Treatment of venous ulcers with growth factors: systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Carvalho,Magali Rezende de
Data de Publicação: 2019
Outros Autores: Silveira,Isabelle Andrade, Oliveira,Beatriz Guitton Renaud Baptista de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Enfermagem (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672019000100200
Resumo: ABSTRACT Objective: To identify evidence about the effects of growth factor application on venous ulcer healing. Method: Systematic review and meta-analysis, including Randomized Clinical Trials. Searches: Ovid MEDLINE, EMBASE, CINAHL, Cochrane CENTRAL, LILACS, Web of Science, Digital Library of Theses and Dissertations; Google Scholar and list of references. Results: 802 participants were recruited from the 10 included studies: 472 in the intervention group (growth factors) and 330 as control. The relative risk for the complete healing outcome was 1.06 [95% CI 0.92-1.22], p = 0.41. Participants who received Platelet-Rich Plasma and Epidermal Growth Factor showed a slight tendency to achieve complete healing, but without statistical relevance (p <0.05). Most of the studies were classified as moderate risk of bias. Conclusion: The effect of the application of growth factors for complete healing in venous ulcers is not clear, and clinical trials with methodological quality are required for more accurate recommendations.
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spelling Treatment of venous ulcers with growth factors: systematic review and meta-analysisIntercellular Signaling Peptides and ProteinsVaricose UlcerHealingEvidence-Based NursingNursing CareABSTRACT Objective: To identify evidence about the effects of growth factor application on venous ulcer healing. Method: Systematic review and meta-analysis, including Randomized Clinical Trials. Searches: Ovid MEDLINE, EMBASE, CINAHL, Cochrane CENTRAL, LILACS, Web of Science, Digital Library of Theses and Dissertations; Google Scholar and list of references. Results: 802 participants were recruited from the 10 included studies: 472 in the intervention group (growth factors) and 330 as control. The relative risk for the complete healing outcome was 1.06 [95% CI 0.92-1.22], p = 0.41. Participants who received Platelet-Rich Plasma and Epidermal Growth Factor showed a slight tendency to achieve complete healing, but without statistical relevance (p <0.05). Most of the studies were classified as moderate risk of bias. Conclusion: The effect of the application of growth factors for complete healing in venous ulcers is not clear, and clinical trials with methodological quality are required for more accurate recommendations.Associação Brasileira de Enfermagem2019-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672019000100200Revista Brasileira de Enfermagem v.72 n.1 2019reponame:Revista Brasileira de Enfermagem (Online)instname:Associação Brasileira de Enfermagem (ABEN)instacron:ABEN10.1590/0034-7167-2017-0865info:eu-repo/semantics/openAccessCarvalho,Magali Rezende deSilveira,Isabelle AndradeOliveira,Beatriz Guitton Renaud Baptista deeng2019-03-19T00:00:00Zoai:scielo:S0034-71672019000100200Revistahttp://www.scielo.br/rebenhttps://old.scielo.br/oai/scielo-oai.phpreben@abennacional.org.br||telma.garcia@abennacional.org.br|| editorreben@abennacional.org.br1984-04460034-7167opendoar:2019-03-19T00:00Revista Brasileira de Enfermagem (Online) - Associação Brasileira de Enfermagem (ABEN)false
dc.title.none.fl_str_mv Treatment of venous ulcers with growth factors: systematic review and meta-analysis
title Treatment of venous ulcers with growth factors: systematic review and meta-analysis
spellingShingle Treatment of venous ulcers with growth factors: systematic review and meta-analysis
Carvalho,Magali Rezende de
Intercellular Signaling Peptides and Proteins
Varicose Ulcer
Healing
Evidence-Based Nursing
Nursing Care
title_short Treatment of venous ulcers with growth factors: systematic review and meta-analysis
title_full Treatment of venous ulcers with growth factors: systematic review and meta-analysis
title_fullStr Treatment of venous ulcers with growth factors: systematic review and meta-analysis
title_full_unstemmed Treatment of venous ulcers with growth factors: systematic review and meta-analysis
title_sort Treatment of venous ulcers with growth factors: systematic review and meta-analysis
author Carvalho,Magali Rezende de
author_facet Carvalho,Magali Rezende de
Silveira,Isabelle Andrade
Oliveira,Beatriz Guitton Renaud Baptista de
author_role author
author2 Silveira,Isabelle Andrade
Oliveira,Beatriz Guitton Renaud Baptista de
author2_role author
author
dc.contributor.author.fl_str_mv Carvalho,Magali Rezende de
Silveira,Isabelle Andrade
Oliveira,Beatriz Guitton Renaud Baptista de
dc.subject.por.fl_str_mv Intercellular Signaling Peptides and Proteins
Varicose Ulcer
Healing
Evidence-Based Nursing
Nursing Care
topic Intercellular Signaling Peptides and Proteins
Varicose Ulcer
Healing
Evidence-Based Nursing
Nursing Care
description ABSTRACT Objective: To identify evidence about the effects of growth factor application on venous ulcer healing. Method: Systematic review and meta-analysis, including Randomized Clinical Trials. Searches: Ovid MEDLINE, EMBASE, CINAHL, Cochrane CENTRAL, LILACS, Web of Science, Digital Library of Theses and Dissertations; Google Scholar and list of references. Results: 802 participants were recruited from the 10 included studies: 472 in the intervention group (growth factors) and 330 as control. The relative risk for the complete healing outcome was 1.06 [95% CI 0.92-1.22], p = 0.41. Participants who received Platelet-Rich Plasma and Epidermal Growth Factor showed a slight tendency to achieve complete healing, but without statistical relevance (p <0.05). Most of the studies were classified as moderate risk of bias. Conclusion: The effect of the application of growth factors for complete healing in venous ulcers is not clear, and clinical trials with methodological quality are required for more accurate recommendations.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672019000100200
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672019000100200
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0034-7167-2017-0865
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Enfermagem
publisher.none.fl_str_mv Associação Brasileira de Enfermagem
dc.source.none.fl_str_mv Revista Brasileira de Enfermagem v.72 n.1 2019
reponame:Revista Brasileira de Enfermagem (Online)
instname:Associação Brasileira de Enfermagem (ABEN)
instacron:ABEN
instname_str Associação Brasileira de Enfermagem (ABEN)
instacron_str ABEN
institution ABEN
reponame_str Revista Brasileira de Enfermagem (Online)
collection Revista Brasileira de Enfermagem (Online)
repository.name.fl_str_mv Revista Brasileira de Enfermagem (Online) - Associação Brasileira de Enfermagem (ABEN)
repository.mail.fl_str_mv reben@abennacional.org.br||telma.garcia@abennacional.org.br|| editorreben@abennacional.org.br
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