Análise da relação entre vitiligo e síndrome metabólica
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/5838 |
Resumo: | Vitiligo is an acquired, depigmenting disorder. The etiology is unknown, but mostly autoimmune, associated with high levels of pro-inflammatory cytokines. These cytokines would stimulate atherosclerosis and develop metabolic syndrome. The aim of this study was to evaluate the relationship between vitiligo and metabolic syndrome. This is a transversal study, with 96 patients (47 with and 49 without vitiligo) treated at Hospital Universitário de Santa Maria RS, from March 2013 to January 2014. The vitiligo patients were selected by clinical diagnosis and the criteria of extension and time of disease were evaluated. The diagnostic criteria for metabolic syndrome were assessed, following IDF: total cholesterol, high-density lipoprotein-cholesterol (HDL-c), triglycerides, waist circumference and blood pressure. We evaluated the insulin resistance through the homeostasis model assessment-insulin resistance (HOMA-IR). The MS prevalence between the groups does not show significant difference (36,2% vs. 38,3%, p=1,000). Waist circumference was different between groups (95,5 vs. 90,5 cm). Vitiligo group showed smaller levels of HDL-c (48,2 mg/dL vs 57,7 mg/dL, p<0,001), and this difference was sustained in the sub-analysis of female patients. HOMA-IR did not show difference between groups. Metabolic syndrome was not associated with extension and evolution time of vitiligo. This study did not reveal relation between vitiligo and MS. HDL-c was smaller in vitiligo patients, and there was inverse correlation (r = -0,30, p = 0,045) between HDL-c and insulin only in vitiligo group. |
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Análise da relação entre vitiligo e síndrome metabólicaAnalysis of the relation between vitiligo and metabolic syndromeVitiligoSíndrome metabólicaResistência insulínicaPrevalênciaDermatologiaVitiligoMetabolic syndromeInsulin resistancePrevalenceDermatologyCNPQ::CIENCIAS DA SAUDEVitiligo is an acquired, depigmenting disorder. The etiology is unknown, but mostly autoimmune, associated with high levels of pro-inflammatory cytokines. These cytokines would stimulate atherosclerosis and develop metabolic syndrome. The aim of this study was to evaluate the relationship between vitiligo and metabolic syndrome. This is a transversal study, with 96 patients (47 with and 49 without vitiligo) treated at Hospital Universitário de Santa Maria RS, from March 2013 to January 2014. The vitiligo patients were selected by clinical diagnosis and the criteria of extension and time of disease were evaluated. The diagnostic criteria for metabolic syndrome were assessed, following IDF: total cholesterol, high-density lipoprotein-cholesterol (HDL-c), triglycerides, waist circumference and blood pressure. We evaluated the insulin resistance through the homeostasis model assessment-insulin resistance (HOMA-IR). The MS prevalence between the groups does not show significant difference (36,2% vs. 38,3%, p=1,000). Waist circumference was different between groups (95,5 vs. 90,5 cm). Vitiligo group showed smaller levels of HDL-c (48,2 mg/dL vs 57,7 mg/dL, p<0,001), and this difference was sustained in the sub-analysis of female patients. HOMA-IR did not show difference between groups. Metabolic syndrome was not associated with extension and evolution time of vitiligo. This study did not reveal relation between vitiligo and MS. HDL-c was smaller in vitiligo patients, and there was inverse correlation (r = -0,30, p = 0,045) between HDL-c and insulin only in vitiligo group.O vitiligo é uma desordem adquirida da pigmentação. Sua etiologia é desconhecida, principalmente autoimune, associada com a elevação de citocinas pró-inflamatórias. As citocinas estimulariam a aterogênese, criando um estado de síndrome metabólica. O objetivo deste estudo é analisar a relação entre vitiligo e síndrome metabólica. Estudo transversal que avaliou 96 pacientes (47 com vitiligo e 49 sem vitiligo), atendidos no Hospital Universitário de Santa Maria RS, no período de março/2013 a janeiro/2014. Os pacientes com vitiligo foram selecionados por diagnóstico clínico, avaliados pela extensão da doença na pele e pelo tempo de evolução. Foram avaliados os critérios diagnósticos de síndrome metabólica (SM): dosagem sérica de colesterol total, HDL-colesterol, triglicerídeos, aferição de circunferência abdominal (CA) e da pressão arterial. A resistência insulínica (RI) foi avaliada pelo cálculo do HOMA-IR. A prevalência da SM entre os pacientes com vitiligo e sem vitiligo não mostrou diferença significativa (36,2% vs. 38,3%, p = 1,00). A CA diferiu entre os grupos, sendo maior no grupo com vitiligo (95,5 cm vs. 90,5 cm, p = 0,046). Os níveis de HDL-c foram menores no grupo com vitiligo (48,2 mg/dL vs 57,7 mg/dL, p = 0,002) , mantendo-se significativos na subanálise dos pacientes do sexo feminino (p = 0,012). O HOMA-IR também não apresentou diferença entre os grupos (2,6±1,8 vs. 2,0±1,1, p=0,285). Não houve associação de SM com tempo de evolução e nem com a extensão de acometimento do vitiligo. Não foi encontrada relação entre vitiligo e SM, entretanto, o HDL-colesterol foi mais baixo e a CA maior nos pacientes com vitiligo, e houve correlação inversa (r = - 0,31 , p = 0,045) entre valores de HDL-colesterol e insulina apenas no grupo com vitiligo.Universidade Federal de Santa MariaBRMedicinaUFSMPrograma de Pós-Graduação em Ciências da SaúdeBeck, Maristela de Oliveirahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4791123H6Grando, Elisa2015-03-272015-03-272014-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfGRANDO, Elisa. ANALYSIS OF THE RELATION BETWEEN VITILIGO AND METABOLIC SYNDROME. 