BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival

Detalhes bibliográficos
Autor(a) principal: Pagnano, Katia Borgia Barbosa
Data de Publicação: 2014
Outros Autores: Souza, Carmino Antonio de, 1951-, Miranda, Eliana Cristina Martins, 1965-, Silveira, Rosana Antunes da, 1975-
Tipo de documento: Artigo
Título da fonte: Repositório da Produção Científica e Intelectual da Unicamp
Texto Completo: https://hdl.handle.net/20.500.12733/8775
Resumo: Agradecimentos: This study was supported in part by research funding from FAPESP (Fundac¸ao de Amparo a Pesquisa de Estado de São Paulo) (grants 03/12605-2R; 03/09054-4; and 05/59708-6) to KBP, from Fundac¸ao Maria Cecília de Souto Vidigal to IB, and from Novartis Argentina’ grants to RB. The authors would like to thank the data managers, physicians, and laboratory staff of the participant centers, in particular Luz Marina Majsa (from United States), Oscar Ballester (English review) and to doctors Riva ME; Lanari E; Milone J; Ventriglia V; Bullorsky E (for the contribution with their patients from Argentina); Anderson Tavares (Unicamp); Paola Cappelletti; and Simone Bonecker (INCA) (from Brazil).
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spelling BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survivalLeucemia mielóide crônicaImatinibeProteínas tirosina quinases - InibidoresChronic myeloid leukemiaImatinibeProtein-tyrosine kinase - InhibitorsBCR-ABL mutationsResistanceArtigo originalAgradecimentos: This study was supported in part by research funding from FAPESP (Fundac¸ao de Amparo a Pesquisa de Estado de São Paulo) (grants 03/12605-2R; 03/09054-4; and 05/59708-6) to KBP, from Fundac¸ao Maria Cecília de Souto Vidigal to IB, and from Novartis Argentina’ grants to RB. The authors would like to thank the data managers, physicians, and laboratory staff of the participant centers, in particular Luz Marina Majsa (from United States), Oscar Ballester (English review) and to doctors Riva ME; Lanari E; Milone J; Ventriglia V; Bullorsky E (for the contribution with their patients from Argentina); Anderson Tavares (Unicamp); Paola Cappelletti; and Simone Bonecker (INCA) (from Brazil).Abstract: This is the largest Latin American study of BCR-ABL mutations in chronic myeloid leukemia (CML) patients, resistant to imatinib (IM). In 195/467 (41%) patients, mutations were detected. The most frequent mutation was T315I (n = 31, 16%). Progression-free (PFS) and overall survival (OS) at 5 years were lower in patients with BCR-ABL mutations (43% vs. 65%, p = 0.07 and 47% vs. 72%, p = 0.03, respectively) and in those with the T315I mutation (p = 0.003 and p = 0.03). OS and PFS were superior in subgroup who switched to second generation inhibitors (SGIs) after IM failure (OS: 50% vs. 39% p = 0.01; PFS: 48% vs. 30% p = 0.02). BCR-ABL mutations conferred a significant poor prognosis in CML patientsFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPFechadoUNIVERSIDADE ESTADUAL DE CAMPINASPagnano, Katia Borgia BarbosaSouza, Carmino Antonio de, 1951-Miranda, Eliana Cristina Martins, 1965-Silveira, Rosana Antunes da, 1975-2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12733/8775PAGNANO, Katia Borgia Barbosa et al. BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival. Cancer Investigation. Philadelphia, PA : Taylor & Francis, 2015. Vol. 33, n. 9 (Aug., 2015), p. 451-458. Disponível em: https://hdl.handle.net/20.500.12733/8775. Acesso em: 24 mai. 2023.Inglêshttps://repositorio.unicamp.br/acervo/detalhe/1168660reponame:Repositório da Produção Científica e Intelectual da Unicampinstname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPinfo:eu-repo/semantics/openAccess2023-04-25T15:59:41Zoai:https://www.repositorio.unicamp.br/:1168660Repositório InstitucionalPUBhttp://repositorio.unicamp.br/oai/requestreposip@unicamp.bropendoar:2023-04-25T15:59:41Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)false
