Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis

Detalhes bibliográficos
Autor(a) principal: Kosugi,Eduardo Macoto
Data de Publicação: 2016
Outros Autores: Moussalem,Guilherme Figner, Simões,Juliana Caminha, Souza,Rafael de Paula e Silva Felici de, Chen,Vitor Guo, Saraceni Neto,Paulo, Mendes Neto,José Arruda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Otorhinolaryngology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000200191
Resumo: ABSTRACT INTRODUCTION: Chronic rhinosinusitis (CRS) is termed difficult-to-treat when patients do not reach acceptable level of control despite adequate surgery, intranasal corticosteroid treatment and up to 2 short courses of systemic antibiotics or corticosteroids in the preceding year. Recently, high-volume corticosteroid nasal irrigations have been recommended for CRS treatment. OBJECTIVE: To assess high-volume budesonide nasal irrigations for difficult-to-treat CRS. METHODS: Prospective uncontrolled intervention trial. Participants were assessed before- and 3 months after nasal irrigation with 1 mg of budesonide in 500 mL of saline solution daily for 2 days. Subjective (satisfactory clinical improvement) and objective (SNOT-22 questionnaire and Lund-Kennedy endoscopic scores) assessments were performed. RESULTS: Sixteen patients were included, and 13 (81.3%) described satisfactory clinical improvement. SNOT-22 mean scores (50.2-29.6; p = 0.006) and Lund-Kennedy mean scores (8.8-5.1; p = 0.01) improved significantly. Individually, 75% of patients improved SNOT-22 scores, and 75% improved Lund-Kennedy scores after high volume budesonide nasal irrigations. CONCLUSION: High-volume corticosteroid nasal irrigations are a good option in difficult-to-treat CRS control of disease, reaching 81.3% success control and significant improvement of SNOT-22 and Lund-Kennedy scores.
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spelling Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitisSinusitisNasal polypsTherapeutic irrigationsCorticosteroidsEndoscopyABSTRACT INTRODUCTION: Chronic rhinosinusitis (CRS) is termed difficult-to-treat when patients do not reach acceptable level of control despite adequate surgery, intranasal corticosteroid treatment and up to 2 short courses of systemic antibiotics or corticosteroids in the preceding year. Recently, high-volume corticosteroid nasal irrigations have been recommended for CRS treatment. OBJECTIVE: To assess high-volume budesonide nasal irrigations for difficult-to-treat CRS. METHODS: Prospective uncontrolled intervention trial. Participants were assessed before- and 3 months after nasal irrigation with 1 mg of budesonide in 500 mL of saline solution daily for 2 days. Subjective (satisfactory clinical improvement) and objective (SNOT-22 questionnaire and Lund-Kennedy endoscopic scores) assessments were performed. RESULTS: Sixteen patients were included, and 13 (81.3%) described satisfactory clinical improvement. SNOT-22 mean scores (50.2-29.6; p = 0.006) and Lund-Kennedy mean scores (8.8-5.1; p = 0.01) improved significantly. Individually, 75% of patients improved SNOT-22 scores, and 75% improved Lund-Kennedy scores after high volume budesonide nasal irrigations. CONCLUSION: High-volume corticosteroid nasal irrigations are a good option in difficult-to-treat CRS control of disease, reaching 81.3% success control and significant improvement of SNOT-22 and Lund-Kennedy scores.Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.2016-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000200191Brazilian Journal of Otorhinolaryngology v.82 n.2 2016reponame:Brazilian Journal of Otorhinolaryngologyinstname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)instacron:ABORL-CCF10.1016/j.bjorl.2015.03.014info:eu-repo/semantics/openAccessKosugi,Eduardo MacotoMoussalem,Guilherme FignerSimões,Juliana CaminhaSouza,Rafael de Paula e Silva Felici deChen,Vitor GuoSaraceni Neto,PauloMendes Neto,José Arrudaeng2016-04-29T00:00:00Zoai:scielo:S1808-86942016000200191Revistahttp://www.bjorl.org.br/https://old.scielo.br/oai/scielo-oai.phprevista@aborlccf.org.br||revista@aborlccf.org.br1808-86861808-8686opendoar:2016-04-29T00:00Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)false
dc.title.none.fl_str_mv Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis
title Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis
spellingShingle Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis
Kosugi,Eduardo Macoto
Sinusitis
Nasal polyps
Therapeutic irrigations
Corticosteroids
Endoscopy
title_short Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis
title_full Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis
title_fullStr Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis
title_full_unstemmed Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis
title_sort Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis
author Kosugi,Eduardo Macoto
author_facet Kosugi,Eduardo Macoto
Moussalem,Guilherme Figner
Simões,Juliana Caminha
Souza,Rafael de Paula e Silva Felici de
Chen,Vitor Guo
Saraceni Neto,Paulo
Mendes Neto,José Arruda
author_role author
author2 Moussalem,Guilherme Figner
Simões,Juliana Caminha
Souza,Rafael de Paula e Silva Felici de
Chen,Vitor Guo
Saraceni Neto,Paulo
Mendes Neto,José Arruda
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kosugi,Eduardo Macoto
Moussalem,Guilherme Figner
Simões,Juliana Caminha
Souza,Rafael de Paula e Silva Felici de
Chen,Vitor Guo
Saraceni Neto,Paulo
Mendes Neto,José Arruda
dc.subject.por.fl_str_mv Sinusitis
Nasal polyps
Therapeutic irrigations
Corticosteroids
Endoscopy
topic Sinusitis
Nasal polyps
Therapeutic irrigations
Corticosteroids
Endoscopy
description ABSTRACT INTRODUCTION: Chronic rhinosinusitis (CRS) is termed difficult-to-treat when patients do not reach acceptable level of control despite adequate surgery, intranasal corticosteroid treatment and up to 2 short courses of systemic antibiotics or corticosteroids in the preceding year. Recently, high-volume corticosteroid nasal irrigations have been recommended for CRS treatment. OBJECTIVE: To assess high-volume budesonide nasal irrigations for difficult-to-treat CRS. METHODS: Prospective uncontrolled intervention trial. Participants were assessed before- and 3 months after nasal irrigation with 1 mg of budesonide in 500 mL of saline solution daily for 2 days. Subjective (satisfactory clinical improvement) and objective (SNOT-22 questionnaire and Lund-Kennedy endoscopic scores) assessments were performed. RESULTS: Sixteen patients were included, and 13 (81.3%) described satisfactory clinical improvement. SNOT-22 mean scores (50.2-29.6; p = 0.006) and Lund-Kennedy mean scores (8.8-5.1; p = 0.01) improved significantly. Individually, 75% of patients improved SNOT-22 scores, and 75% improved Lund-Kennedy scores after high volume budesonide nasal irrigations. CONCLUSION: High-volume corticosteroid nasal irrigations are a good option in difficult-to-treat CRS control of disease, reaching 81.3% success control and significant improvement of SNOT-22 and Lund-Kennedy scores.
publishDate 2016
dc.date.none.fl_str_mv 2016-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000200191
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000200191
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjorl.2015.03.014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
dc.source.none.fl_str_mv Brazilian Journal of Otorhinolaryngology v.82 n.2 2016
reponame:Brazilian Journal of Otorhinolaryngology
instname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron:ABORL-CCF
instname_str Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron_str ABORL-CCF
institution ABORL-CCF
reponame_str Brazilian Journal of Otorhinolaryngology
collection Brazilian Journal of Otorhinolaryngology
repository.name.fl_str_mv Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
repository.mail.fl_str_mv revista@aborlccf.org.br||revista@aborlccf.org.br
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