In vitro antimalarial activity of six Aspidosperma species from the state of Minas Gerais (Brazil)

Detalhes bibliográficos
Autor(a) principal: Dolabela,Maria Fâni
Data de Publicação: 2012
Outros Autores: Oliveira,Salma G., Peres,José M., Nascimento,José M.S., Póvoa,Marinete M., Oliveira,Alaide B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400005
Resumo: Ethnomedicinal informations point to some Aspidosperma species (Apocynaceae) as antimalarial plants in Brazil and have motivated the evaluation of six species which were collected in the state of Minas Gerais: A. cylindrocarpon Müll. Arg., A. parvifolium A. DC., A. olivaceum Müll. Arg., A. ramiflorum Müll. Arg., A. spruceanum Benth. ex Müll. Arg. and A. tomentosum Mart.. A total of 23 extracts of different plant parts in different solvents were assayed in vitro against chloroquine-resistant (W2) and chloroquine-sensitive (3D7) strains of Plasmodium falciparum. All the extracts were shown to be active with IC50 values in the range of 5.0 ± 0 2.8 µg/mL to 65.0 ± 4.2 µg/mL. TLC profile of the extracts revealed the presence of alkaloids in the six species assayed. These results seem to confirm the popular use of Aspidosperma species to treat human malaria in Brazil and seem point to alkaloids as the putative active compounds of the assayed species.
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spelling In vitro antimalarial activity of six Aspidosperma species from the state of Minas Gerais (Brazil)antimalarial activityPlasmodium falciparumIn vitro assaysAspidosperma spp.ApocynaceaeEthnomedicinal informations point to some Aspidosperma species (Apocynaceae) as antimalarial plants in Brazil and have motivated the evaluation of six species which were collected in the state of Minas Gerais: A. cylindrocarpon Müll. Arg., A. parvifolium A. DC., A. olivaceum Müll. Arg., A. ramiflorum Müll. Arg., A. spruceanum Benth. ex Müll. Arg. and A. tomentosum Mart.. A total of 23 extracts of different plant parts in different solvents were assayed in vitro against chloroquine-resistant (W2) and chloroquine-sensitive (3D7) strains of Plasmodium falciparum. All the extracts were shown to be active with IC50 values in the range of 5.0 ± 0 2.8 µg/mL to 65.0 ± 4.2 µg/mL. TLC profile of the extracts revealed the presence of alkaloids in the six species assayed. These results seem to confirm the popular use of Aspidosperma species to treat human malaria in Brazil and seem point to alkaloids as the putative active compounds of the assayed species.Academia Brasileira de Ciências2012-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400005Anais da Academia Brasileira de Ciências v.84 n.4 2012reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652012000400005info:eu-repo/semantics/openAccessDolabela,Maria FâniOliveira,Salma G.Peres,José M.Nascimento,José M.S.Póvoa,Marinete M.Oliveira,Alaide B.eng2012-11-29T00:00:00Zoai:scielo:S0001-37652012000400005Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2012-11-29T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv In vitro antimalarial activity of six Aspidosperma species from the state of Minas Gerais (Brazil)
title In vitro antimalarial activity of six Aspidosperma species from the state of Minas Gerais (Brazil)
spellingShingle In vitro antimalarial activity of six Aspidosperma species from the state of Minas Gerais (Brazil)
Dolabela,Maria Fâni
antimalarial activity
Plasmodium falciparum
In vitro assays
Aspidosperma spp.
Apocynaceae
title_short In vitro antimalarial activity of six Aspidosperma species from the state of Minas Gerais (Brazil)
title_full In vitro antimalarial activity of six Aspidosperma species from the state of Minas Gerais (Brazil)
title_fullStr In vitro antimalarial activity of six Aspidosperma species from the state of Minas Gerais (Brazil)
title_full_unstemmed In vitro antimalarial activity of six Aspidosperma species from the state of Minas Gerais (Brazil)
title_sort In vitro antimalarial activity of six Aspidosperma species from the state of Minas Gerais (Brazil)
author Dolabela,Maria Fâni
author_facet Dolabela,Maria Fâni
Oliveira,Salma G.
Peres,José M.
Nascimento,José M.S.
Póvoa,Marinete M.
Oliveira,Alaide B.
author_role author
author2 Oliveira,Salma G.
Peres,José M.
Nascimento,José M.S.
Póvoa,Marinete M.
Oliveira,Alaide B.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Dolabela,Maria Fâni
Oliveira,Salma G.
Peres,José M.
Nascimento,José M.S.
Póvoa,Marinete M.
Oliveira,Alaide B.
dc.subject.por.fl_str_mv antimalarial activity
Plasmodium falciparum
In vitro assays
Aspidosperma spp.
Apocynaceae
topic antimalarial activity
Plasmodium falciparum
In vitro assays
Aspidosperma spp.
Apocynaceae
description Ethnomedicinal informations point to some Aspidosperma species (Apocynaceae) as antimalarial plants in Brazil and have motivated the evaluation of six species which were collected in the state of Minas Gerais: A. cylindrocarpon Müll. Arg., A. parvifolium A. DC., A. olivaceum Müll. Arg., A. ramiflorum Müll. Arg., A. spruceanum Benth. ex Müll. Arg. and A. tomentosum Mart.. A total of 23 extracts of different plant parts in different solvents were assayed in vitro against chloroquine-resistant (W2) and chloroquine-sensitive (3D7) strains of Plasmodium falciparum. All the extracts were shown to be active with IC50 values in the range of 5.0 ± 0 2.8 µg/mL to 65.0 ± 4.2 µg/mL. TLC profile of the extracts revealed the presence of alkaloids in the six species assayed. These results seem to confirm the popular use of Aspidosperma species to treat human malaria in Brazil and seem point to alkaloids as the putative active compounds of the assayed species.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0001-37652012000400005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.84 n.4 2012
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
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institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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