Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines

Detalhes bibliográficos
Autor(a) principal: Rodrigues,Mauricio M.
Data de Publicação: 2003
Outros Autores: Boscardin,Silvia B., Vasconcelos,José R., Hiyane,Meire I., Salay,Gerson, Soares,Irene S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652003000400005
Resumo: Obligatory intracellular parasites such as Plasmodium sp, Trypanosoma cruzi, Toxoplasma gondii and Leishmania sp are responsible for the infection of hundreds of millions of individuals every year. These parasites can deliver antigens to the host cell cytoplasm that are presented through MHC class I molecules to protective CD8 T cells. The in vivo priming conditions of specific CD8 T cells during natural infection are largely unknown and remain as an area that has been poorly explored. The antiparasitic mechanisms mediated by CD8 T cells include both interferon-g-dependent and -independent pathways. The fact that CD8 T cells are potent inhibitors of parasitic development prompted many investigators to explore whether induction of these T cells can be a feasible strategy for the development of effective subunit vaccines against these parasitic diseases. Studies performed on experimental models supported the hypothesis that CD8 T cells induced by recombinant viral vectors or DNA vaccines could serve as the basis for human vaccination. Regimens of immunization consisting of two different vectors (heterologous prime-boost) are much more efficient in terms of expansion of protective CD8 T lymphocytes than immunization with a single vector. The results obtained using experimental models have led to clinical vaccination trials that are currently underway.
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spelling Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccinesCD8parasitesimmunityvaccineObligatory intracellular parasites such as Plasmodium sp, Trypanosoma cruzi, Toxoplasma gondii and Leishmania sp are responsible for the infection of hundreds of millions of individuals every year. These parasites can deliver antigens to the host cell cytoplasm that are presented through MHC class I molecules to protective CD8 T cells. The in vivo priming conditions of specific CD8 T cells during natural infection are largely unknown and remain as an area that has been poorly explored. The antiparasitic mechanisms mediated by CD8 T cells include both interferon-g-dependent and -independent pathways. The fact that CD8 T cells are potent inhibitors of parasitic development prompted many investigators to explore whether induction of these T cells can be a feasible strategy for the development of effective subunit vaccines against these parasitic diseases. Studies performed on experimental models supported the hypothesis that CD8 T cells induced by recombinant viral vectors or DNA vaccines could serve as the basis for human vaccination. Regimens of immunization consisting of two different vectors (heterologous prime-boost) are much more efficient in terms of expansion of protective CD8 T lymphocytes than immunization with a single vector. The results obtained using experimental models have led to clinical vaccination trials that are currently underway.Academia Brasileira de Ciências2003-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652003000400005Anais da Academia Brasileira de Ciências v.75 n.4 2003reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652003000400005info:eu-repo/semantics/openAccessRodrigues,Mauricio M.Boscardin,Silvia B.Vasconcelos,José R.Hiyane,Meire I.Salay,GersonSoares,Irene S.eng2003-10-30T00:00:00Zoai:scielo:S0001-37652003000400005Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2003-10-30T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines
title Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines
spellingShingle Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines
Rodrigues,Mauricio M.
CD8
parasites
immunity
vaccine
title_short Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines
title_full Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines
title_fullStr Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines
title_full_unstemmed Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines
title_sort Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines
author Rodrigues,Mauricio M.
author_facet Rodrigues,Mauricio M.
Boscardin,Silvia B.
Vasconcelos,José R.
Hiyane,Meire I.
Salay,Gerson
Soares,Irene S.
author_role author
author2 Boscardin,Silvia B.
Vasconcelos,José R.
Hiyane,Meire I.
Salay,Gerson
Soares,Irene S.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues,Mauricio M.
Boscardin,Silvia B.
Vasconcelos,José R.
Hiyane,Meire I.
Salay,Gerson
Soares,Irene S.
dc.subject.por.fl_str_mv CD8
parasites
immunity
vaccine
topic CD8
parasites
immunity
vaccine
description Obligatory intracellular parasites such as Plasmodium sp, Trypanosoma cruzi, Toxoplasma gondii and Leishmania sp are responsible for the infection of hundreds of millions of individuals every year. These parasites can deliver antigens to the host cell cytoplasm that are presented through MHC class I molecules to protective CD8 T cells. The in vivo priming conditions of specific CD8 T cells during natural infection are largely unknown and remain as an area that has been poorly explored. The antiparasitic mechanisms mediated by CD8 T cells include both interferon-g-dependent and -independent pathways. The fact that CD8 T cells are potent inhibitors of parasitic development prompted many investigators to explore whether induction of these T cells can be a feasible strategy for the development of effective subunit vaccines against these parasitic diseases. Studies performed on experimental models supported the hypothesis that CD8 T cells induced by recombinant viral vectors or DNA vaccines could serve as the basis for human vaccination. Regimens of immunization consisting of two different vectors (heterologous prime-boost) are much more efficient in terms of expansion of protective CD8 T lymphocytes than immunization with a single vector. The results obtained using experimental models have led to clinical vaccination trials that are currently underway.
publishDate 2003
dc.date.none.fl_str_mv 2003-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652003000400005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652003000400005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0001-37652003000400005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.75 n.4 2003
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
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reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
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