Efeito do azeite de oliva extravirgem e da dieta tradicional brasileira sobre parâmetros da sarcopenia em obesos graves: ensaio clínico randomizado e análise de fatores associados

Detalhes bibliográficos
Autor(a) principal: Souza, Jacqueline Danesio de
Data de Publicação: 2017
Tipo de documento: Tese
Idioma: por
Título da fonte: Repositório Institucional da UFG
Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/8730
Resumo: The study is part of a randomized, parallel clinical trial entitled "Effect of nutritional intervention and olive oil in severely obesity (DieTBra Trial)." The original articles seek to investigate sarcopenia in severe obese adults in terms of prevalence, factors associated with its diagnosis and the effectiveness of extra virgin olive oil and the traditional Brazilian diet as a dietary intervention. A total of 111 severe obese individuals (body mass index [BMI] ≥ 35.0 kg/m²) participated in the clinical trial, with a follow-up of 12 weeks and three intervention groups: Olive oil = extra virgin olive oil (52 mL/day); DieTBra = traditional Brazilian diet; DieTBra + Olive Oil = DieTBra + extra virgin olive oil (52 mL/day). Appendicular skeletal muscle mass (MMEA), measured in the total form (kg), adjusted by squared height (appendicular skeletal muscle mass index [IMMEA]) and by BMI (MMEA/BMI), strength of manual (FPM) and BMI adjusted (FPM/BMI), and walking speed. The prevalence calculation considered the cutoff points proposed in the literature and the calculation of -2 standard deviation (SD) of the mean value of the parameters of muscle mass evaluated in the study population. The ANOVA test was applied to evaluate the difference between the means of the parameters of second to the age group. The prevalence according to cutoff points proposed in the literature varied from 2.88% for IMMEA, 6.73% for total MMEA and 62.50% according to MMEA/BMI. When adopting - 2 SD below the mean of the study population, the prevalence was 2.88% for total MMEA and 3.85% for IMMEA and MMEA/BMI. Although no statistically significant difference (p > 0.05) was found between the means of the parameters according to the age group, prevalence values higher than those previously demonstrated in the age group ≥ 40 years were observed. In the second article, the explanatory variables considered were age, lifestyle, health conditions, food consumption and biochemical tests. Those with p value < 0.20 in simple linear regression were included in multiple linear regression. Among the factors inversely associated with IMMEA are serum levels of tetraiodothyronine (T4) and smoking. MMEA/BMI was inversely associated with age, serum T4 levels and presence of diabetes. MMEA also remained inversely associated with serum T4 levels and diabetes. The reduction of FPM and FPM/BMI were associated with advancing age and presence of hypercholesterolemia. Already the low speed of march was associated with the presence of diabetes and hypothyroidism. The primary endpoint considered in the third article was the IMMEA and the secondary ones were: FPM, gait speed, MMEA/IMC, total MMEA, total body fat and percentage. In the endpoints and covariates analyzed, the delta was also calculated, which is the difference between the value of the end of follow-up and the baseline. Covariance analysis (ANCOVA) was performed to analyze the effect of covariates delta weight, delta physical activity, delta time of sedentary lifestyle, sex and age, on the outcomes. A significance level of 5% was adopted. After performing the ANCOVA, the covariates of the delta weight adjusted the following outcomes in the DieTBra intervention group: reduction of delta total body fat (p = 0.016), increase in delta walking speed (p = 0.042) and delta FPM (p = 0.044 ). And also for reduction of delta body fat in the DieTBra + Olive oil group (p = 0.004). When adjusted for the delta time of sedentary lifestyle, total body fat presented a significant reduction in the DieTBra + Olive oil group (p = 0.001). The prevalence of sarcopenia differed as different assessments were used for muscle mass, evidencing the need to standardize the criteria and cutoff points used in its classification. The factors associated with the evaluation parameters, evidenced the importance of the creation of clinical measures and public health aimed at the prevention of sarcopenia. The positive effects of DieTBra and DieTBra + Olive oil on the parameters of sarcopenia and adiposity, reveal the importance of the adequate evaluation, diagnosis and treatment of sarcopenia in adults with severe obesity.