2014. 57 f. Dissertação (Mestrado em Medicina) - Universidade Federal de Santa Maria, Santa Maria, 2014.http://repositorio.ufsm.br/handle/1/5838porinfo:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2022-07-18T15:37:01Zoai:repositorio.ufsm.br:1/5838Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2022-07-18T15:37:01Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Análise da relação entre vitiligo e síndrome metabólica Analysis of the relation between vitiligo and metabolic syndrome |
title |
Análise da relação entre vitiligo e síndrome metabólica |
spellingShingle |
Análise da relação entre vitiligo e síndrome metabólica Grando, Elisa Vitiligo Síndrome metabólica Resistência insulínica Prevalência Dermatologia Vitiligo Metabolic syndrome Insulin resistance Prevalence Dermatology CNPQ::CIENCIAS DA SAUDE |
title_short |
Análise da relação entre vitiligo e síndrome metabólica |
title_full |
Análise da relação entre vitiligo e síndrome metabólica |
title_fullStr |
Análise da relação entre vitiligo e síndrome metabólica |
title_full_unstemmed |
Análise da relação entre vitiligo e síndrome metabólica |
title_sort |
Análise da relação entre vitiligo e síndrome metabólica |
author |
Grando, Elisa |
author_facet |
Grando, Elisa |
author_role |
author |
dc.contributor.none.fl_str_mv |
Beck, Maristela de Oliveira http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4791123H6 |
dc.contributor.author.fl_str_mv |
Grando, Elisa |
dc.subject.por.fl_str_mv |
Vitiligo Síndrome metabólica Resistência insulínica Prevalência Dermatologia Vitiligo Metabolic syndrome Insulin resistance Prevalence Dermatology CNPQ::CIENCIAS DA SAUDE |
topic |
Vitiligo Síndrome metabólica Resistência insulínica Prevalência Dermatologia Vitiligo Metabolic syndrome Insulin resistance Prevalence Dermatology CNPQ::CIENCIAS DA SAUDE |
description |
Vitiligo is an acquired, depigmenting disorder. The etiology is unknown, but mostly autoimmune, associated with high levels of pro-inflammatory cytokines. These cytokines would stimulate atherosclerosis and develop metabolic syndrome. The aim of this study was to evaluate the relationship between vitiligo and metabolic syndrome. This is a transversal study, with 96 patients (47 with and 49 without vitiligo) treated at Hospital Universitário de Santa Maria RS, from March 2013 to January 2014. The vitiligo patients were selected by clinical diagnosis and the criteria of extension and time of disease were evaluated. The diagnostic criteria for metabolic syndrome were assessed, following IDF: total cholesterol, high-density lipoprotein-cholesterol (HDL-c), triglycerides, waist circumference and blood pressure. We evaluated the insulin resistance through the homeostasis model assessment-insulin resistance (HOMA-IR). The MS prevalence between the groups does not show significant difference (36,2% vs. 38,3%, p=1,000). Waist circumference was different between groups (95,5 vs. 90,5 cm). Vitiligo group showed smaller levels of HDL-c (48,2 mg/dL vs 57,7 mg/dL, p<0,001), and this difference was sustained in the sub-analysis of female patients. HOMA-IR did not show difference between groups. Metabolic syndrome was not associated with extension and evolution time of vitiligo. This study did not reveal relation between vitiligo and MS. HDL-c was smaller in vitiligo patients, and there was inverse correlation (r = -0,30, p = 0,045) between HDL-c and insulin only in vitiligo group. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08-01 2015-03-27 2015-03-27 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
GRANDO, Elisa. ANALYSIS OF THE RELATION BETWEEN VITILIGO AND METABOLIC SYNDROME. 2014. 57 f. Dissertação (Mestrado em Medicina) - Universidade Federal de Santa Maria, Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/5838 |
identifier_str_mv |
GRANDO, Elisa. ANALYSIS OF THE RELATION BETWEEN VITILIGO AND METABOLIC SYNDROME. 2014. 57 f. Dissertação (Mestrado em Medicina) - Universidade Federal de Santa Maria, Santa Maria, 2014. |
url |
http://repositorio.ufsm.br/handle/1/5838 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Medicina UFSM Programa de Pós-Graduação em Ciências da Saúde |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Medicina UFSM Programa de Pós-Graduação em Ciências da Saúde |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
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