Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a review

Detalhes bibliográficos
Autor(a) principal: Campos,Emille Magalhães Neves
Data de Publicação: 2021
Outros Autores: Rodrigues,Laís Damasceno, Oliveira,Leandro Freitas, Santos,Júlio César Claudino dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642021000200164
Resumo: ABSTRACT. Considering the variety of mechanisms of Herpes simplex virus (HSV-1) contamination and its broad invasive potential of the nervous system, a life-long latent infection is established. Infected adult individuals may be susceptible to viral reactivation when under the influence of multiple stressors, especially regarding immunocompromised patients. This guides a series of neuroinflammatory events on the cerebral cortex, culminating, rarely, in encephalitis and cytotoxic / vasogenic brain edema. A sum of studies of such processes provides an explanation, even though not yet completely clarified, on how the clinical evolution to cognitive impairment and dementia might be enabled. In addition, it is of extreme importance to recognize the current dementia and cognitive deficit worldwide panorama. The aim of this literature review is to elucidate the available data upon the pathophysiology of HSV-1 infection as well as to describe the clinical panorama of the referred afflictions.
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spelling Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a reviewherpesvirus 1humancentral nervous system viral diseasesencephalitisherpes simplexcognitive dysfunctiondementiaABSTRACT. Considering the variety of mechanisms of Herpes simplex virus (HSV-1) contamination and its broad invasive potential of the nervous system, a life-long latent infection is established. Infected adult individuals may be susceptible to viral reactivation when under the influence of multiple stressors, especially regarding immunocompromised patients. This guides a series of neuroinflammatory events on the cerebral cortex, culminating, rarely, in encephalitis and cytotoxic / vasogenic brain edema. A sum of studies of such processes provides an explanation, even though not yet completely clarified, on how the clinical evolution to cognitive impairment and dementia might be enabled. In addition, it is of extreme importance to recognize the current dementia and cognitive deficit worldwide panorama. The aim of this literature review is to elucidate the available data upon the pathophysiology of HSV-1 infection as well as to describe the clinical panorama of the referred afflictions.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2021-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642021000200164Dementia & Neuropsychologia v.15 n.2 2021reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/1980-57642021dn15-020002info:eu-repo/semantics/openAccessCampos,Emille Magalhães NevesRodrigues,Laís DamascenoOliveira,Leandro FreitasSantos,Júlio César Claudino doseng2021-06-30T00:00:00Zoai:scielo:S1980-57642021000200164Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2021-06-30T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a review
title Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a review
spellingShingle Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a review
Campos,Emille Magalhães Neves
herpesvirus 1
human
central nervous system viral diseases
encephalitis
herpes simplex
cognitive dysfunction
dementia
title_short Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a review
title_full Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a review
title_fullStr Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a review
title_full_unstemmed Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a review
title_sort Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a review
author Campos,Emille Magalhães Neves
author_facet Campos,Emille Magalhães Neves
Rodrigues,Laís Damasceno
Oliveira,Leandro Freitas
Santos,Júlio César Claudino dos
author_role author
author2 Rodrigues,Laís Damasceno
Oliveira,Leandro Freitas
Santos,Júlio César Claudino dos
author2_role author
author
author
dc.contributor.author.fl_str_mv Campos,Emille Magalhães Neves
Rodrigues,Laís Damasceno
Oliveira,Leandro Freitas
Santos,Júlio César Claudino dos
dc.subject.por.fl_str_mv herpesvirus 1
human
central nervous system viral diseases
encephalitis
herpes simplex
cognitive dysfunction
dementia
topic herpesvirus 1
human
central nervous system viral diseases
encephalitis
herpes simplex
cognitive dysfunction
dementia
description ABSTRACT. Considering the variety of mechanisms of Herpes simplex virus (HSV-1) contamination and its broad invasive potential of the nervous system, a life-long latent infection is established. Infected adult individuals may be susceptible to viral reactivation when under the influence of multiple stressors, especially regarding immunocompromised patients. This guides a series of neuroinflammatory events on the cerebral cortex, culminating, rarely, in encephalitis and cytotoxic / vasogenic brain edema. A sum of studies of such processes provides an explanation, even though not yet completely clarified, on how the clinical evolution to cognitive impairment and dementia might be enabled. In addition, it is of extreme importance to recognize the current dementia and cognitive deficit worldwide panorama. The aim of this literature review is to elucidate the available data upon the pathophysiology of HSV-1 infection as well as to describe the clinical panorama of the referred afflictions.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642021000200164
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642021000200164
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1980-57642021dn15-020002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia & Neuropsychologia v.15 n.2 2021
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
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