Incidência de displasia broncopulmonar em recém nascidos de muito baixo peso ao nascer e fatores associados
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/17209 |
Resumo: | Bronchopulmonary dysplasia (BPD) is a neonatal lung disease with a significant impact on morbidity and mortality in preterm infants. Although several risk factors have been identified, BDP results from a complex interaction between the development of immature lungs and multiple pre and postnatal exposures. Interventions to reduce exposure have not reduced risk, suggesting a multifactorial etiology. This study aimed to determine the incidence of Bronchopulmonary Dysplasia and possible risk factors for the disease in preterm newborns with very low birth weight (<1500 g) hospitalized in the Neonatal Intensive Care Unit. An observational, retrospective cohort study involving 107 very low birth weight preterm infants admitted to a neonatal unit over a three-year period. Univariate and multiple logistic regression analysis was performed to determine the association of some variables (independent) with the occurrence of BPD (dependent variable). A significance level of p <0.05 was accepted. The incidence of BPD in the studied population was 39.3% (n = 42) and inversely proportional to gestational age at birth (p <0.05). In preterm infants (<28 weeks) it was 60.71%; in the very preterm infants (28-31.6) it was 48.89% and in the moderates (32-33.6) it was of 10.34%. No newborn with GA greater than 33.6 weeks developed BPD. Among the risk factors were the need for resuscitation in the delivery room, patent ductus arteriosus and early and late sepsis, which remained associated with multiple regression analysis. Early sepsis occurred in 80.95% (34) of the children who had BPD, and in 53.13% (34) of those who did not have BPD (p = 0.003). Likewise, late sepsis was prevalent in children with BPD, when compared to the others (90.48% X 50%, respectively, p <0.001). The reduction in the rate of infection seems to be an essential factor in reducing the prevalence of this disease. |
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Incidência de displasia broncopulmonar em recém nascidos de muito baixo peso ao nascer e fatores associadosIncidence of bronchopulmonary displasia in new births of very low weight at birth and associated factorsDisplasia broncopulmonarPrematuridadeOxigênioBronchopulmonary dysplasiaPrematurityOxygenCNPQ::CIENCIAS DA SAUDE::MEDICINABronchopulmonary dysplasia (BPD) is a neonatal lung disease with a significant impact on morbidity and mortality in preterm infants. Although several risk factors have been identified, BDP results from a complex interaction between the development of immature lungs and multiple pre and postnatal exposures. Interventions to reduce exposure have not reduced risk, suggesting a multifactorial etiology. This study aimed to determine the incidence of Bronchopulmonary Dysplasia and possible risk factors for the disease in preterm newborns with very low birth weight (<1500 g) hospitalized in the Neonatal Intensive Care Unit. An observational, retrospective cohort study involving 107 very low birth weight preterm infants admitted to a neonatal unit over a three-year period. Univariate and multiple logistic regression analysis was performed to determine the association of some variables (independent) with the occurrence of BPD (dependent variable). A significance level of p <0.05 was accepted. The incidence of BPD in the studied population was 39.3% (n = 42) and inversely proportional to gestational age at birth (p <0.05). In preterm infants (<28 weeks) it was 60.71%; in the very preterm infants (28-31.6) it was 48.89% and in the moderates (32-33.6) it was of 10.34%. No newborn with GA greater than 33.6 weeks developed BPD. Among the risk factors were the need for resuscitation in the delivery room, patent ductus arteriosus and early and late sepsis, which remained associated with multiple regression analysis. Early sepsis occurred in 80.95% (34) of the children who had BPD, and in 53.13% (34) of those who did not have BPD (p = 0.003). Likewise, late sepsis was prevalent in children with BPD, when compared to the others (90.48% X 50%, respectively, p <0.001). The reduction in the rate of infection seems to be an essential factor in reducing the prevalence of this disease.Displasia Broncopulmonar (DBP) é uma doença pulmonar do período neonatal com importante impacto na morbi/mortalidade em recém-nascidos prematuros. Embora vários fatores de risco têm sido identificados, a BDP resulta de uma complexa interação entre o desenvolvimento de pulmões imaturos e múltiplas exposições pré e pós-natais. Intervenções para reduzir a exposição não tem diminuído o risco, sugerindo uma etiologia multifatorial. Este estudo teve como objetivo determinar a incidência de Displasia Broncopulmonar, e os possíveis fatores de risco para a doença em recém-nascidos pré termo de muito baixo peso ao nascer (<1500 gramas) internados em Unidade de Tratamento Intensivo Neonatal. Estudo observacional analítico, do tipo coorte retrospectiva, que envolveu 107 recémnascidos pré-termo de muito baixo peso ao nascer internados em unidade neonatal em um período de três anos. Análise de regressão logística univariada e múltipla foi realizada para determinar a associação de algumas variáveis (independentes) com a ocorrência de DBP (variável dependente). Foi aceito um nível de significância de p< 0,05. A incidência de DBP na população estudada foi de 39,3% (n = 42), sendo inversamente proporcional a idade gestacional ao nascer (p<0,05). Nos prematuros extremos (<28 semanas de IG) foi de 60,71%, nos muito prematuros (28-31,6 semanas de IG) foi de 48,89% e nos moderados (32-33,6 semanas de IG) foi de 