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spelling Silveira, Erika Aparecida dahttp://lattes.cnpq.br/3801865783333828Silveira, Erika Aparecida daPagotto, ValériaPeixoto, Maria do Rosário GondimRotta, Rejane Faria RibeiroVitorino, Priscila Valverde de Oliveirahttp://lattes.cnpq.br/4526727208396858Souza, Jacqueline Danesio de2018-07-23T12:09:45Z2017-06-09SOUZA, Jacqueline Danesio de. Efeito do azeite de oliva extravirgem e da dieta tradicional brasileira sobre parâmetros da sarcopenia em obesos graves: ensaio clínico randomizado e análise de fatores associados. 2017. 158 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2017.http://repositorio.bc.ufg.br/tede/handle/tede/8730The study is part of a randomized, parallel clinical trial entitled "Effect of nutritional intervention and olive oil in severely obesity (DieTBra Trial)." The original articles seek to investigate sarcopenia in severe obese adults in terms of prevalence, factors associated with its diagnosis and the effectiveness of extra virgin olive oil and the traditional Brazilian diet as a dietary intervention. A total of 111 severe obese individuals (body mass index [BMI] ≥ 35.0 kg/m²) participated in the clinical trial, with a follow-up of 12 weeks and three intervention groups: Olive oil = extra virgin olive oil (52 mL/day); DieTBra = traditional Brazilian diet; DieTBra + Olive Oil = DieTBra + extra virgin olive oil (52 mL/day). Appendicular skeletal muscle mass (MMEA), measured in the total form (kg), adjusted by squared height (appendicular skeletal muscle mass index [IMMEA]) and by BMI (MMEA/BMI), strength of manual (FPM) and BMI adjusted (FPM/BMI), and walking speed. The prevalence calculation considered the cutoff points proposed in the literature and the calculation of -2 standard deviation (SD) of the mean value of the parameters of muscle mass evaluated in the study population. The ANOVA test was applied to evaluate the difference between the means of the parameters of second to the age group. The prevalence according to cutoff points proposed in the literature varied from 2.88% for IMMEA, 6.73% for total MMEA and 62.50% according to MMEA/BMI. When adopting - 2 SD below the mean of the study population, the prevalence was 2.88% for total MMEA and 3.85% for IMMEA and MMEA/BMI. Although no statistically significant difference (p > 0.05) was found between the means of the parameters according to the age group, prevalence values higher than those previously demonstrated in the age group ≥ 40 years were observed. In the second article, the explanatory variables considered were age, lifestyle, health conditions, food consumption and biochemical tests. Those with p value < 0.20 in simple linear regression were included in multiple linear regression. Among the factors inversely associated with IMMEA are serum levels of tetraiodothyronine (T4) and smoking. MMEA/BMI was inversely associated with age, serum T4 levels and presence of diabetes. MMEA also remained inversely associated with serum T4 levels and diabetes. The reduction of FPM and FPM/BMI were associated with advancing age and presence of hypercholesterolemia. Already the low speed of march was associated with the presence of diabetes and hypothyroidism. The primary endpoint considered in the third article was the IMMEA and the secondary ones were: FPM, gait speed, MMEA/IMC, total MMEA, total body fat and percentage. In the endpoints and covariates analyzed, the delta was also calculated, which is the difference between the value of the end of follow-up and the baseline. Covariance analysis (ANCOVA) was performed to analyze the effect of covariates delta weight, delta physical activity, delta time of sedentary lifestyle, sex and age, on the outcomes. A significance level of 5% was adopted. After performing the ANCOVA, the covariates of the delta weight adjusted the following outcomes in the DieTBra intervention group: reduction of delta total body fat (p = 0.016), increase in delta