Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal de Pediatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572016000600521 |
Resumo: | Abstract Objective: Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures for the prevention of obesity. The aim of this study was to assess the association between the FTO, AKT1, and AKTIP genes and childhood obesity and insulin resistance. Methods: This was a case-control study in which SNPs in the FTO (rs99396096), AKT1, and AKTIP genes were genotyped in groups of controls and obese/overweight children. The study included 195 obese/overweight children and 153 control subjects. Results: As expected, the obese/overweight group subjects had higher body mass index, higher fasting glucose, HOMA-IR index, total cholesterol, low-density lipoprotein, and triglycerides. However, no significant differences were observed in genes polymorphisms genotype or allele frequencies. Conclusion: The present results suggest that AKT1, FTO, and AKTIP polymorphisms were not associated with obesity/overweight in Brazilians children. Future studies on the genetics of obesity in Brazilian children and their environment interactions are needed. |
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Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesitySingle-nucleotide polymorphismsChildhood obesityFat mass and obesity associatedGeneAKT1AKTIPAbstract Objective: Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures for the prevention of obesity. The aim of this study was to assess the association between the FTO, AKT1, and AKTIP genes and childhood obesity and insulin resistance. Methods: This was a case-control study in which SNPs in the FTO (rs99396096), AKT1, and AKTIP genes were genotyped in groups of controls and obese/overweight children. The study included 195 obese/overweight children and 153 control subjects. Results: As expected, the obese/overweight group subjects had higher body mass index, higher fasting glucose, HOMA-IR index, total cholesterol, low-density lipoprotein, and triglycerides. However, no significant differences were observed in genes polymorphisms genotype or allele frequencies. Conclusion: The present results suggest that AKT1, FTO, and AKTIP polymorphisms were not associated with obesity/overweight in Brazilians children. Future studies on the genetics of obesity in Brazilian children and their environment interactions are needed.Sociedade Brasileira de Pediatria2016-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572016000600521Jornal de Pediatria v.92 n.5 2016reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2015.12.007info:eu-repo/semantics/openAccessPereira,Patrícia de AraújoAlvim-Soares Jr.,António MarcosSandrim,Valéria CristinaLanna,Carla Márcia MoreiraSouza-Costa,Débora CristineBelo,Vanessa de AlmeidaPaula,Jonas Jardim deTanus-Santos,José EduardoRomano-Silva,Marco AurélioMiranda,Débora Marques deeng2016-10-11T00:00:00Zoai:scielo:S0021-75572016000600521Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2016-10-11T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
title |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
spellingShingle |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity Pereira,Patrícia de Araújo Single-nucleotide polymorphisms Childhood obesity Fat mass and obesity associated Gene AKT1 AKTIP |
title_short |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
title_full |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
title_fullStr |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
title_full_unstemmed |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
title_sort |
Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
author |
Pereira,Patrícia de Araújo |
author_facet |
Pereira,Patrícia de Araújo Alvim-Soares Jr.,António Marcos Sandrim,Valéria Cristina Lanna,Carla Márcia Moreira Souza-Costa,Débora Cristine Belo,Vanessa de Almeida Paula,Jonas Jardim de Tanus-Santos,José Eduardo Romano-Silva,Marco Aurélio Miranda,Débora Marques de |
author_role |
author |
author2 |
Alvim-Soares Jr.,António Marcos Sandrim,Valéria Cristina Lanna,Carla Márcia Moreira Souza-Costa,Débora Cristine Belo,Vanessa de Almeida Paula,Jonas Jardim de Tanus-Santos,José Eduardo Romano-Silva,Marco Aurélio Miranda,Débora Marques de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pereira,Patrícia de Araújo Alvim-Soares Jr.,António Marcos Sandrim,Valéria Cristina Lanna,Carla Márcia Moreira Souza-Costa,Débora Cristine Belo,Vanessa de Almeida Paula,Jonas Jardim de Tanus-Santos,José Eduardo Romano-Silva,Marco Aurélio Miranda,Débora Marques de |
dc.subject.por.fl_str_mv |
Single-nucleotide polymorphisms Childhood obesity Fat mass and obesity associated Gene AKT1 AKTIP |
topic |
Single-nucleotide polymorphisms Childhood obesity Fat mass and obesity associated Gene AKT1 AKTIP |
description |
Abstract Objective: Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures for the prevention of obesity. The aim of this study was to assess the association between the FTO, AKT1, and AKTIP genes and childhood obesity and insulin resistance. Methods: This was a case-control study in which SNPs in the FTO (rs99396096), AKT1, and AKTIP genes were genotyped in groups of controls and obese/overweight children. The study included 195 obese/overweight children and 153 control subjects. Results: As expected, the obese/overweight group subjects had higher body mass index, higher fasting glucose, HOMA-IR index, total cholesterol, low-density lipoprotein, and triglycerides. However, no significant differences were observed in genes polymorphisms genotype or allele frequencies. Conclusion: The present results suggest that AKT1, FTO, and AKTIP polymorphisms were not associated with obesity/overweight in Brazilians children. Future studies on the genetics of obesity in Brazilian children and their environment interactions are needed. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572016000600521 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572016000600521 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2015.12.007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.92 n.5 2016 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
instacron_str |
SBPE |
institution |
SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
repository.name.fl_str_mv |
Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
repository.mail.fl_str_mv |
||jped@jped.com.br |
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1752122320861790208 |