Multiple sclerosis and herpesvirus interaction
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000727 |
Resumo: | Multiple sclerosis is the most common autoimmune inflammatory demyelinating disease of the central nervous system, and its etiology is believed to have both genetic and environmental components. Several viruses have already been implicated as triggers and there are several studies that implicate members of the Herpesviridae family in the pathogenesis of MS. The most important characteristic of these viruses is that they have periods of latency and exacerbations within their biological sanctuary, the central nervous system. The Epstein-Barr, cytomegalovirus, human herpesvirus 6 and human herpesvirus 7 viruses are the members that are most studied as being possible triggers of multiple sclerosis. According to evidence in the literature, the herpesvirus family is strongly involved in the pathogenesis of this disease, but it is unlikely that they are the only component responsible for its development. There are probably multiple triggers and more studies are necessary to investigate and define these interactions. |
id |
ABNEURO-1_cc07c7bab113b87f69b528b4c966dc62 |
---|---|
oai_identifier_str |
oai:scielo:S0004-282X2013001000727 |
network_acronym_str |
ABNEURO-1 |
network_name_str |
Arquivos de neuro-psiquiatria (Online) |
repository_id_str |
|
spelling |
Multiple sclerosis and herpesvirus interactiondemyelinating diseasebmultiple sclerosisherpesvirusdoenca desmielinizanteesclerose multiplaherpesvirusMultiple sclerosis is the most common autoimmune inflammatory demyelinating disease of the central nervous system, and its etiology is believed to have both genetic and environmental components. Several viruses have already been implicated as triggers and there are several studies that implicate members of the Herpesviridae family in the pathogenesis of MS. The most important characteristic of these viruses is that they have periods of latency and exacerbations within their biological sanctuary, the central nervous system. The Epstein-Barr, cytomegalovirus, human herpesvirus 6 and human herpesvirus 7 viruses are the members that are most studied as being possible triggers of multiple sclerosis. According to evidence in the literature, the herpesvirus family is strongly involved in the pathogenesis of this disease, but it is unlikely that they are the only component responsible for its development. There are probably multiple triggers and more studies are necessary to investigate and define these interactions.Academia Brasileira de Neurologia - ABNEURO2013-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000727Arquivos de Neuro-Psiquiatria v.71 n.9B 2013reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20130160info:eu-repo/semantics/openAccessOlival,Guilherme Sciascia doLima,Bruna MendoncaSumita,Laura M.Serafim,VitorFink,Maria CristinaNali,Luis HenriqueRomano,Camila MaltaThomaz,Rodrigo BarbosaCavenaghi,Vitor BreseghelloTilbery,Charles PeterPenalva-de-Oliveira,Augusto Cesareng2013-10-10T00:00:00Zoai:scielo:S0004-282X2013001000727Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2013-10-10T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Multiple sclerosis and herpesvirus interaction |
title |
Multiple sclerosis and herpesvirus interaction |
spellingShingle |
Multiple sclerosis and herpesvirus interaction Olival,Guilherme Sciascia do demyelinating disease bmultiple sclerosis herpesvirus doenca desmielinizante esclerose multipla herpesvirus |
title_short |
Multiple sclerosis and herpesvirus interaction |
title_full |
Multiple sclerosis and herpesvirus interaction |
title_fullStr |
Multiple sclerosis and herpesvirus interaction |
title_full_unstemmed |
Multiple sclerosis and herpesvirus interaction |
title_sort |
Multiple sclerosis and herpesvirus interaction |
author |
Olival,Guilherme Sciascia do |
author_facet |
Olival,Guilherme Sciascia do Lima,Bruna Mendonca Sumita,Laura M. Serafim,Vitor Fink,Maria Cristina Nali,Luis Henrique Romano,Camila Malta Thomaz,Rodrigo Barbosa Cavenaghi,Vitor Breseghello Tilbery,Charles Peter Penalva-de-Oliveira,Augusto Cesar |
author_role |
author |
author2 |
Lima,Bruna Mendonca Sumita,Laura M. Serafim,Vitor Fink,Maria Cristina Nali,Luis Henrique Romano,Camila Malta Thomaz,Rodrigo Barbosa Cavenaghi,Vitor Breseghello Tilbery,Charles Peter Penalva-de-Oliveira,Augusto Cesar |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Olival,Guilherme Sciascia do Lima,Bruna Mendonca Sumita,Laura M. Serafim,Vitor Fink,Maria Cristina Nali,Luis Henrique Romano,Camila Malta Thomaz,Rodrigo Barbosa Cavenaghi,Vitor Breseghello Tilbery,Charles Peter Penalva-de-Oliveira,Augusto Cesar |
dc.subject.por.fl_str_mv |
demyelinating disease bmultiple sclerosis herpesvirus doenca desmielinizante esclerose multipla herpesvirus |
topic |
demyelinating disease bmultiple sclerosis herpesvirus doenca desmielinizante esclerose multipla herpesvirus |
description |
Multiple sclerosis is the most common autoimmune inflammatory demyelinating disease of the central nervous system, and its etiology is believed to have both genetic and environmental components. Several viruses have already been implicated as triggers and there are several studies that implicate members of the Herpesviridae family in the pathogenesis of MS. The most important characteristic of these viruses is that they have periods of latency and exacerbations within their biological sanctuary, the central nervous system. The Epstein-Barr, cytomegalovirus, human herpesvirus 6 and human herpesvirus 7 viruses are the members that are most studied as being possible triggers of multiple sclerosis. According to evidence in the literature, the herpesvirus family is strongly involved in the pathogenesis of this disease, but it is unlikely that they are the only component responsible for its development. There are probably multiple triggers and more studies are necessary to investigate and define these interactions. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000727 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000727 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282X20130160 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.71 n.9B 2013 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212775339491328 |