10,34%. Nenhum RN com IG maior que 33,6 semanas desenvolveu DBP. Dentre os fatores de risco destacaram-se a necessidade de reanimação em sala de parto, a persistência do canal arterial e a sepse precoce e tardia, tendo esta permanecido associada na análise de regressão múltipla. Sepse precoce ocorreu em 80,95% (34) das crianças que tiveram DBP, e em 53,13% (34) das que não tiveram (p=0,003). Da mesma forma, sepse tardia foi prevalente nas crianças com DBP, quando comparadas as demais (90,48% X 50%, respectivamente; p<0,001). A redução na taxa de infecção parece ser fator essencial para a diminuição da prevalência desta doença.Universidade Federal de Santa MariaBrasilMedicinaUFSMPrograma de Pós-Graduação em Ciências da SaúdeCentro de Ciências da SaúdeWeinmann, Angela Regina Macielhttp://lattes.cnpq.br/9151119377173425Haeffner, Leris Salete Bonfantihttp://lattes.cnpq.br/4056008693346464Henn, Roselihttp://lattes.cnpq.br/9216370645875137Tomé, Cindiamar2019-06-28T22:10:44Z2019-06-28T22:10:44Z2018-10-27info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://repositorio.ufsm.br/handle/1/17209porAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2019-06-29T06:00:39Zoai:repositorio.ufsm.br:1/17209Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2019-06-29T06:00:39Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Incidência de displasia broncopulmonar em recém nascidos de muito baixo peso ao nascer e fatores associados Incidence of bronchopulmonary displasia in new births of very low weight at birth and associated factors |
title |
Incidência de displasia broncopulmonar em recém nascidos de muito baixo peso ao nascer e fatores associados |
spellingShingle |
Incidência de displasia broncopulmonar em recém nascidos de muito baixo peso ao nascer e fatores associados Tomé, Cindiamar Displasia broncopulmonar Prematuridade Oxigênio Bronchopulmonary dysplasia Prematurity Oxygen CNPQ::CIENCIAS DA SAUDE::MEDICINA |
title_short |
Incidência de displasia broncopulmonar em recém nascidos de muito baixo peso ao nascer e fatores associados |
title_full |
Incidência de displasia broncopulmonar em recém nascidos de muito baixo peso ao nascer e fatores associados |
title_fullStr |
Incidência de displasia broncopulmonar em recém nascidos de muito baixo peso ao nascer e fatores associados |
title_full_unstemmed |
Incidência de displasia broncopulmonar em recém nascidos de muito baixo peso ao nascer e fatores associados |
title_sort |
Incidência de displasia broncopulmonar em recém nascidos de muito baixo peso ao nascer e fatores associados |
author |
Tomé, Cindiamar |
author_facet |
Tomé, Cindiamar |
author_role |
author |
dc.contributor.none.fl_str_mv |
Weinmann, Angela Regina Maciel http://lattes.cnpq.br/9151119377173425 Haeffner, Leris Salete Bonfanti http://lattes.cnpq.br/4056008693346464 Henn, Roseli http://lattes.cnpq.br/9216370645875137 |
dc.contributor.author.fl_str_mv |
Tomé, Cindiamar |
dc.subject.por.fl_str_mv |
Displasia broncopulmonar Prematuridade Oxigênio Bronchopulmonary dysplasia Prematurity Oxygen CNPQ::CIENCIAS DA SAUDE::MEDICINA |
topic |
Displasia broncopulmonar Prematuridade Oxigênio Bronchopulmonary dysplasia Prematurity Oxygen CNPQ::CIENCIAS DA SAUDE::MEDICINA |
description |
Bronchopulmonary dysplasia (BPD) is a neonatal lung disease with a significant impact on morbidity and mortality in preterm infants. Although several risk factors have been identified, BDP results from a complex interaction between the development of immature lungs and multiple pre and postnatal exposures. Interventions to reduce exposure have not reduced risk, suggesting a multifactorial etiology. This study aimed to determine the incidence of Bronchopulmonary Dysplasia and possible risk factors for the disease in preterm newborns with very low birth weight (<1500 g) hospitalized in the Neonatal Intensive Care Unit. An observational, retrospective cohort study involving 107 very low birth weight preterm infants admitted to a neonatal unit over a three-year period. Univariate and multiple logistic regression analysis was performed to determine the association of some variables (independent) with the occurrence of BPD (dependent variable). A significance level of p <0.05 was accepted. The incidence of BPD in the studied population was 39.3% (n = 42) and inversely proportional to gestational age at birth (p <0.05). In preterm infants (<28 weeks) it was 60.71%; in the very preterm infants (28-31.6) it was 48.89% and in the moderates (32-33.6) it was of 10.34%. No newborn with GA greater than 33.6 weeks developed BPD. Among the risk factors were the need for resuscitation in the delivery room, patent ductus arteriosus and early and late sepsis, which remained associated with multiple regression analysis. Early sepsis occurred in 80.95% (34) of the children who had BPD, and in 53.13% (34) of those who did not have BPD (p = 0.003). Likewise, late sepsis was prevalent in children with BPD, when compared to the others (90.48% X 50%, respectively, p <0.001). The reduction in the rate of infection seems to be an essential factor in reducing the prevalence of this disease. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-27 2019-06-28T22:10:44Z 2019-06-28T22:10:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/17209 |
url |
http://repositorio.ufsm.br/handle/1/17209 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Brasil Medicina UFSM Programa de Pós-Graduação em Ciências da Saúde Centro de Ciências da Saúde |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Brasil Medicina UFSM Programa de Pós-Graduação em Ciências da Saúde Centro de Ciências da Saúde |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
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1805922059926110208 |