Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | São Paulo medical journal (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000500420 |
Resumo: | ABSTRACT CONTEXT AND OBJECTIVE: The prevalence of a variety of potentially pathogenic microorganisms in cystic fibrosis patients, such as methicillin-resistant Staphylococcus aureus (MRSA), has increased over the past decade. Given the increasing prevalence of MRSA and the few data available in the literature, better understanding of the clinical repercussions of colonization by this bacterium in cystic fibrosis patients becomes essential. This study aimed to evaluate the repercussions of chronic colonization by MRSA in cystic fibrosis patients. DESIGN AND SETTING: Retrospective cohort study from January 2004 to December 2013 in a cystic fibrosis reference center. METHODS: Each patient with cystic fibrosis was evaluated for nutritional status (body mass index, BMI, and BMI percentile), pulmonary function and tomographic abnormalities (modified Bhalla scores) at the time of chronic colonization by MRSA or methicillin-susceptible Staphylococcus aureus (MSSA) and throughout the study period. RESULTS: Twenty pairs of patients were included. There were no significant differences between the groups regarding nutritional characteristics. Spirometric data showed a trend towards greater obstruction of the airways in patients with MRSA. Patients with MRSA presented greater structural damage to their lungs, demonstrated not only by the total Bhalla score but also by its parameters individually. CONCLUSIONS: Patients colonized by MRSA presented greater functional and structural respiratory impairment at the time of chronic colonization. Disease progression was also faster in patients chronically colonized by MRSA than in those with MSSA. This was shown through comparisons that avoided possible confounding variables. |
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Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort studyCystic fibrosisMethicillin-resistant Staphylococcus aureusTomographySpirometryBody mass indexABSTRACT CONTEXT AND OBJECTIVE: The prevalence of a variety of potentially pathogenic microorganisms in cystic fibrosis patients, such as methicillin-resistant Staphylococcus aureus (MRSA), has increased over the past decade. Given the increasing prevalence of MRSA and the few data available in the literature, better understanding of the clinical repercussions of colonization by this bacterium in cystic fibrosis patients becomes essential. This study aimed to evaluate the repercussions of chronic colonization by MRSA in cystic fibrosis patients. DESIGN AND SETTING: Retrospective cohort study from January 2004 to December 2013 in a cystic fibrosis reference center. METHODS: Each patient with cystic fibrosis was evaluated for nutritional status (body mass index, BMI, and BMI percentile), pulmonary function and tomographic abnormalities (modified Bhalla scores) at the time of chronic colonization by MRSA or methicillin-susceptible Staphylococcus aureus (MSSA) and throughout the study period. RESULTS: Twenty pairs of patients were included. There were no significant differences between the groups regarding nutritional characteristics. Spirometric data showed a trend towards greater obstruction of the airways in patients with MRSA. Patients with MRSA presented greater structural damage to their lungs, demonstrated not only by the total Bhalla score but also by its parameters individually. CONCLUSIONS: Patients colonized by MRSA presented greater functional and structural respiratory impairment at the time of chronic colonization. Disease progression was also faster in patients chronically colonized by MRSA than in those with MSSA. This was shown through comparisons that avoided possible confounding variables.Associação Paulista de Medicina - APM2017-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000500420Sao Paulo Medical Journal v.135 n.5 2017reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/1516-3180.2016.0350240317info:eu-repo/semantics/openAccessCohen,Renata Wrobel FolescuFolescu,Tânia WrobelDaltro,PedroBoechat,Marcia Cristina BastosLima,Danielle FerreiraMarques,Elizabeth AndradeLeão,Robson Souzaeng2017-11-30T00:00:00Zoai:scielo:S1516-31802017000500420Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2017-11-30T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse |
dc.title.none.fl_str_mv |
Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study |
title |
Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study |
spellingShingle |
Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study Cohen,Renata Wrobel Folescu Cystic fibrosis Methicillin-resistant Staphylococcus aureus Tomography Spirometry Body mass index |
title_short |
Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study |
title_full |
Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study |
title_fullStr |
Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study |
title_full_unstemmed |
Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study |
title_sort |
Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study |
author |
Cohen,Renata Wrobel Folescu |
author_facet |
Cohen,Renata Wrobel Folescu Folescu,Tânia Wrobel Daltro,Pedro Boechat,Marcia Cristina Bastos Lima,Danielle Ferreira Marques,Elizabeth Andrade Leão,Robson Souza |
author_role |
author |
author2 |
Folescu,Tânia Wrobel Daltro,Pedro Boechat,Marcia Cristina Bastos Lima,Danielle Ferreira Marques,Elizabeth Andrade Leão,Robson Souza |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Cohen,Renata Wrobel Folescu Folescu,Tânia Wrobel Daltro,Pedro Boechat,Marcia Cristina Bastos Lima,Danielle Ferreira Marques,Elizabeth Andrade Leão,Robson Souza |
dc.subject.por.fl_str_mv |
Cystic fibrosis Methicillin-resistant Staphylococcus aureus Tomography Spirometry Body mass index |
topic |
Cystic fibrosis Methicillin-resistant Staphylococcus aureus Tomography Spirometry Body mass index |
description |
ABSTRACT CONTEXT AND OBJECTIVE: The prevalence of a variety of potentially pathogenic microorganisms in cystic fibrosis patients, such as methicillin-resistant Staphylococcus aureus (MRSA), has increased over the past decade. Given the increasing prevalence of MRSA and the few data available in the literature, better understanding of the clinical repercussions of colonization by this bacterium in cystic fibrosis patients becomes essential. This study aimed to evaluate the repercussions of chronic colonization by MRSA in cystic fibrosis patients. DESIGN AND SETTING: Retrospective cohort study from January 2004 to December 2013 in a cystic fibrosis reference center. METHODS: Each patient with cystic fibrosis was evaluated for nutritional status (body mass index, BMI, and BMI percentile), pulmonary function and tomographic abnormalities (modified Bhalla scores) at the time of chronic colonization by MRSA or methicillin-susceptible Staphylococcus aureus (MSSA) and throughout the study period. RESULTS: Twenty pairs of patients were included. There were no significant differences between the groups regarding nutritional characteristics. Spirometric data showed a trend towards greater obstruction of the airways in patients with MRSA. Patients with MRSA presented greater structural damage to their lungs, demonstrated not only by the total Bhalla score but also by its parameters individually. CONCLUSIONS: Patients colonized by MRSA presented greater functional and structural respiratory impairment at the time of chronic colonization. Disease progression was also faster in patients chronically colonized by MRSA than in those with MSSA. This was shown through comparisons that avoided possible confounding variables. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000500420 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000500420 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1516-3180.2016.0350240317 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
Sao Paulo Medical Journal v.135 n.5 2017 reponame:São Paulo medical journal (Online) instname:Associação Paulista de Medicina instacron:APM |
instname_str |
Associação Paulista de Medicina |
instacron_str |
APM |
institution |
APM |
reponame_str |
São Paulo medical journal (Online) |
collection |
São Paulo medical journal (Online) |
repository.name.fl_str_mv |
São Paulo medical journal (Online) - Associação Paulista de Medicina |
repository.mail.fl_str_mv |
revistas@apm.org.br |
_version_ |
1754209265769250816 |