Mansoni schistosomiasis in experimentally undernourished mice
Main Author: | |
---|---|
Publication Date: | 1986 |
Other Authors: | , , , , |
Format: | Article |
Language: | por |
Source: | Revista de Saúde Pública |
Download full: | https://www.revistas.usp.br/rsp/article/view/23378 |
Summary: | Mansoni schistosomiasis was studied in mice fed on a low protein diet. Four groups of the Swiss breed Mus musculus were used in an experiment with two factors, each with two levels: 1-non-infected, normal diet; 2 - infected, normal diet ; 3 - non-infected, low protein diet; 4 - infected, low protein diet. The mice were killed for observation at age 90 days, after 60 days of infection, for those infected. It was found that the worms suffered the effects of malnutrition, mainly males, whose population count was cut by half, in addition to poor individual growth. The hepatic granuloma count was found to be smaller in the undernourished group; while the corresponding lesions were also generally smaller. There was a marked leukopenia in the malnourished mice, even more so in the infected mice. The severe lymphopenia and eosinopenia observed suggest that the immunologic system of the host was affected by malnutrition. Mortality rates were far larger in the infected, low protein diet group. One may then surmise that the malnourished mice offered lower resistance to the infection, their lower number of granuloma notwithstanding. |
id |
USP-23_c143a53393ac9750d8169961b56e5a8b |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/23378 |
network_acronym_str |
USP-23 |
network_name_str |
Revista de Saúde Pública |
repository_id_str |
|
spelling |
Mansoni schistosomiasis in experimentally undernourished mice Esquistossomose mansônica em camundongos experimentalmente subnutridos Esquistossomose mansônica^i1^scomplicaçDeficiência de proteínaCamundongo^i1^sparasitoloCamundongo^i1^sinfecção experimenSchistosoma mansoniSchistosomiasis mansoni^i2^scomplicatiProtein deficiencyMice^i2^sparasitolMice^i2^sexperimental infectSchistosoma mansoni Mansoni schistosomiasis was studied in mice fed on a low protein diet. Four groups of the Swiss breed Mus musculus were used in an experiment with two factors, each with two levels: 1-non-infected, normal diet; 2 - infected, normal diet ; 3 - non-infected, low protein diet; 4 - infected, low protein diet. The mice were killed for observation at age 90 days, after 60 days of infection, for those infected. It was found that the worms suffered the effects of malnutrition, mainly males, whose population count was cut by half, in addition to poor individual growth. The hepatic granuloma count was found to be smaller in the undernourished group; while the corresponding lesions were also generally smaller. There was a marked leukopenia in the malnourished mice, even more so in the infected mice. The severe lymphopenia and eosinopenia observed suggest that the immunologic system of the host was affected by malnutrition. Mortality rates were far larger in the infected, low protein diet group. One may then surmise that the malnourished mice offered lower resistance to the infection, their lower number of granuloma notwithstanding. Realizou-se estudo sobre o desenvolvimento da esquistossomose mansônica em camundongos submetidos à dieta hipoprotéica. Foram constituídos 4 grupos de Mus musculus "Swiss" da seguinte forma: 1) não infectados, normoprotéicos; 2) infectados, normoprotéicos; 3) não infectados, hipoprotéicos e 4) infectados, hipoprotéicos. Os animais foram sacrificados com 60 dias de infecção, aos 90 dias de idade. Verificou-se que os esquistossomos sofreram os efeitos da subnutrição do hospedeiro, principalmente os vermes machos, que além de terem seu desenvolvimento prejudicado, tiveram seu número reduzido aproximadamente pela metade. O número de granulomas foi menor nos roedores subnutridos e o tamanho da lesão foi reduzido. Houve acentuada leucopenia nos animais submetidos à dieta hipoprotéica, principalmente nos infectados subnutridos. A linfopenia e a eosinopenia acentuadas sugeriram que o sistema imunológico do hospedeiro foi afetado pela subnutrição. A taxa de mortalidade foi muito mais elevada nos animais infectados submetidos à dieta hipoprotéica. Concluiu-se que os camundongos subnutridos resistiram menos à infecção esquistossomótica apesar de terem apresentado menor número de lesões granulomatosas. Universidade de São Paulo. Faculdade de Saúde Pública1986-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/2337810.1590/S0034-89101986000500005Revista de Saúde Pública; Vol. 20 No. 5 (1986); 362-368 Revista de Saúde Pública; Vol. 20 Núm. 5 (1986); 362-368 Revista de Saúde Pública; v. 20 n. 5 (1986); 362-368 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/rsp/article/view/23378/25409Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessMagalhães, Luiz AugustoGuaraldo, Ana Maria A.Zanotti-Magalhães, Eliana M.Carvalho, José F. deSgarbieri, Valdomiro C.Alcântara, Francisco G. de2012-05-28T16:25:17Zoai:revistas.usp.br:article/23378Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-05-28T16:25:17Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Mansoni schistosomiasis in experimentally undernourished mice Esquistossomose mansônica em camundongos experimentalmente subnutridos |
