Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602331 |
Resumo: | ABSTRACT Background: Children and adolescents with at-risk genotypes (AA/AT) of the rs9939609 polymorphism in FTO, a fat mass and obesity-associated gene, may exhibit different cardiometabolic profile responses than subjects with the TT genotype after an interdisciplinary intervention. Methods: The sample consisted of 36 school children from southern Brazil. We used DNA quantitation and real-time polymerase chain reaction (PCR) for polymorphism genotyping. We measured anthropometric parameters (body mass index (BMI), waist circumference, hip circumference, waist-hip ratio, body fat percentage and skinfold sum), biochemical parameters (glucose, lipid profile, ultra-sensitive C-reactive protein, uric acid, alanine aminotransferase, aspartate aminotransferase, insulin and adiponectin) and blood pressure. The 4-month intervention consisted of physical education classes, nutritional counseling, and postural and oral health counseling. Results: We observed no significant differences among the groups (AA, AT and TT) after the intervention. However, we observed improvements in three parameters (waist circumference, hip circumference and C-reactive protein) in the AT/AA genotype group and in two parameters (hip circumference and uric acid) in the TT genotype group. Conclusions: After an intervention program, carriers of at-risk genotypes for obesity (AA/AT) do not exhibit differences in biochemical parameters, blood pressure and anthropometric parameters compared with carriers of the TT genotype. |
id |
ABC-1_6dbe3666671f189acf4b70350db77af2 |
---|---|
oai_identifier_str |
oai:scielo:S0001-37652016000602331 |
network_acronym_str |
ABC-1 |
network_name_str |
Anais da Academia Brasileira de Ciências (Online) |
repository_id_str |
|
spelling |
Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an interventiongenotypeinterventionobesitychildrenphysical activityABSTRACT Background: Children and adolescents with at-risk genotypes (AA/AT) of the rs9939609 polymorphism in FTO, a fat mass and obesity-associated gene, may exhibit different cardiometabolic profile responses than subjects with the TT genotype after an interdisciplinary intervention. Methods: The sample consisted of 36 school children from southern Brazil. We used DNA quantitation and real-time polymerase chain reaction (PCR) for polymorphism genotyping. We measured anthropometric parameters (body mass index (BMI), waist circumference, hip circumference, waist-hip ratio, body fat percentage and skinfold sum), biochemical parameters (glucose, lipid profile, ultra-sensitive C-reactive protein, uric acid, alanine aminotransferase, aspartate aminotransferase, insulin and adiponectin) and blood pressure. The 4-month intervention consisted of physical education classes, nutritional counseling, and postural and oral health counseling. Results: We observed no significant differences among the groups (AA, AT and TT) after the intervention. However, we observed improvements in three parameters (waist circumference, hip circumference and C-reactive protein) in the AT/AA genotype group and in two parameters (hip circumference and uric acid) in the TT genotype group. Conclusions: After an intervention program, carriers of at-risk genotypes for obesity (AA/AT) do not exhibit differences in biochemical parameters, blood pressure and anthropometric parameters compared with carriers of the TT genotype.Academia Brasileira de Ciências2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602331Anais da Academia Brasileira de Ciências v.88 n.4 2016reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201620160114info:eu-repo/semantics/openAccessMORAES,GREICE G.REUTER,CÉZANE P.RENNER,JANE D.P.KLINGER,ELISA I.FERREIRA,MICHELE B.MELLO,ELZA D. DEVALIM,ANDRÉIA DE M.BURGOS,MIRIA S.eng2017-06-12T00:00:00Zoai:scielo:S0001-37652016000602331Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2017-06-12T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention |
title |
Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention |
spellingShingle |
Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention MORAES,GREICE G. genotype intervention obesity children physical activity |
title_short |
Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention |
title_full |
Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention |
title_fullStr |
Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention |
title_full_unstemmed |
Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention |
title_sort |
Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention |
author |
MORAES,GREICE G. |
author_facet |
MORAES,GREICE G. REUTER,CÉZANE P. RENNER,JANE D.P. KLINGER,ELISA I. FERREIRA,MICHELE B. MELLO,ELZA D. DE VALIM,ANDRÉIA DE M. BURGOS,MIRIA S. |
author_role |
author |
author2 |
REUTER,CÉZANE P. RENNER,JANE D.P. KLINGER,ELISA I. FERREIRA,MICHELE B. MELLO,ELZA D. DE VALIM,ANDRÉIA DE M. BURGOS,MIRIA S. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
MORAES,GREICE G. REUTER,CÉZANE P. RENNER,JANE D.P. KLINGER,ELISA I. FERREIRA,MICHELE B. MELLO,ELZA D. DE VALIM,ANDRÉIA DE M. BURGOS,MIRIA S. |
dc.subject.por.fl_str_mv |
genotype intervention obesity children physical activity |
topic |
genotype intervention obesity children physical activity |
description |
ABSTRACT Background: Children and adolescents with at-risk genotypes (AA/AT) of the rs9939609 polymorphism in FTO, a fat mass and obesity-associated gene, may exhibit different cardiometabolic profile responses than subjects with the TT genotype after an interdisciplinary intervention. Methods: The sample consisted of 36 school children from southern Brazil. We used DNA quantitation and real-time polymerase chain reaction (PCR) for polymorphism genotyping. We measured anthropometric parameters (body mass index (BMI), waist circumference, hip circumference, waist-hip ratio, body fat percentage and skinfold sum), biochemical parameters (glucose, lipid profile, ultra-sensitive C-reactive protein, uric acid, alanine aminotransferase, aspartate aminotransferase, insulin and adiponectin) and blood pressure. The 4-month intervention consisted of physical education classes, nutritional counseling, and postural and oral health counseling. Results: We observed no significant differences among the groups (AA, AT and TT) after the intervention. However, we observed improvements in three parameters (waist circumference, hip circumference and C-reactive protein) in the AT/AA genotype group and in two parameters (hip circumference and uric acid) in the TT genotype group. Conclusions: After an intervention program, carriers of at-risk genotypes for obesity (AA/AT) do not exhibit differences in biochemical parameters, blood pressure and anthropometric parameters compared with carriers of the TT genotype. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602331 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602331 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765201620160114 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.88 n.4 2016 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
_version_ |
1754302862459928576 |