Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study

Detalhes bibliográficos
Autor(a) principal: Cohen, Renata Wrobel Folescu
Data de Publicação: 2017
Outros Autores: Folescu, Tânia Wrobel, Daltro, Pedro, Boechat, Marcia Cristina Bastos, Lima, Danielle Ferreira, Marques, Elizabeth Andrade, Leão, Robson Souza
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40017
Resumo: Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
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spelling Cohen, Renata Wrobel FolescuFolescu, Tânia WrobelDaltro, PedroBoechat, Marcia Cristina BastosLima, Danielle FerreiraMarques, Elizabeth AndradeLeão, Robson Souza2020-02-17T18:26:02Z2020-02-17T18:26:02Z2017COHEN, Renata Wrobel Folescu et al. Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study. São Paulo Medical Journal, São Paulo, v. 135, n. 5, p. 420-427, Oct. 2017.1516-3180https://www.arca.fiocruz.br/handle/icict/4001710.1590/1516-3180.2016.03502403171806-9460porAssociação Paulista de MedicinaChildChild, PreschoolChronic DiseaseCohort StudiesCystic Fibrosis/microbiologyFemaleHumansMaleMethicillin-Resistant Staphylococcus aureus/isolation & purificationRetrospective StudiesStaphylococcal Infections/microbiologyCystic fibrosisMethicillin-resistant Staphylococcus aureusSpirometryBody mass indexTomographyMethicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Department of Microbiology, Immunology and Parasitology. School of Medical Sciences. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Department of Microbiology, Immunology and Parasitology. School of Medical Sciences. Rio de Janeiro, RJ, Brasil.CONTEXT AND OBJECTIVE: The prevalence of a variety of potentially pathogenic microorganisms in cystic fibrosis patients, such as methicillin-resistant Staphylococcus aureus (MRSA), has increased over the past decade. Given the increasing prevalence of MRSA and the few data available in the literature, better understanding of the clinical repercussions of colonization by this bacterium in cystic fibrosis patients becomes essential. This study aimed to evaluate the repercussions of chronic colonization by MRSA in cystic fibrosis patients. DESIGN AND SETTING: Retrospective cohort study from January 2004 to December 2013 in a cystic fibrosis reference center. METHODS: Each patient with cystic fibrosis was evaluated for nutritional status (body mass index, BMI, and BMI percentile), pulmonary function and tomographic abnormalities (modified Bhalla scores) at the time of chronic colonization by MRSA or methicillin-susceptible Staphylococcus aureus (MSSA) and throughout the study period. RESULTS: Twenty pairs of patients were included. There were no significant differences between the groups regarding nutritional characteristics. Spirometric data showed a trend towards greater obstruction of the airways in patients with MRSA. Patients with MRSA presented greater structural damage to their lungs, demonstrated not only by the total Bhalla score but also by its parameters individually. CONCLUSIONS: Patients colonized by MRSA presented greater functional and structural respiratory impairment at the time of chronic colonization. Disease progression was also faster in patients chronically colonized by MRSA than in those with MSSA. This was shown through comparisons that avoided possible confounding variables.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40017/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMethicillin-resistant Staphylococcus aureus in cystic fibrosis patients - do we need to care. A cohort study.pdfMethicillin-resistant Staphylococcus aureus in cystic fibrosis patients - do we need to care. A cohort study.pdfapplication/pdf190283https://www.arca.fiocruz.br/bitstream/icict/40017/2/Methicillin-resistant%20Staphylococcus%20aureus%20in%20cystic%20fibrosis%20patients%20-%20do%20we%20need%20to%20care.%20A%20cohort%20study.pdfa1604a8130c18bbb4ee15e5a9c384d85MD52TEXTMethicillin-resistant Staphylococcus aureus in cystic fibrosis patients - do we need to care. A cohort study.pdf.txtMethicillin-resistant Staphylococcus aureus in cystic fibrosis patients - do we need to care. A cohort study.pdf.txtExtracted texttext/plain37951https://www.arca.fiocruz.br/bitstream/icict/40017/3/Methicillin-resistant%20Staphylococcus%20aureus%20in%20cystic%20fibrosis%20patients%20-%20do%20we%20need%20to%20care.%20A%20cohort%20study.pdf.txtdf2c023a7a2672205e197ca4d6b033f9MD53icict/400172020-02-25 16:04:30.493oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-02-25T19:04:30Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study
title Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study
spellingShingle Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study
Cohen, Renata Wrobel Folescu
Child
Child, Preschool
Chronic Disease
Cohort Studies
Cystic Fibrosis/microbiology
Female
Humans
Male
Methicillin-Resistant Staphylococcus aureus/isolation & purification
Retrospective Studies
Staphylococcal Infections/microbiology
Cystic fibrosis
Methicillin-resistant Staphylococcus aureus
Spirometry
Body mass index
Tomography
title_short Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study
title_full Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study
title_fullStr Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study
title_full_unstemmed Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study
title_sort Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study
author Cohen, Renata Wrobel Folescu
author_facet Cohen, Renata Wrobel Folescu
Folescu, Tânia Wrobel
Daltro, Pedro
Boechat, Marcia Cristina Bastos
Lima, Danielle Ferreira
Marques, Elizabeth Andrade
Leão, Robson Souza
author_role author
author2 Folescu, Tânia Wrobel
Daltro, Pedro
Boechat, Marcia Cristina Bastos
Lima, Danielle Ferreira
Marques, Elizabeth Andrade
Leão, Robson Souza
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cohen, Renata Wrobel Folescu
Folescu, Tânia Wrobel
Daltro, Pedro
Boechat, Marcia Cristina Bastos
Lima, Danielle Ferreira
Marques, Elizabeth Andrade
Leão, Robson Souza
dc.subject.mesh.pt_BR.fl_str_mv Child
Child, Preschool
Chronic Disease
Cohort Studies
Cystic Fibrosis/microbiology
Female
Humans
Male
Methicillin-Resistant Staphylococcus aureus/isolation & purification
Retrospective Studies
Staphylococcal Infections/microbiology
topic Child
Child, Preschool
Chronic Disease
Cohort Studies
Cystic Fibrosis/microbiology
Female
Humans
Male
Methicillin-Resistant Staphylococcus aureus/isolation & purification
Retrospective Studies
Staphylococcal Infections/microbiology
Cystic fibrosis
Methicillin-resistant Staphylococcus aureus
Spirometry
Body mass index
Tomography
dc.subject.en.pt_BR.fl_str_mv Cystic fibrosis
Methicillin-resistant Staphylococcus aureus
Spirometry
Body mass index
Tomography
description Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2020-02-17T18:26:02Z
dc.date.available.fl_str_mv 2020-02-17T18:26:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COHEN, Renata Wrobel Folescu et al. Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study. São Paulo Medical Journal, São Paulo, v. 135, n. 5, p. 420-427, Oct. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40017
dc.identifier.issn.pt_BR.fl_str_mv 1516-3180
dc.identifier.doi.none.fl_str_mv 10.1590/1516-3180.2016.0350240317
dc.identifier.eissn.none.fl_str_mv 1806-9460
identifier_str_mv COHEN, Renata Wrobel Folescu et al. Methicillin-resistant Staphylococcus aureus in cystic fibrosis patients: do we need to care? A cohort study. São Paulo Medical Journal, São Paulo, v. 135, n. 5, p. 420-427, Oct. 2017.
1516-3180
10.1590/1516-3180.2016.0350240317
1806-9460
url https://www.arca.fiocruz.br/handle/icict/40017
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Associação Paulista de Medicina
publisher.none.fl_str_mv Associação Paulista de Medicina
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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