Effect of the celexoxib in microscopic changes of the esophageal mucosal of rats induced by esofagojejunostomy
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Colégio Brasileiro de Cirurgiões |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912014000300193 |
Resumo: | OBJECTIVE: To evaluate the protective effect of celecoxib in the esophageal mucosa in rats undergoing esofagojejunostomy.METHODS: Sixty male Wistar rats from the vivarium of the University of Health Sciences of Alagoas were used for the experiment. The animals were divided into four groups: Group I, 15 rats undergoing esofagojejunostomy with the use of celecoxib postoperatively; Group II, 15 rats undergoing esofagojejunostomy without the use of celecoxib; Group III, 15 rats undergoing celiotomy with bowel manipulation; and Group IV, 15 rats without surgery and using celecoxib. The observation period was 90 days. After the death of the animals, the distal segment of the esophagus was resected and sent for microscopic analysis.RESULTS: esofagojejunostomy caused macroscopic and microscopic esophagitis. Esophagitis was equal in both groups I and II. In groups III and IV esophageal lesions were not developed.CONCLUSIONS: celecoxib had neither protective nor inducing effect on esophagitis, but had a protective effect on dysplasia of the animals of group I. |
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Effect of the celexoxib in microscopic changes of the esophageal mucosal of rats induced by esofagojejunostomyEsophagitis, pepticEpithelium/histologyInflammationGeneral surgeryRats, WistarOBJECTIVE: To evaluate the protective effect of celecoxib in the esophageal mucosa in rats undergoing esofagojejunostomy.METHODS: Sixty male Wistar rats from the vivarium of the University of Health Sciences of Alagoas were used for the experiment. The animals were divided into four groups: Group I, 15 rats undergoing esofagojejunostomy with the use of celecoxib postoperatively; Group II, 15 rats undergoing esofagojejunostomy without the use of celecoxib; Group III, 15 rats undergoing celiotomy with bowel manipulation; and Group IV, 15 rats without surgery and using celecoxib. The observation period was 90 days. After the death of the animals, the distal segment of the esophagus was resected and sent for microscopic analysis.RESULTS: esofagojejunostomy caused macroscopic and microscopic esophagitis. Esophagitis was equal in both groups I and II. In groups III and IV esophageal lesions were not developed.CONCLUSIONS: celecoxib had neither protective nor inducing effect on esophagitis, but had a protective effect on dysplasia of the animals of group I.Colégio Brasileiro de Cirurgiões2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912014000300193Revista do Colégio Brasileiro de Cirurgiões v.41 n.3 2014reponame:Revista do Colégio Brasileiro de Cirurgiõesinstname:Colégio Brasileiro de Cirurgiões (CBC)instacron:CBC10.1590/S0100-69912014000300010info:eu-repo/semantics/openAccessLima,Austry Ferreira deLourenço,Laercio GomesMatos,DélcioRodrigues,Célio Fernando de Sousaeng2015-09-25T00:00:00Zoai:scielo:S0100-69912014000300193Revistahttp://www.scielo.br/rcbcONGhttps://old.scielo.br/oai/scielo-oai.php||revistacbc@cbc.org.br1809-45460100-6991opendoar:2015-09-25T00:00Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC)false |
dc.title.none.fl_str_mv |
Effect of the celexoxib in microscopic changes of the esophageal mucosal of rats induced by esofagojejunostomy |
title |
Effect of the celexoxib in microscopic changes of the esophageal mucosal of rats induced by esofagojejunostomy |
spellingShingle |
Effect of the celexoxib in microscopic changes of the esophageal mucosal of rats induced by esofagojejunostomy Lima,Austry Ferreira de Esophagitis, peptic Epithelium/histology Inflammation General surgery Rats, Wistar |
title_short |
Effect of the celexoxib in microscopic changes of the esophageal mucosal of rats induced by esofagojejunostomy |
title_full |
Effect of the celexoxib in microscopic changes of the esophageal mucosal of rats induced by esofagojejunostomy |
title_fullStr |
Effect of the celexoxib in microscopic changes of the esophageal mucosal of rats induced by esofagojejunostomy |
title_full_unstemmed |
Effect of the celexoxib in microscopic changes of the esophageal mucosal of rats induced by esofagojejunostomy |
title_sort |
Effect of the celexoxib in microscopic changes of the esophageal mucosal of rats induced by esofagojejunostomy |
author |
Lima,Austry Ferreira de |
author_facet |
Lima,Austry Ferreira de Lourenço,Laercio Gomes Matos,Délcio Rodrigues,Célio Fernando de Sousa |
author_role |
author |
author2 |
Lourenço,Laercio Gomes Matos,Délcio Rodrigues,Célio Fernando de Sousa |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Lima,Austry Ferreira de Lourenço,Laercio Gomes Matos,Délcio Rodrigues,Célio Fernando de Sousa |
dc.subject.por.fl_str_mv |
Esophagitis, peptic Epithelium/histology Inflammation General surgery Rats, Wistar |
topic |
Esophagitis, peptic Epithelium/histology Inflammation General surgery Rats, Wistar |
description |
OBJECTIVE: To evaluate the protective effect of celecoxib in the esophageal mucosa in rats undergoing esofagojejunostomy.METHODS: Sixty male Wistar rats from the vivarium of the University of Health Sciences of Alagoas were used for the experiment. The animals were divided into four groups: Group I, 15 rats undergoing esofagojejunostomy with the use of celecoxib postoperatively; Group II, 15 rats undergoing esofagojejunostomy without the use of celecoxib; Group III, 15 rats undergoing celiotomy with bowel manipulation; and Group IV, 15 rats without surgery and using celecoxib. The observation period was 90 days. After the death of the animals, the distal segment of the esophagus was resected and sent for microscopic analysis.RESULTS: esofagojejunostomy caused macroscopic and microscopic esophagitis. Esophagitis was equal in both groups I and II. In groups III and IV esophageal lesions were not developed.CONCLUSIONS: celecoxib had neither protective nor inducing effect on esophagitis, but had a protective effect on dysplasia of the animals of group I. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912014000300193 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912014000300193 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-69912014000300010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
dc.source.none.fl_str_mv |
Revista do Colégio Brasileiro de Cirurgiões v.41 n.3 2014 reponame:Revista do Colégio Brasileiro de Cirurgiões instname:Colégio Brasileiro de Cirurgiões (CBC) instacron:CBC |
instname_str |
Colégio Brasileiro de Cirurgiões (CBC) |
instacron_str |
CBC |
institution |
CBC |
reponame_str |
Revista do Colégio Brasileiro de Cirurgiões |
collection |
Revista do Colégio Brasileiro de Cirurgiões |
repository.name.fl_str_mv |
Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC) |
repository.mail.fl_str_mv |
||revistacbc@cbc.org.br |
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1754209212689285120 |