walking speed (p = 0.042) and delta FPM (p = 0.044 ). And also for reduction of delta body fat in the DieTBra + Olive oil group (p = 0.004). When adjusted for the delta time of sedentary lifestyle, total body fat presented a significant reduction in the DieTBra + Olive oil group (p = 0.001). The prevalence of sarcopenia differed as different assessments were used for muscle mass, evidencing the need to standardize the criteria and cutoff points used in its classification. The factors associated with the evaluation parameters, evidenced the importance of the creation of clinical measures and public health aimed at the prevention of sarcopenia. The positive effects of DieTBra and DieTBra + Olive oil on the parameters of sarcopenia and adiposity, reveal the importance of the adequate evaluation, diagnosis and treatment of sarcopenia in adults with severe obesity.O estudo está inserido no ensaio clínico, randomizado e paralelo, intitulado “Effect of nutritional intervention and olive oil in severely obesity (DieTBra Trial)”. Os artigos originais buscam investigar a sarcopenia em adultos obesos graves em termos de prevalência, fatores associados ao seu diagnóstico e a efetividade do azeite de oliva extravirgem e da dieta tradicional brasileira como intervenção dietética. Participaram do ensaio clínico 111 obesos graves (índice de massa corporal [IMC] ≥ 35,0 Kg/m²), com seguimento de 12 semanas e três grupos de intervenção: Azeite = azeite de oliva extravirgem (52 mL/dia); DieTBra = dieta tradicional brasileira; DieTBra + Azeite = DieTBra + azeite de oliva extravirgem (52 mL/dia). Foram considerados como parâmetros de avaliação da sarcopenia: massa muscular esquelética apendicular (MMEA), avaliada na forma total (kg), ajustada pela altura ao quadrado (índice de massa muscular esquelética apendicular [IMMEA]) e pelo IMC (MMEA/IMC), força de preensão manual (FPM) máxima e ajustada pelo IMC (FPM/IMC), e velocidade de marcha. O cálculo da prevalência considerou os pontos de corte propostos na literatura e o cálculo de -2 desvio padrão (DP) do valor médio dos parâmetros de massa muscular avaliados na população do estudo. O teste ANOVA foi aplicado para avaliar a diferença entre as médias dos parâmetros de segundo a faixa etária. A prevalência segundo pontos de corte propostos pela literatura variou de 2,88% por IMMEA, 6,73% pela MMEA total e 62,50% segundo MMEA/IMC. Ao adotar - 2 DP abaixo da média da população de estudo, a prevalência foi de 2,88% pela MMEA total e de 3,85% por IMMEA e MMEA/IMC. Embora não tenha sido estabelecida diferença estatística significante (p > 0,05) entre as médias dos parâmetros segundo a faixa etária, foi observado valores de prevalência superiores aos anteriormente demonstrados na faixa etária ≥ 40 anos. No segundo artigo, as variáveis explanatórias consideradas foram idade, estilo de vida, condições de saúde, consumo alimentar e exames bioquímicos. Aquelas com valor p < 0,20 na regressão linear simples foram incluídas na regressão linear múltipla. Dentre os fatores inversamente associados ao IMMEA está níveis séricos de tetraiodotironina (T4) e ser fumante. MMEA/IMC foi inversamente associado a idade, níveis séricos de T4 e presença de diabetes. A MMEA também se manteve inversamente associada a níveis sérico de T4 e diabetes. A redução da FPM e FPM/IMC foram associadas ao avançar da idade e presença de hipercolesterolemia. Já a baixa velocidade de marcha esteve associada com a presença de diabetes e hipotireoidismo. O desfecho primário considerado no terceiro artigo foi o IMMEA e os secundários foram: FPM, velocidade de marcha, MMEA/IMC, MMEA total, gordura corporal total e percentual. Nos desfechos e nas covariáveis analisadas calculou-se também o delta, que é a diferença entre o valor do final do seguimento e a linha de base. Foi realizada análise de covariância (ANCOVA) para analisar o efeito das covariáveis delta peso, delta atividade física, delta tempo de sedentarismo, sexo e