of our recent discoveries in endothelial mechanisms during burninduced vascular hyper-permeability. The emphasis is put on tight junction, adherens junction, and the contraction of endothelial cells. The effects of several protein kinases, including Rho kinase, protein kinase C, and MAPKs are also stressed.
publishDate 2014
dc.date.none.fl_str_mv 2014-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292014000200062
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292014000200062
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/MedicalExpress.2014.02.03
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Mavera Edições Técnicas e Científicas Ltda
publisher.none.fl_str_mv Mavera Edições Técnicas e Científicas Ltda
dc.source.none.fl_str_mv MedicalExpress v.1 n.2 2014
reponame:MedicalExpress (São Paulo. Online)
instname:Mavera Edições Científicas e Técnicas Ltda-ME
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reponame_str MedicalExpress (São Paulo. Online)
collection MedicalExpress (São Paulo. Online)
repository.name.fl_str_mv MedicalExpress (São Paulo. Online) - Mavera Edições Científicas e Técnicas Ltda-ME
repository.mail.fl_str_mv ||medicalexpress@me.net.br
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