Late differentiation syndrome in acute promyelocytic leukemia: a challenging diagnosis
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/1856 |
Resumo: | Detailed knowledge about differentiation syndrome (DS) has remained limited. There are 2 large studies conducted by the Spanish workgroup PETHEMA (Programa Español de Tratamientos en Hematología; Spanish Program on Hematology Treatments) and the European group trial (LPA 96-99 and APL 93) in which the incidence, characteristics, prognostic factors and outcome of patients developing DS are evaluated. Both have described the median time of DS development between 10 and 12 days. The severity of the DS has been evaluated in the study conducted by PETHEMA, and severe DS usually occurs at the beginning of the treatment (median of 6 days), as compared with moderate DS (median of 15 days). We report here in two cases of late severe DS, with late diagnosis due to both time and form of presentation. We discuss the physiopathology, clinical presentation, prophylaxis and treatment of DS. |
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Late differentiation syndrome in acute promyelocytic leukemia: a challenging diagnosisdifferentiation syndromeacute promyelocytic leukemiaall trans retinoic acidDetailed knowledge about differentiation syndrome (DS) has remained limited. There are 2 large studies conducted by the Spanish workgroup PETHEMA (Programa Español de Tratamientos en Hematología; Spanish Program on Hematology Treatments) and the European group trial (LPA 96-99 and APL 93) in which the incidence, characteristics, prognostic factors and outcome of patients developing DS are evaluated. Both have described the median time of DS development between 10 and 12 days. The severity of the DS has been evaluated in the study conducted by PETHEMA, and severe DS usually occurs at the beginning of the treatment (median of 6 days), as compared with moderate DS (median of 15 days). We report here in two cases of late severe DS, with late diagnosis due to both time and form of presentation. We discuss the physiopathology, clinical presentation, prophylaxis and treatment of DS.PagePressRepositório Científico do Centro Hospitalar do PortoCabral, R.Caballero, J.Alonso, S.Dávila, J.Cabrero, M.Caballero, D.Vázquez, L.Sánchez-Guijo, F.López, L.Cañizo, M.Mateos, M.González, M.2015-10-06T13:20:41Z2014-11-19T00:00:00Z2014-11-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/1856engHematol Rep. 2014 Nov 19;6(4):56542038-832210.4081/hr.2014.5654info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-05T12:40:24ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Late differentiation syndrome in acute promyelocytic leukemia: a challenging diagnosis |
title |
Late differentiation syndrome in acute promyelocytic leukemia: a challenging diagnosis |
spellingShingle |
Late differentiation syndrome in acute promyelocytic leukemia: a challenging diagnosis Cabral, R. differentiation syndrome acute promyelocytic leukemia all trans retinoic acid |
title_short |
Late differentiation syndrome in acute promyelocytic leukemia: a challenging diagnosis |
title_full |
Late differentiation syndrome in acute promyelocytic leukemia: a challenging diagnosis |
title_fullStr |
Late differentiation syndrome in acute promyelocytic leukemia: a challenging diagnosis |
title_full_unstemmed |
Late differentiation syndrome in acute promyelocytic leukemia: a challenging diagnosis |
title_sort |
Late differentiation syndrome in acute promyelocytic leukemia: a challenging diagnosis |
author |
Cabral, R. |
author_facet |
Cabral, R. Caballero, J. Alonso, S. Dávila, J. Cabrero, M. Caballero, D. Vázquez, L. Sánchez-Guijo, F. López, L. Cañizo, M. Mateos, M. González, M. |
author_role |
author |
author2 |
Caballero, J. Alonso, S. Dávila, J. Cabrero, M. Caballero, D. Vázquez, L. Sánchez-Guijo, F. López, L. Cañizo, M. Mateos, M. González, M. |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar do Porto |
dc.contributor.author.fl_str_mv |
Cabral, R. Caballero, J. Alonso, S. Dávila, J. Cabrero, M. Caballero, D. Vázquez, L. Sánchez-Guijo, F. López, L. Cañizo, M. Mateos, M. González, M. |
dc.subject.por.fl_str_mv |
differentiation syndrome acute promyelocytic leukemia all trans retinoic acid |
topic |
differentiation syndrome acute promyelocytic leukemia all trans retinoic acid |
description |
Detailed knowledge about differentiation syndrome (DS) has remained limited. There are 2 large studies conducted by the Spanish workgroup PETHEMA (Programa Español de Tratamientos en Hematología; Spanish Program on Hematology Treatments) and the European group trial (LPA 96-99 and APL 93) in which the incidence, characteristics, prognostic factors and outcome of patients developing DS are evaluated. Both have described the median time of DS development between 10 and 12 days. The severity of the DS has been evaluated in the study conducted by PETHEMA, and severe DS usually occurs at the beginning of the treatment (median of 6 days), as compared with moderate DS (median of 15 days). We report here in two cases of late severe DS, with late diagnosis due to both time and form of presentation. We discuss the physiopathology, clinical presentation, prophylaxis and treatment of DS. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-11-19T00:00:00Z 2014-11-19T00:00:00Z 2015-10-06T13:20:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/1856 |
url |
http://hdl.handle.net/10400.16/1856 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Hematol Rep. 2014 Nov 19;6(4):5654 2038-8322 10.4081/hr.2014.5654 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
PagePress |
publisher.none.fl_str_mv |
PagePress |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777301180566732800 |