idade, sobre os desfechos. Adotou-se nível de significância de 5%. Após realização da ANCOVA, a covariável delta peso ajustou os seguintes desfechos no grupo de intervenção DieTBra: redução do delta gordura corporal total (p = 0,016), aumento do delta velocidade de marcha (p = 0,042) e do delta FPM (p = 0,044). E ainda para redução do delta gordura corporal no grupo DieTBra + Azeite (p = 0,004). Quando ajustada pelo delta tempo de sedentarismo, a gordura corporal total apresentou redução significativa no grupo DieTBra + Azeite (p = 0,001). A prevalência de sarcopenia diferiu à medida que se empregou diferentes avaliações para massa muscular, evidenciando a necessidade de padronização dos critérios e pontos de corte empregados na sua classificação. Os fatores associados aos parâmetros de avaliação, evidenciaram a importância da criação de medidas clínicas e saúde pública direcionadas a prevenção da sarcopenia. Os efeitos positivos da DieTBra e DieTBra + Azeite sobre os parâmetros da sarcopenia e adiposidade, revelam a importância da adequada avaliação, diagnóstico e tratamento da sarcopenia em adultos com obesidade grave.Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2018-07-20T21:04:52Z No. of bitstreams: 2 Tese - Jacqueline Danesio de Souza - 2017.pdf: 1896817 bytes, checksum: 8b8d4091000aa37121f775268ad356c0 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2018-07-23T12:09:45Z (GMT) No. of bitstreams: 2 Tese - Jacqueline Danesio de Souza - 2017.pdf: 1896817 bytes, checksum: 8b8d4091000aa37121f775268ad356c0 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2018-07-23T12:09:45Z (GMT). No. of bitstreams: 2 Tese - Jacqueline Danesio de Souza - 2017.pdf: 1896817 bytes, checksum: 8b8d4091000aa37121f775268ad356c0 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-06-09Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências da Saúde (FM)UFGBrasilFaculdade de Medicina - FM (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessComposição corporalMassa muscular esqueléticaForça muscularVelocidade de caminhadaAzeite de olivaAlimentação saudávelBody compositionSkeletal muscle massMuscle strengthWalking speedOlive oilHealthy eatingCIENCIAS DA SAUDEEfeito do azeite de oliva extravirgem e da dieta tradicional brasileira sobre parâmetros da sarcopenia em obesos graves: ensaio clínico randomizado e análise de fatores associadosEffect of olive oil extravirgem and traditional brazilian diet on parameters of sarcopenia in severely obeses: randomized clinical testing and analysis of associated factorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis-1006864312617745310600600600600154577247595048633887654494148233069292075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.eng.fl_str_mv Efeito do azeite de oliva extravirgem e da dieta tradicional brasileira sobre parâmetros da sarcopenia em obesos graves: ensaio clínico randomizado e análise de fatores associados
dc.title.alternative.eng.fl_str_mv Effect of olive oil extravirgem and traditional brazilian diet on parameters of sarcopenia in severely obeses: randomized clinical testing and analysis of associated factors
title Efeito do azeite de oliva extravirgem e da dieta tradicional brasileira sobre parâmetros da sarcopenia em obesos graves: ensaio clínico randomizado e análise de fatores associados
spellingShingle Efeito do azeite de oliva extravirgem e da dieta tradicional brasileira sobre parâmetros da sarcopenia em obesos graves: ensaio clínico randomizado e análise de fatores associados
Souza, Jacqueline Danesio de
Composição corporal
Massa muscular esquelética
Força muscular
Velocidade de caminhada
Azeite de oliva
Alimentação saudável
Body composition
Skeletal muscle mass
Muscle strength
Walking speed
Olive oil
Healthy eating
CIENCIAS DA SAUDE
title_short Efeito do azeite de oliva extravirgem e da dieta tradicional brasileira sobre parâmetros da sarcopenia em obesos graves: ensaio clínico randomizado e análise de fatores associados