dc.title.none.fl_str_mv BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival
title BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival
spellingShingle BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival
Pagnano, Katia Borgia Barbosa
Leucemia mielóide crônica
Imatinibe
Proteínas tirosina quinases - Inibidores
Chronic myeloid leukemia
Imatinibe
Protein-tyrosine kinase - Inhibitors
BCR-ABL mutations
Resistance
Artigo original
title_short BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival
title_full BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival
title_fullStr BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival
title_full_unstemmed BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival
title_sort BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival
author Pagnano, Katia Borgia Barbosa
author_facet Pagnano, Katia Borgia Barbosa
Souza, Carmino Antonio de, 1951-
Miranda, Eliana Cristina Martins, 1965-
Silveira, Rosana Antunes da, 1975-
author_role author
author2 Souza, Carmino Antonio de, 1951-
Miranda, Eliana Cristina Martins, 1965-
Silveira, Rosana Antunes da, 1975-
author2_role author
author
author
dc.contributor.none.fl_str_mv UNIVERSIDADE ESTADUAL DE CAMPINAS
dc.contributor.author.fl_str_mv Pagnano, Katia Borgia Barbosa
Souza, Carmino Antonio de, 1951-
Miranda, Eliana Cristina Martins, 1965-
Silveira, Rosana Antunes da, 1975-
dc.subject.por.fl_str_mv Leucemia mielóide crônica
Imatinibe
Proteínas tirosina quinases - Inibidores
Chronic myeloid leukemia
Imatinibe
Protein-tyrosine kinase - Inhibitors
BCR-ABL mutations
Resistance
Artigo original
topic Leucemia mielóide crônica
Imatinibe
Proteínas tirosina quinases - Inibidores
Chronic myeloid leukemia
Imatinibe
Protein-tyrosine kinase - Inhibitors
BCR-ABL mutations
Resistance
Artigo original
description Agradecimentos: This study was supported in part by research funding from FAPESP (Fundac¸ao de Amparo a Pesquisa de Estado de São Paulo) (grants 03/12605-2R; 03/09054-4; and 05/59708-6) to KBP, from Fundac¸ao Maria Cecília de Souto Vidigal to IB, and from Novartis Argentina’ grants to RB. The authors would like to thank the data managers, physicians, and laboratory staff of the participant centers, in particular Luz Marina Majsa (from United States), Oscar Ballester (English review) and to doctors Riva ME; Lanari E; Milone J; Ventriglia V; Bullorsky E (for the contribution with their patients from Argentina); Anderson Tavares (Unicamp); Paola Cappelletti; and Simone Bonecker (INCA) (from Brazil).
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/20.500.12733/8775
PAGNANO, Katia Borgia Barbosa et al. BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival. Cancer Investigation. Philadelphia, PA : Taylor & Francis, 2015. Vol. 33, n. 9 (Aug., 2015), p. 451-458. Disponível em: https://hdl.handle.net/20.500.12733/8775. Acesso em: 24 mai. 2023.
url https://hdl.handle.net/20.500.12733/8775
identifier_str_mv PAGNANO, Katia Borgia Barbosa et al. BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival. Cancer Investigation. Philadelphia, PA : Taylor & Francis, 2015. Vol. 33, n. 9 (Aug., 2015), p. 451-458. Disponível em: https://hdl.handle.net/20.500.12733/8775. Acesso em: 24 mai. 2023.
dc.language.iso.fl_str_mv Inglês
language_invalid_str_mv Inglês
dc.relation.none.fl_str_mv https://repositorio.unicamp.br/acervo/detalhe/1168660
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório da Produção Científica e Intelectual da Unicamp
instname:Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP
instname_str Universidade Estadual de Campinas (UNICAMP)
instacron_str UNICAMP
institution UNICAMP
reponame_str Repositório da Produção Científica e Intelectual da Unicamp
collection Repositório da Produção Científica e Intelectual da Unicamp
repository.name.fl_str_mv Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)
repository.mail.fl_str_mv reposip@unicamp.br
_version_ 1766887291873132544

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