title |
Mansoni schistosomiasis in experimentally undernourished mice |
spellingShingle |
Mansoni schistosomiasis in experimentally undernourished mice Magalhães, Luiz Augusto Esquistossomose mansônica^i1^scomplicaç Deficiência de proteína Camundongo^i1^sparasitolo Camundongo^i1^sinfecção experimen Schistosoma mansoni Schistosomiasis mansoni^i2^scomplicati Protein deficiency Mice^i2^sparasitol Mice^i2^sexperimental infect Schistosoma mansoni |
title_short |
Mansoni schistosomiasis in experimentally undernourished mice |
title_full |
Mansoni schistosomiasis in experimentally undernourished mice |
title_fullStr |
Mansoni schistosomiasis in experimentally undernourished mice |
title_full_unstemmed |
Mansoni schistosomiasis in experimentally undernourished mice |
title_sort |
Mansoni schistosomiasis in experimentally undernourished mice |
author |
Magalhães, Luiz Augusto |
author_facet |
Magalhães, Luiz Augusto Guaraldo, Ana Maria A. Zanotti-Magalhães, Eliana M. Carvalho, José F. de Sgarbieri, Valdomiro C. Alcântara, Francisco G. de |
author_role |
author |
author2 |
Guaraldo, Ana Maria A. Zanotti-Magalhães, Eliana M. Carvalho, José F. de Sgarbieri, Valdomiro C. Alcântara, Francisco G. de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Magalhães, Luiz Augusto Guaraldo, Ana Maria A. Zanotti-Magalhães, Eliana M. Carvalho, José F. de Sgarbieri, Valdomiro C. Alcântara, Francisco G. de |
dc.subject.por.fl_str_mv |
Esquistossomose mansônica^i1^scomplicaç Deficiência de proteína Camundongo^i1^sparasitolo Camundongo^i1^sinfecção experimen Schistosoma mansoni Schistosomiasis mansoni^i2^scomplicati Protein deficiency Mice^i2^sparasitol Mice^i2^sexperimental infect Schistosoma mansoni |
topic |
Esquistossomose mansônica^i1^scomplicaç Deficiência de proteína Camundongo^i1^sparasitolo Camundongo^i1^sinfecção experimen Schistosoma mansoni Schistosomiasis mansoni^i2^scomplicati Protein deficiency Mice^i2^sparasitol Mice^i2^sexperimental infect Schistosoma mansoni |
description |
Mansoni schistosomiasis was studied in mice fed on a low protein diet. Four groups of the Swiss breed Mus musculus were used in an experiment with two factors, each with two levels: 1-non-infected, normal diet; 2 - infected, normal diet ; 3 - non-infected, low protein diet; 4 - infected, low protein diet. The mice were killed for observation at age 90 days, after 60 days of infection, for those infected. It was found that the worms suffered the effects of malnutrition, mainly males, whose population count was cut by half, in addition to poor individual growth. The hepatic granuloma count was found to be smaller in the undernourished group; while the corresponding lesions were also generally smaller. There was a marked leukopenia in the malnourished mice, even more so in the infected mice. The severe lymphopenia and eosinopenia observed suggest that the immunologic system of the host was affected by malnutrition. Mortality rates were far larger in the infected, low protein diet group. One may then surmise that the malnourished mice offered lower resistance to the infection, their lower number of granuloma notwithstanding. |
publishDate |
1986 |
dc.date.none.fl_str_mv |
1986-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/23378 10.1590/S0034-89101986000500005 |
url |
https://www.revistas.usp.br/rsp/article/view/23378 |
identifier_str_mv |
10.1590/S0034-89101986000500005 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/23378/25409 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Revista de Saúde Pública info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Revista de Saúde Pública |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
dc.source.none.fl_str_mv |
Revista de Saúde Pública; Vol. 20 No. 5 (1986); 362-368 Revista de Saúde Pública; Vol. 20 Núm. 5 (1986); 362-368 Revista de Saúde Pública; v. 20 n. 5 (1986); 362-368 1518-8787 0034-8910 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
_version_ |
1800221773233389568 |