Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/5863 |
Resumo: | Introduction: Helicobater pylori interferes with vitamin C homeostasis and low levels of vitamin C may be a risk factor for H. pylori infection. Objective: to investigate the vitamin C serum and gastric juice levels of patients infected and non-infected by H. pylori. Additionally assess the association of vitamin C levels with H.pylori status, gastric pH and histological changes of gastric mucosa of dyspeptic patients with normal upper GI endoscopy. Methods: We studied 42 dyspeptic patients undergoing upper GI endoscopy had biopsies for diagnosis of H. pylori infection and gastric mucosa changes. We also collected 5 ml of blood (for dosage of serum vitamin C) and 10 ml of gastric juice. We measure pH of gastric juice. We used high-performance liquid chromatography to assess Vitamin C in serum and gastric juice. Results: The average age was 52 years (SD±11.8), 84.4% female, overweight BMI median 27,7) with adequate dietary intake of vitamin C. Twenty four (53.3%) patients had H. pylori infection. The median serum vitamin C levels in infected and non-infected was 3.9 and 3.4 μg (p = 0.59). The median gastric juice levels of vitamin C was 9,8 μg in infected and 18.4 μg in non-infected (p = 0.03). The histology showed normal mucosa in eight 8 (20%), chronic non-atrophic gastritis in 23 (55%) and chronic atrophic gastritis in 11 (26%) patients. There was no significant association of histology with Vitamin C serum levels (p = 0.26) or gastric (p = 0.29). Conclusion: Vitamin C serum levels were within the normal range, and most patients had adequate food ingestion of vitamin C. Serum levels of vitamin C were similar in individuals infected and non-infected while vitamin C levels in the gastric juice of patients infected were reduced compared with patients non-infected. Serum levels of vitamin C were higher in the gastric juice than in serum, regardless the patients were infected or not. |
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Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pyloriVitamin C in the serum and gastric juice of dyspeptic patients with and without Helicobacter pylori infectionHelicobacter pyloriConsumo alimentarVitamina CH pyloriFood intakeVitamin CCNPQ::CIENCIAS DA SAUDEIntroduction: Helicobater pylori interferes with vitamin C homeostasis and low levels of vitamin C may be a risk factor for H. pylori infection. Objective: to investigate the vitamin C serum and gastric juice levels of patients infected and non-infected by H. pylori. Additionally assess the association of vitamin C levels with H.pylori status, gastric pH and histological changes of gastric mucosa of dyspeptic patients with normal upper GI endoscopy. Methods: We studied 42 dyspeptic patients undergoing upper GI endoscopy had biopsies for diagnosis of H. pylori infection and gastric mucosa changes. We also collected 5 ml of blood (for dosage of serum vitamin C) and 10 ml of gastric juice. We measure pH of gastric juice. We used high-performance liquid chromatography to assess Vitamin C in serum and gastric juice. Results: The average age was 52 years (SD±11.8), 84.4% female, overweight BMI median 27,7) with adequate dietary intake of vitamin C. Twenty four (53.3%) patients had H. pylori infection. The median serum vitamin C levels in infected and non-infected was 3.9 and 3.4 μg (p = 0.59). The median gastric juice levels of vitamin C was 9,8 μg in infected and 18.4 μg in non-infected (p = 0.03). The histology showed normal mucosa in eight 8 (20%), chronic non-atrophic gastritis in 23 (55%) and chronic atrophic gastritis in 11 (26%) patients. There was no significant association of histology with Vitamin C serum levels (p = 0.26) or gastric (p = 0.29). Conclusion: Vitamin C serum levels were within the normal range, and most patients had adequate food ingestion of vitamin C. Serum levels of vitamin C were similar in individuals infected and non-infected while vitamin C levels in the gastric juice of patients infected were reduced compared with patients non-infected. Serum levels of vitamin C were higher in the gastric juice than in serum, regardless the patients were infected or not.Introdução: A infecção por Helicobater pylori influencia na homeostase da vitamina C e níveis baixos da mesma podem determinar risco para a infecção. Objetivo: Investigar os níveis de vitamina C no soro e suco gástrico de pacientes infectados e não infectados por H. pylori e estudar sua associação com a infecção, com o pH gástrico e com as alterações anatomopatológicas da mucosa gástrica de pacientes dispépticos funcionais. Métodos: Foram estudados 42 pacientes dispépticos submetidos a endoscopia digestiva alta e biópsia para diagnóstico da infecção por H. pylori e de alterações anatomopatológicas da mucosa gástrica, classificadas de acordo com o Sistema Sidney. Aspirado suco gástrico com mensuração do pH e coleta de 5 ml de sangue para dosagem de vitamina C no soro. A dosagem da Vitamina C no soro e no suco gástrico foi realizada por cromatografia líquida de alta performance. Resultados: A idade média foi de 52 anos (DP±11,8), 84,4% do sexo feminino, com sobrepeso (IMC mediana=27,7), com adequada ingestão alimentar de vitamina C. Vinte e quatro (53,3%) pacientes apresentavam infecção por H. pylori. A mediana dos níveis de vitamina C no soro dos infectados foi 3,9 μg/ml e nos não infectados 3,4 μg/ml (p=0,59). A mediana dos níveis de vitamina C no suco gástrico foi 9,8 μg/ml nos infectados e 18,4 μg/ml nos não infectados (p=0,03). A histologia demonstrou mucosa normal em 8 (20%), gastrite crônica não atrófica em 23 (55%) e gastrite crônica atrófica em 11 (26%) pacientes, sem associação significativa com os níveis séricos (p=0,26) ou gástricos (p=0,29) da vitamina C. Conclusões: O nível sérico da vitamina C nos pacientes