Treatment of hemifacial spasm with botulinum toxin type a: effective, long lasting and well tolerated
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000200003 |
Resumo: | ABSTRACT Hemifacial spasm (HFS) is a common movement disorder characterized by involuntary tonic or clonic contractions of the muscles innervated by the facial nerve. Objective To evaluate the long-term effect of botulinum toxin type A (BTX-A) in the treatment of HFS. Methods A retrospective analysis of patients treated at the Movement Disorders Outpatient Clinic in the Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba, from 2009 to 2013 was carried out. A total of 550 BTX-A injections were administered to 100 HFS patients. Results Mean duration of improvement following each injection session was 3.1 months, mean latency to detection of improvement was 7.1 days and mean success rate was 94.7%. Patients were evaluated at an interval of 5.8 months after each application. Adverse effects, which were mostly minor, were observed in 37% of the patients at least once during follow-up. The most frequent was ptosis (35.1%). Conclusion Treatment of HFS with BTX-A was effective, sustainable and safe and had minimal, well-tolerated side effects. |
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Treatment of hemifacial spasm with botulinum toxin type a: effective, long lasting and well toleratedbotulinum toxinsbotulinum toxin type Ahemifacial spasmABSTRACT Hemifacial spasm (HFS) is a common movement disorder characterized by involuntary tonic or clonic contractions of the muscles innervated by the facial nerve. Objective To evaluate the long-term effect of botulinum toxin type A (BTX-A) in the treatment of HFS. Methods A retrospective analysis of patients treated at the Movement Disorders Outpatient Clinic in the Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba, from 2009 to 2013 was carried out. A total of 550 BTX-A injections were administered to 100 HFS patients. Results Mean duration of improvement following each injection session was 3.1 months, mean latency to detection of improvement was 7.1 days and mean success rate was 94.7%. Patients were evaluated at an interval of 5.8 months after each application. Adverse effects, which were mostly minor, were observed in 37% of the patients at least once during follow-up. The most frequent was ptosis (35.1%). Conclusion Treatment of HFS with BTX-A was effective, sustainable and safe and had minimal, well-tolerated side effects.Academia Brasileira de Neurologia - ABNEURO2017-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000200003Arquivos de Neuro-Psiquiatria v.75 n.2 2017reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20160191info:eu-repo/semantics/openAccessBatisti,Jean Pierre MetteKleinfelder,Alais Daiane FadiniGalli,Natália BassalobreMoro,AdrianaMunhoz,Renato PuppiTeive,Hélio Afonso Ghizonieng2017-02-17T00:00:00Zoai:scielo:S0004-282X2017000200003Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2017-02-17T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Treatment of hemifacial spasm with botulinum toxin type a: effective, long lasting and well tolerated |
title |
Treatment of hemifacial spasm with botulinum toxin type a: effective, long lasting and well tolerated |
spellingShingle |
Treatment of hemifacial spasm with botulinum toxin type a: effective, long lasting and well tolerated Batisti,Jean Pierre Mette botulinum toxins botulinum toxin type A hemifacial spasm |
title_short |
Treatment of hemifacial spasm with botulinum toxin type a: effective, long lasting and well tolerated |
title_full |
Treatment of hemifacial spasm with botulinum toxin type a: effective, long lasting and well tolerated |
title_fullStr |
Treatment of hemifacial spasm with botulinum toxin type a: effective, long lasting and well tolerated |
title_full_unstemmed |
Treatment of hemifacial spasm with botulinum toxin type a: effective, long lasting and well tolerated |
title_sort |
Treatment of hemifacial spasm with botulinum toxin type a: effective, long lasting and well tolerated |
author |
Batisti,Jean Pierre Mette |
author_facet |
Batisti,Jean Pierre Mette Kleinfelder,Alais Daiane Fadini Galli,Natália Bassalobre Moro,Adriana Munhoz,Renato Puppi Teive,Hélio Afonso Ghizoni |
author_role |
author |
author2 |
Kleinfelder,Alais Daiane Fadini Galli,Natália Bassalobre Moro,Adriana Munhoz,Renato Puppi Teive,Hélio Afonso Ghizoni |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Batisti,Jean Pierre Mette Kleinfelder,Alais Daiane Fadini Galli,Natália Bassalobre Moro,Adriana Munhoz,Renato Puppi Teive,Hélio Afonso Ghizoni |
dc.subject.por.fl_str_mv |
botulinum toxins botulinum toxin type A hemifacial spasm |
topic |
botulinum toxins botulinum toxin type A hemifacial spasm |
description |
ABSTRACT Hemifacial spasm (HFS) is a common movement disorder characterized by involuntary tonic or clonic contractions of the muscles innervated by the facial nerve. Objective To evaluate the long-term effect of botulinum toxin type A (BTX-A) in the treatment of HFS. Methods A retrospective analysis of patients treated at the Movement Disorders Outpatient Clinic in the Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba, from 2009 to 2013 was carried out. A total of 550 BTX-A injections were administered to 100 HFS patients. Results Mean duration of improvement following each injection session was 3.1 months, mean latency to detection of improvement was 7.1 days and mean success rate was 94.7%. Patients were evaluated at an interval of 5.8 months after each application. Adverse effects, which were mostly minor, were observed in 37% of the patients at least once during follow-up. The most frequent was ptosis (35.1%). Conclusion Treatment of HFS with BTX-A was effective, sustainable and safe and had minimal, well-tolerated side effects. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000200003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000200003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20160191 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.75 n.2 2017 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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