INFLUENCE OF HYDROETHANOLIC EXTRACT FROM THE LEAVES OF Tropaeolum majus FOR TISSUE RESTORATION OF SKIN LESIONS

Detalhes bibliográficos
Autor(a) principal: Correa, Jéssica Santos
Data de Publicação: 2016
Outros Autores: Monteiro, Edylaine Aparecida, Pavanelli, Mariana Felgueira, Biazon, Ana Carla Broetto
Tipo de documento: Artigo
Idioma: por
Título da fonte: Saúde e Pesquisa (Online)
Texto Completo: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/4942
Resumo: The healing activity of the hydroethanolic extract of Tropaeolum majus leaves on rats´ skin lesions is provided. Fifteen Wistar rats were used, distributed in three groups, G7, G14 and G21, according to observation period 7, 14 and 21 days after surgery. Two wounds, diameter 1 cm, on the dorsal region of each animal, were treated with Carbopol gel on the left side and by Tropaeolum majus on the right side. Lesions were treated daily during the periods above. A comparative study was undertaken between the two groups by micro- and macroscopy. The formation of a wound scab on all wounds up to the seventh day was observed. Histological assessment revealed that lesions treated with Tropaeolum majus extract had a lower inflammatory infiltrate rate and fibroblastic proliferation when compared to lesions treated with gel, coupled to a greater collagenization and deeper angiogenesis on the 7th, 14th and 21st day after surgery. Results showed that hydroethanolic extract of Tropaeolum majus leaves caused a better improvement in the healing process through the increase in the formation of neo-vases and collagenization.
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spelling INFLUENCE OF HYDROETHANOLIC EXTRACT FROM THE LEAVES OF Tropaeolum majus FOR TISSUE RESTORATION OF SKIN LESIONSInfluência do Extrato Hidroetanólico das Folhas de Tropaeolum majus na Restauração Tecidual em Lesões CutâneasWound HealingMedicinal PlantsTropaeolum majus.Wound HealingMedicinal PlantsTropaeolum majus.CicatrizaçãoPlantas MedicinaisTropaeolum majus.CicatrizaçãoPlantas MedicinaisTropaeolum majus.The healing activity of the hydroethanolic extract of Tropaeolum majus leaves on rats´ skin lesions is provided. Fifteen Wistar rats were used, distributed in three groups, G7, G14 and G21, according to observation period 7, 14 and 21 days after surgery. Two wounds, diameter 1 cm, on the dorsal region of each animal, were treated with Carbopol gel on the left side and by Tropaeolum majus on the right side. Lesions were treated daily during the periods above. A comparative study was undertaken between the two groups by micro- and macroscopy. The formation of a wound scab on all wounds up to the seventh day was observed. Histological assessment revealed that lesions treated with Tropaeolum majus extract had a lower inflammatory infiltrate rate and fibroblastic proliferation when compared to lesions treated with gel, coupled to a greater collagenization and deeper angiogenesis on the 7th, 14th and 21st day after surgery. Results showed that hydroethanolic extract of Tropaeolum majus leaves caused a better improvement in the healing process through the increase in the formation of neo-vases and collagenization.O presente estudo teve como objetivo avaliar a ação cicatrizante do extrato hidroetanólico de folhas de Tropaeolum majus em lesões cutâneas em ratos. Para isso foram utilizados 15 ratos Wistar distribuídos em 3 grupos denominados de G7, G14 e G21, de acordo com o período de observação em 7, 14 e 21 dias após o procedimento cirúrgico. Na região dorsal de cada animal foram realizadas duas feridas de 1 cm de diâmetro, sendo a da esquerda tratada com gel base de Carbopol, e a da direita com gel de Tropaeolum majus. Os tratamentos nas lesões ocorreram diariamente nos períodos citados. Realizou-se estudo comparativo entre os dois grupos por meio da análise micro e macroscópica. Observou-se formação de crosta em todas as feridas até o sétimo dia. Na avaliação histológica, as lesões tratadas com o extrato de Tropaeolum majus apresentaram uma menor quantidade de infiltrado inflamatório e de proliferação fibloblástica com relação às lesões tratadas com o gel base e uma maior colageneização bem como mais acentuada angiogênese no 7º, 14º e 21º dia do pós-operatório. Conclui-se que o extrato hidroetanólico de folhas de Tropaeolum majus promoveu melhora do processo de cicatrização por aumento da formação de neovasos e colageneização.Universidade Cesumar - UniCesumar2016-06-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por ParesPesquisaapplication/pdfhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/494210.17765/1983-1870.2016v9n1p101-109Saúde e Pesquisa; Vol 9 No 1 (2016): jan./abr.; 101-109Saúde e Pesquisa; v. 9 n. 1 (2016): jan./abr.; 101-1092176-9206reponame:Saúde e Pesquisa (Online)instname:Cesumar Diretoria de Pesquisainstacron:CESUMARporhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/4942/2754Correa, Jéssica SantosMonteiro, Edylaine AparecidaPavanelli, Mariana FelgueiraBiazon, Ana Carla Broettoinfo:eu-repo/semantics/openAccess2021-12-07T20:06:26Zoai:ojs.pkp.sfu.ca:article/4942Revistahttps://periodicos.unicesumar.edu.br/index.php/saudpesqPUBhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/oainaep@cesumar.br2176-92061983-1870opendoar:2021-12-07T20:06:26Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisafalse
dc.title.none.fl_str_mv INFLUENCE OF HYDROETHANOLIC EXTRACT FROM THE LEAVES OF Tropaeolum majus FOR TISSUE RESTORATION OF SKIN LESIONS
Influência do Extrato Hidroetanólico das Folhas de Tropaeolum majus na Restauração Tecidual em Lesões Cutâneas
title INFLUENCE OF HYDROETHANOLIC EXTRACT FROM THE LEAVES OF Tropaeolum majus FOR TISSUE RESTORATION OF SKIN LESIONS
spellingShingle INFLUENCE OF HYDROETHANOLIC EXTRACT FROM THE LEAVES OF Tropaeolum majus FOR TISSUE RESTORATION OF SKIN LESIONS
Correa, Jéssica Santos
Wound Healing
Medicinal Plants
Tropaeolum majus.