title_full Efeito do azeite de oliva extravirgem e da dieta tradicional brasileira sobre parâmetros da sarcopenia em obesos graves: ensaio clínico randomizado e análise de fatores associados
title_fullStr Efeito do azeite de oliva extravirgem e da dieta tradicional brasileira sobre parâmetros da sarcopenia em obesos graves: ensaio clínico randomizado e análise de fatores associados
title_full_unstemmed Efeito do azeite de oliva extravirgem e da dieta tradicional brasileira sobre parâmetros da sarcopenia em obesos graves: ensaio clínico randomizado e análise de fatores associados
title_sort Efeito do azeite de oliva extravirgem e da dieta tradicional brasileira sobre parâmetros da sarcopenia em obesos graves: ensaio clínico randomizado e análise de fatores associados
author Souza, Jacqueline Danesio de
author_facet Souza, Jacqueline Danesio de
author_role author
dc.contributor.advisor1.fl_str_mv Silveira, Erika Aparecida da
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3801865783333828
dc.contributor.referee1.fl_str_mv Silveira, Erika Aparecida da
dc.contributor.referee2.fl_str_mv Pagotto, Valéria
dc.contributor.referee3.fl_str_mv Peixoto, Maria do Rosário Gondim
dc.contributor.referee4.fl_str_mv Rotta, Rejane Faria Ribeiro
dc.contributor.referee5.fl_str_mv Vitorino, Priscila Valverde de Oliveira
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/4526727208396858
dc.contributor.author.fl_str_mv Souza, Jacqueline Danesio de
contributor_str_mv Silveira, Erika Aparecida da
Silveira, Erika Aparecida da
Pagotto, Valéria
Peixoto, Maria do Rosário Gondim
Rotta, Rejane Faria Ribeiro
Vitorino, Priscila Valverde de Oliveira
dc.subject.por.fl_str_mv Composição corporal
Massa muscular esquelética
Força muscular
Velocidade de caminhada
Azeite de oliva
Alimentação saudável
topic Composição corporal
Massa muscular esquelética
Força muscular
Velocidade de caminhada
Azeite de oliva
Alimentação saudável
Body composition
Skeletal muscle mass
Muscle strength
Walking speed
Olive oil
Healthy eating
CIENCIAS DA SAUDE
dc.subject.eng.fl_str_mv Body composition
Skeletal muscle mass
Muscle strength
Walking speed
Olive oil
Healthy eating
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE
description The study is part of a randomized, parallel clinical trial entitled "Effect of nutritional intervention and olive oil in severely obesity (DieTBra Trial)." The original articles seek to investigate sarcopenia in severe obese adults in terms of prevalence, factors associated with its diagnosis and the effectiveness of extra virgin olive oil and the traditional Brazilian diet as a dietary intervention. A total of 111 severe obese individuals (body mass index [BMI] ≥ 35.0 kg/m²) participated in the clinical trial, with a follow-up of 12 weeks and three intervention groups: Olive oil = extra virgin olive oil (52 mL/day); DieTBra = traditional Brazilian diet; DieTBra + Olive Oil = DieTBra + extra virgin olive oil (52 mL/day). Appendicular skeletal muscle mass (MMEA), measured in the total form (kg), adjusted by squared height (appendicular skeletal muscle mass index [IMMEA]) and by BMI (MMEA/BMI), strength of manual (FPM) and BMI adjusted (FPM/BMI), and walking speed. The prevalence calculation considered the cutoff points proposed in the literature and the calculation of -2 standard deviation (SD) of the mean value of the parameters of muscle mass evaluated in the study population. The ANOVA test was applied to evaluate the difference between the means of the parameters of second to the age group. The prevalence according to cutoff points proposed in the literature varied from 2.88% for IMMEA, 6.73% for total MMEA and 62.50% according to MMEA/BMI. When adopting - 2 SD below the mean of the study population, the prevalence was 2.88% for total MMEA and 3.85% for IMMEA and MMEA/BMI. Although no statistically significant difference (p > 0.05) was found between the means of the parameters according to the age group, prevalence values higher than those