BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Título da fonte: | Repositório da Produção Científica e Intelectual da Unicamp |
Texto Completo: | https://hdl.handle.net/20.500.12733/8775 |
Resumo: | Agradecimentos: This study was supported in part by research funding from FAPESP (Fundac¸ao de Amparo a Pesquisa de Estado de São Paulo) (grants 03/12605-2R; 03/09054-4; and 05/59708-6) to KBP, from Fundac¸ao Maria Cecília de Souto Vidigal to IB, and from Novartis Argentina’ grants to RB. The authors would like to thank the data managers, physicians, and laboratory staff of the participant centers, in particular Luz Marina Majsa (from United States), Oscar Ballester (English review) and to doctors Riva ME; Lanari E; Milone J; Ventriglia V; Bullorsky E (for the contribution with their patients from Argentina); Anderson Tavares (Unicamp); Paola Cappelletti; and Simone Bonecker (INCA) (from Brazil). |
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BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survivalLeucemia mielóide crônicaImatinibeProteínas tirosina quinases - InibidoresChronic myeloid leukemiaImatinibeProtein-tyrosine kinase - InhibitorsBCR-ABL mutationsResistanceArtigo originalAgradecimentos: This study was supported in part by research funding from FAPESP (Fundac¸ao de Amparo a Pesquisa de Estado de São Paulo) (grants 03/12605-2R; 03/09054-4; and 05/59708-6) to KBP, from Fundac¸ao Maria Cecília de Souto Vidigal to IB, and from Novartis Argentina’ grants to RB. The authors would like to thank the data managers, physicians, and laboratory staff of the participant centers, in particular Luz Marina Majsa (from United States), Oscar Ballester (English review) and to doctors Riva ME; Lanari E; Milone J; Ventriglia V; Bullorsky E (for the contribution with their patients from Argentina); Anderson Tavares (Unicamp); Paola Cappelletti; and Simone Bonecker (INCA) (from Brazil).Abstract: This is the largest Latin American study of BCR-ABL mutations in chronic myeloid leukemia (CML) patients, resistant to imatinib (IM). In 195/467 (41%) patients, mutations were detected. The most frequent mutation was T315I (n = 31, 16%). Progression-free (PFS) and overall survival (OS) at 5 years were lower in patients with BCR-ABL mutations (43% vs. 65%, p = 0.07 and 47% vs. 72%, p = 0.03, respectively) and in those with the T315I mutation (p = 0.003 and p = 0.03). OS and PFS were superior in subgroup who switched to second generation inhibitors (SGIs) after IM failure (OS: 50% vs. 39% p = 0.01; PFS: 48% vs. 30% p = 0.02). BCR-ABL mutations conferred a significant poor prognosis in CML patientsFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPFechadoUNIVERSIDADE ESTADUAL DE CAMPINASPagnano, Katia Borgia BarbosaSouza, Carmino Antonio de, 1951-Miranda, Eliana Cristina Martins, 1965-Silveira, Rosana Antunes da, 1975-2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12733/8775PAGNANO, Katia Borgia Barbosa et al. BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival. Cancer Investigation. Philadelphia, PA : Taylor & Francis, 2015. Vol. 33, n. 9 (Aug., 2015), p. 451-458. Disponível em: https://hdl.handle.net/20.500.12733/8775. Acesso em: 24 mai. 2023.Inglêshttps://repositorio.unicamp.br/acervo/detalhe/1168660reponame:Repositório da Produção Científica e Intelectual da Unicampinstname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPinfo:eu-repo/semantics/openAccess2023-04-25T15:59:41Zoai:https://www.repositorio.unicamp.br/:1168660Repositório InstitucionalPUBhttp://repositorio.unicamp.br/oai/requestreposip@unicamp.bropendoar:2023-04-25T15:59:41Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)false |
dc.title.none.fl_str_mv |
BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival |
title |
BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival |
spellingShingle |
BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival Pagnano, Katia Borgia Barbosa Leucemia mielóide crônica Imatinibe Proteínas tirosina quinases - Inibidores Chronic myeloid leukemia Imatinibe Protein-tyrosine kinase - Inhibitors BCR-ABL mutations Resistance Artigo original |
title_short |
BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival |
title_full |
BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival |
title_fullStr |
BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival |
title_full_unstemmed |
BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival |
title_sort |
BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival |
author |
Pagnano, Katia Borgia Barbosa |
author_facet |
Pagnano, Katia Borgia Barbosa Souza, Carmino Antonio de, 1951- Miranda, Eliana Cristina Martins, 1965- Silveira, Rosana Antunes da, 1975- |
author_role |
author |
author2 |
Souza, Carmino Antonio de, 1951- Miranda, Eliana Cristina Martins, 1965- Silveira, Rosana Antunes da, 1975- |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
UNIVERSIDADE ESTADUAL DE CAMPINAS |
dc.contributor.author.fl_str_mv |
Pagnano, Katia Borgia Barbosa Souza, Carmino Antonio de, 1951- Miranda, Eliana Cristina Martins, 1965- Silveira, Rosana Antunes da, 1975- |
dc.subject.por.fl_str_mv |
Leucemia mielóide crônica Imatinibe Proteínas tirosina quinases - Inibidores Chronic myeloid leukemia Imatinibe Protein-tyrosine kinase - Inhibitors BCR-ABL mutations Resistance Artigo original |
topic |
Leucemia mielóide crônica Imatinibe Proteínas tirosina quinases - Inibidores Chronic myeloid leukemia Imatinibe Protein-tyrosine kinase - Inhibitors BCR-ABL mutations Resistance Artigo original |
description |
Agradecimentos: This study was supported in part by research funding from FAPESP (Fundac¸ao de Amparo a Pesquisa de Estado de São Paulo) (grants 03/12605-2R; 03/09054-4; and 05/59708-6) to KBP, from Fundac¸ao Maria Cecília de Souto Vidigal to IB, and from Novartis Argentina’ grants to RB. The authors would like to thank the data managers, physicians, and laboratory staff of the participant centers, in particular Luz Marina Majsa (from United States), Oscar Ballester (English review) and to doctors Riva ME; Lanari E; Milone J; Ventriglia V; Bullorsky E (for the contribution with their patients from Argentina); Anderson Tavares (Unicamp); Paola Cappelletti; and Simone Bonecker (INCA) (from Brazil). |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/20.500.12733/8775 PAGNANO, Katia Borgia Barbosa et al. BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival. Cancer Investigation. Philadelphia, PA : Taylor & Francis, 2015. Vol. 33, n. 9 (Aug., 2015), p. 451-458. Disponível em: https://hdl.handle.net/20.500.12733/8775. Acesso em: 24 mai. 2023. |
url |
https://hdl.handle.net/20.500.12733/8775 |
identifier_str_mv |
PAGNANO, Katia Borgia Barbosa et al. BCR-ABL mutations in chronic myeloid leukemia treated with tyrosine kinase inhibitors and impact on survival. Cancer Investigation. Philadelphia, PA : Taylor & Francis, 2015. Vol. 33, n. 9 (Aug., 2015), p. 451-458. Disponível em: https://hdl.handle.net/20.500.12733/8775. Acesso em: 24 mai. 2023. |
dc.language.iso.fl_str_mv |
Inglês |
language_invalid_str_mv |
Inglês |
dc.relation.none.fl_str_mv |
https://repositorio.unicamp.br/acervo/detalhe/1168660 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório da Produção Científica e Intelectual da Unicamp instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
instname_str |
Universidade Estadual de Campinas (UNICAMP) |
instacron_str |
UNICAMP |
institution |
UNICAMP |
reponame_str |
Repositório da Produção Científica e Intelectual da Unicamp |
collection |
Repositório da Produção Científica e Intelectual da Unicamp |
repository.name.fl_str_mv |
Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP) |
repository.mail.fl_str_mv |
reposip@unicamp.br |
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1766887291873132544 |