Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors

Bibliographic Details
Main Author: Rego,Eduardo M.
Publication Date: 2008
Other Authors: Santana-Lemos,Bárbara A. A., Tamarozzi,Mirela B.
Format: Article
Language: eng
Source: Revista brasileira de hematologia e hemoterapia (Online)
Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000800009
Summary: Differentiation syndrome is a treatment complication which can occur in acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO), which is characterized by enhanced leukocyte transmigration. Several cellular and molecular mechanisms participate in differentiation syndrome development. This review discusses the changes in expression of adhesion molecules induced during ATRA and ATO treatments and their possible implications in the pathogenesis of this potentially fatal complication.
id ABHHTC-1_6a836936f7e7be0524b3d05c38ff5cbc
oai_identifier_str oai:scielo:S1516-84842008000800009
network_acronym_str ABHHTC-1
network_name_str Revista brasileira de hematologia e hemoterapia (Online)
repository_id_str
spelling Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factorsAcute promyelocytic leukemiaadhesion moleculesretinoidsarsenic trioxideDifferentiation syndrome is a treatment complication which can occur in acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO), which is characterized by enhanced leukocyte transmigration. Several cellular and molecular mechanisms participate in differentiation syndrome development. This review discusses the changes in expression of adhesion molecules induced during ATRA and ATO treatments and their possible implications in the pathogenesis of this potentially fatal complication.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000800009Revista Brasileira de Hematologia e Hemoterapia v.30 suppl.2 2008reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.1590/S1516-84842008000800009info:eu-repo/semantics/openAccessRego,Eduardo M.Santana-Lemos,Bárbara A. A.Tamarozzi,Mirela B.eng2008-12-09T00:00:00Zoai:scielo:S1516-84842008000800009Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2008-12-09T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false
dc.title.none.fl_str_mv Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
title Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
spellingShingle Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
Rego,Eduardo M.
Acute promyelocytic leukemia
adhesion molecules
retinoids
arsenic trioxide
title_short Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
title_full Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
title_fullStr Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
title_full_unstemmed Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
title_sort Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
author Rego,Eduardo M.
author_facet Rego,Eduardo M.
Santana-Lemos,Bárbara A. A.
Tamarozzi,Mirela B.
author_role author
author2 Santana-Lemos,Bárbara A. A.
Tamarozzi,Mirela B.
author2_role author
author
dc.contributor.author.fl_str_mv Rego,Eduardo M.
Santana-Lemos,Bárbara A. A.
Tamarozzi,Mirela B.
dc.subject.por.fl_str_mv Acute promyelocytic leukemia
adhesion molecules
retinoids
arsenic trioxide
topic Acute promyelocytic leukemia
adhesion molecules
retinoids
arsenic trioxide
description Differentiation syndrome is a treatment complication which can occur in acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO), which is characterized by enhanced leukocyte transmigration. Several cellular and molecular mechanisms participate in differentiation syndrome development. This review discusses the changes in expression of adhesion molecules induced during ATRA and ATO treatments and their possible implications in the pathogenesis of this potentially fatal complication.
publishDate 2008
dc.date.none.fl_str_mv 2008-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000800009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000800009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-84842008000800009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
dc.source.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia v.30 suppl.2 2008
reponame:Revista brasileira de hematologia e hemoterapia (Online)
instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron:ABHHTC
instname_str Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron_str ABHHTC
institution ABHHTC
reponame_str Revista brasileira de hematologia e hemoterapia (Online)
collection Revista brasileira de hematologia e hemoterapia (Online)
repository.name.fl_str_mv Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
repository.mail.fl_str_mv sbhh@terra.com.br||secretaria@rbhh.org
_version_ 1754213109120106496

Similar Items