previously demonstrated in the age group ≥ 40 years were observed. In the second article, the explanatory variables considered were age, lifestyle, health conditions, food consumption and biochemical tests. Those with p value < 0.20 in simple linear regression were included in multiple linear regression. Among the factors inversely associated with IMMEA are serum levels of tetraiodothyronine (T4) and smoking. MMEA/BMI was inversely associated with age, serum T4 levels and presence of diabetes. MMEA also remained inversely associated with serum T4 levels and diabetes. The reduction of FPM and FPM/BMI were associated with advancing age and presence of hypercholesterolemia. Already the low speed of march was associated with the presence of diabetes and hypothyroidism. The primary endpoint considered in the third article was the IMMEA and the secondary ones were: FPM, gait speed, MMEA/IMC, total MMEA, total body fat and percentage. In the endpoints and covariates analyzed, the delta was also calculated, which is the difference between the value of the end of follow-up and the baseline. Covariance analysis (ANCOVA) was performed to analyze the effect of covariates delta weight, delta physical activity, delta time of sedentary lifestyle, sex and age, on the outcomes. A significance level of 5% was adopted. After performing the ANCOVA, the covariates of the delta weight adjusted the following outcomes in the DieTBra intervention group: reduction of delta total body fat (p = 0.016), increase in delta walking speed (p = 0.042) and delta FPM (p = 0.044 ). And also for reduction of delta body fat in the DieTBra + Olive oil group (p = 0.004). When adjusted for the delta time of sedentary lifestyle, total body fat presented a significant reduction in the DieTBra + Olive oil group (p = 0.001). The prevalence of sarcopenia differed as different assessments were used for muscle mass, evidencing the need to standardize the criteria and cutoff points used in its classification. The factors associated with the evaluation parameters, evidenced the importance of the creation of clinical measures and public health aimed at the prevention of sarcopenia. The positive effects of DieTBra and DieTBra + Olive oil on the parameters of sarcopenia and adiposity, reveal the importance of the adequate evaluation, diagnosis and treatment of sarcopenia in adults with severe obesity.
publishDate 2017
dc.date.issued.fl_str_mv 2017-06-09
dc.date.accessioned.fl_str_mv 2018-07-23T12:09:45Z
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dc.identifier.citation.fl_str_mv SOUZA, Jacqueline Danesio de. Efeito do azeite de oliva extravirgem e da dieta tradicional brasileira sobre parâmetros da sarcopenia em obesos graves: ensaio clínico randomizado e análise de fatores associados. 2017. 158 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2017.
dc.identifier.uri.fl_str_mv http://repositorio.bc.ufg.br/tede/handle/tede/8730
identifier_str_mv SOUZA, Jacqueline Danesio de. Efeito do azeite de oliva extravirgem e da dieta tradicional brasileira sobre parâmetros da sarcopenia em obesos graves: ensaio clínico randomizado e análise de fatores associados. 2017. 158 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2017.
url http://repositorio.bc.ufg.br/tede/handle/tede/8730
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language por
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dc.relation.cnpq.fl_str_mv 8765449414823306929
dc.relation.sponsorship.fl_str_mv 2075167498588264571
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
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dc.publisher.none.fl_str_mv Universidade Federal de Goiás
dc.publisher.program.fl_str_mv Programa de Pós-graduação em Ciências da Saúde (FM)
dc.publisher.initials.fl_str_mv UFG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Faculdade de Medicina - FM (RG)
publisher.none.fl_str_mv Universidade Federal de Goiás
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