estudados esteve dentro dos valores de referência normais e o consumo de vitamina C foi adequado na maioria. Os níveis séricos da vitamina C foram semelhantes em indivíduos infectados e não infectados enquanto os níveis de vitamina C apresentaram-se reduzidos no suco gástrico dos pacientes infectados por H. pylori em comparação com os não infectados. Os níveis séricos de vitamina C foram mais altos no suco gástrico do que no soro, independentemente da condição de infectado ou não.Universidade Federal de Santa MariaBRMedicinaUFSMPrograma de Pós-Graduação em Ciências da SaúdeFagundes, Renato Borgeshttp://lattes.cnpq.br/5255286815018611Beck, Sandra Trevisanhttp://lattes.cnpq.br/4435727183593265Comim, Fabio Vasconcelloshttp://lattes.cnpq.br/5119233991388822Silva, Carina Siqueira Martelli da2016-11-182016-11-182015-06-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfSILVA, Carina Siqueira Martelli da. Vitamin C in the serum and gastric juice of dyspeptic patients with and without Helicobacter pylori infection. 2015. 45 f. Dissertação (Mestrado em Medicina) - Universidade Federal de Santa Maria, Santa Maria, 2015.http://repositorio.ufsm.br/handle/1/5863porinfo:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2022-04-12T13:35:44Zoai:repositorio.ufsm.br:1/5863Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2022-04-12T13:35:44Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori Vitamin C in the serum and gastric juice of dyspeptic patients with and without Helicobacter pylori infection |
title |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori |
spellingShingle |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori Silva, Carina Siqueira Martelli da Helicobacter pylori Consumo alimentar Vitamina C H pylori Food intake Vitamin C CNPQ::CIENCIAS DA SAUDE |
title_short |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori |
title_full |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori |
title_fullStr |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori |
title_full_unstemmed |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori |
title_sort |
Vitamina C no soro e suco gástrico de pacientes dispépticos com e sem infecção por Helicobacter pylori |
author |
Silva, Carina Siqueira Martelli da |
author_facet |
Silva, Carina Siqueira Martelli da |
author_role |
author |
dc.contributor.none.fl_str_mv |
Fagundes, Renato Borges http://lattes.cnpq.br/5255286815018611 Beck, Sandra Trevisan http://lattes.cnpq.br/4435727183593265 Comim, Fabio Vasconcellos http://lattes.cnpq.br/5119233991388822 |
dc.contributor.author.fl_str_mv |
Silva, Carina Siqueira Martelli da |
dc.subject.por.fl_str_mv |
Helicobacter pylori Consumo alimentar Vitamina C H pylori Food intake Vitamin C CNPQ::CIENCIAS DA SAUDE |
topic |
Helicobacter pylori Consumo alimentar Vitamina C H pylori Food intake Vitamin C CNPQ::CIENCIAS DA SAUDE |
description |
Introduction: Helicobater pylori interferes with vitamin C homeostasis and low levels of vitamin C may be a risk factor for H. pylori infection. Objective: to investigate the vitamin C serum and gastric juice levels of patients infected and non-infected by H. pylori. Additionally assess the association of vitamin C levels with H.pylori status, gastric pH and histological changes of gastric mucosa of dyspeptic patients with normal upper GI endoscopy. Methods: We studied 42 dyspeptic patients undergoing upper GI endoscopy had biopsies for diagnosis of H. pylori infection and gastric mucosa changes. We also collected 5 ml of blood (for dosage of serum vitamin C) and 10 ml of gastric juice. We measure pH of gastric juice. We used high-performance liquid chromatography to assess Vitamin C in serum and gastric juice. Results: The average age was 52 years (SD±11.8), 84.4% female, overweight BMI median 27,7) with adequate dietary intake of vitamin C. Twenty four (53.3%) patients had H. pylori infection. The median serum vitamin C levels in infected and non-infected was 3.9 and 3.4 μg (p = 0.59). The median gastric juice levels of vitamin C was 9,8 μg in infected and 18.4 μg in non-infected (p = 0.03). The histology showed normal mucosa in eight 8 (20%), chronic non-atrophic gastritis in 23 (55%) and chronic atrophic gastritis in 11 (26%) patients. There was no significant association of histology with Vitamin C serum levels (p = 0.26) or gastric (p = 0.29). Conclusion: Vitamin C serum levels were within the normal range, and most patients had adequate food ingestion of vitamin C. Serum levels of vitamin C were similar in individuals infected and non-infected while vitamin C levels in the gastric juice of patients infected were reduced compared with patients non-infected. Serum levels of vitamin C were higher in the gastric juice than in serum, regardless the patients were infected or not. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06-10 2016-11-18 2016-11-18 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
SILVA, Carina Siqueira Martelli da. Vitamin C in the serum and gastric juice of dyspeptic patients with and without Helicobacter pylori infection. 2015. 45 f. Dissertação (Mestrado em Medicina) - Universidade Federal de Santa Maria, Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/5863 |
identifier_str_mv |
SILVA, Carina Siqueira Martelli da. Vitamin C in the serum and gastric juice of dyspeptic patients with and without Helicobacter pylori infection. 2015. 45 f. Dissertação (Mestrado em Medicina) - Universidade Federal de Santa Maria, Santa Maria, 2015. |
url |
http://repositorio.ufsm.br/handle/1/5863 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Medicina UFSM Programa de Pós-Graduação em Ciências da Saúde |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Medicina UFSM Programa de Pós-Graduação em Ciências da Saúde |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
_version_ |
1805922145048461312 |