Wound Healing
Medicinal Plants
Tropaeolum majus.
Cicatrização
Plantas Medicinais
Tropaeolum majus.
Cicatrização
Plantas Medicinais
Tropaeolum majus.
title_short INFLUENCE OF HYDROETHANOLIC EXTRACT FROM THE LEAVES OF Tropaeolum majus FOR TISSUE RESTORATION OF SKIN LESIONS
title_full INFLUENCE OF HYDROETHANOLIC EXTRACT FROM THE LEAVES OF Tropaeolum majus FOR TISSUE RESTORATION OF SKIN LESIONS
title_fullStr INFLUENCE OF HYDROETHANOLIC EXTRACT FROM THE LEAVES OF Tropaeolum majus FOR TISSUE RESTORATION OF SKIN LESIONS
title_full_unstemmed INFLUENCE OF HYDROETHANOLIC EXTRACT FROM THE LEAVES OF Tropaeolum majus FOR TISSUE RESTORATION OF SKIN LESIONS
title_sort INFLUENCE OF HYDROETHANOLIC EXTRACT FROM THE LEAVES OF Tropaeolum majus FOR TISSUE RESTORATION OF SKIN LESIONS
author Correa, Jéssica Santos
author_facet Correa, Jéssica Santos
Monteiro, Edylaine Aparecida
Pavanelli, Mariana Felgueira
Biazon, Ana Carla Broetto
author_role author
author2 Monteiro, Edylaine Aparecida
Pavanelli, Mariana Felgueira
Biazon, Ana Carla Broetto
author2_role author
author
author
dc.contributor.author.fl_str_mv Correa, Jéssica Santos
Monteiro, Edylaine Aparecida
Pavanelli, Mariana Felgueira
Biazon, Ana Carla Broetto
dc.subject.por.fl_str_mv Wound Healing
Medicinal Plants
Tropaeolum majus.
Wound Healing
Medicinal Plants
Tropaeolum majus.
Cicatrização
Plantas Medicinais
Tropaeolum majus.
Cicatrização
Plantas Medicinais
Tropaeolum majus.
topic Wound Healing
Medicinal Plants
Tropaeolum majus.
Wound Healing
Medicinal Plants
Tropaeolum majus.
Cicatrização
Plantas Medicinais
Tropaeolum majus.
Cicatrização
Plantas Medicinais
Tropaeolum majus.
description The healing activity of the hydroethanolic extract of Tropaeolum majus leaves on rats´ skin lesions is provided. Fifteen Wistar rats were used, distributed in three groups, G7, G14 and G21, according to observation period 7, 14 and 21 days after surgery. Two wounds, diameter 1 cm, on the dorsal region of each animal, were treated with Carbopol gel on the left side and by Tropaeolum majus on the right side. Lesions were treated daily during the periods above. A comparative study was undertaken between the two groups by micro- and macroscopy. The formation of a wound scab on all wounds up to the seventh day was observed. Histological assessment revealed that lesions treated with Tropaeolum majus extract had a lower inflammatory infiltrate rate and fibroblastic proliferation when compared to lesions treated with gel, coupled to a greater collagenization and deeper angiogenesis on the 7th, 14th and 21st day after surgery. Results showed that hydroethanolic extract of Tropaeolum majus leaves caused a better improvement in the healing process through the increase in the formation of neo-vases and collagenization.
publishDate 2016
dc.date.none.fl_str_mv 2016-06-14
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado por Pares
Pesquisa
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/4942
10.17765/1983-1870.2016v9n1p101-109
url https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/4942
identifier_str_mv 10.17765/1983-1870.2016v9n1p101-109
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/4942/2754
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Cesumar - UniCesumar
publisher.none.fl_str_mv Universidade Cesumar - UniCesumar
dc.source.none.fl_str_mv Saúde e Pesquisa; Vol 9 No 1 (2016): jan./abr.; 101-109
Saúde e Pesquisa; v. 9 n. 1 (2016): jan./abr.; 101-109
2176-9206
reponame:Saúde e Pesquisa (Online)
instname:Cesumar Diretoria de Pesquisa
instacron:CESUMAR
instname_str Cesumar Diretoria de Pesquisa
instacron_str CESUMAR
institution CESUMAR
reponame_str Saúde e Pesquisa (Online)
collection Saúde e Pesquisa (Online)
repository.name.fl_str_mv Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisa
repository.mail.fl_str_mv naep@cesumar.br
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