Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7529 |
Resumo: | Case Western Reserve University. Center for Global Health and Diseases. Cleveland, OH, USA |
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Blanton, Ronald EdwardSilva, Luciano KalabricMorato, Vanessa G.Parrado, Antonio R.Dias, Juarez PereiraMelo, Paulo Roberto Santana deReis, Eliana Almeida GomesGoddard, Katrina A. B.Nunes, Márcio R. T.Rodrigues, Sueli G.Vasconcelos, Pedro F. C.Castro, Jesuina M.Reis, Mitermayer Galvão dosBarreto, Maurício LimaTeixeira, Maria da Glória2014-04-23T14:29:45Z2014-04-23T14:29:45Z2008BLANTON, R. E. et al. Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. European Journal of Human Genetics, v. 16, n. 6, p. 762-765, 2008.1018-4813https://www.arca.fiocruz.br/handle/icict/752910.1038/ejhg.2008.4engNature Publishing GroupGenetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCase Western Reserve University. Center for Global Health and Diseases. Cleveland, OH, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilUniversidade Federal da Bahia. Institute of Collective Health. Salvador, BA, BrasilCase Western Reserve University. Division of Genetic Epidemiology. Department of Epidemiology & Biostatistics Wolstein Research Building. Cleveland, OH, USASecretaria da Saúde do Estado da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilCase Western Reserve University. Division of Genetic Epidemiology. Department of Epidemiology & Biostatistics Wolstein Research Building. Cleveland, OH, USAInstituto Evandro Chagas. Department of Arbovirology and Hemorrhagic Fever. Belém, PA, BrasilInstituto Evandro Chagas. Department of Arbovirology and Hemorrhagic Fever. Belém, PA, BrasilInstituto Evandro Chagas. Department of Arbovirology and Hemorrhagic Fever. Belém, PA, BrasilSecretaria da Saúde do Estado da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilUniversidade Federal da Bahia. Institute of Collective Health. Salvador, BA, BrasilUniversidade Federal da Bahia. Institute of Collective Health. Salvador, BA, BrasilTo test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P¼0.02, OR¼0.28 and P¼0.02, OR¼0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.EthnicityRacePopulation structureSocioeconomic statusDENV3Dengue/genéticaRendaGrupo com Ancestrais do Continente Africano/genéticaBrasilGenótipoHumanosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBlanton R Genetic ancestry....pdfBlanton R Genetic ancestry....pdfapplication/pdf115239https://www.arca.fiocruz.br/bitstream/icict/7529/1/Blanton%20R%20Genetic%20ancestry....pdf910b1e8af0e8f506e9776e1c78ae926bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7529/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBlanton R Genetic ancestry....pdf.txtBlanton R Genetic ancestry....pdf.txtExtracted texttext/plain15732https://www.arca.fiocruz.br/bitstream/icict/7529/5/Blanton%20R%20Genetic%20ancestry....pdf.txt525f770cfb325dcea51a78ae7677a184MD55THUMBNAILBlanton R Genetic ancestry....pdf.jpgBlanton R Genetic ancestry....pdf.jpgGenerated Thumbnailimage/jpeg2409https://www.arca.fiocruz.br/bitstream/icict/7529/4/Blanton%20R%20Genetic%20ancestry....pdf.jpg71f54b381273ac2a402662b25d3f8c6dMD54icict/75292023-03-15 14:33:17.06oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. |
| title |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. |
| spellingShingle |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. Blanton, Ronald Edward Ethnicity Race Population structure Socioeconomic status DENV3 Dengue/genética Renda Grupo com Ancestrais do Continente Africano/genética Brasil Genótipo Humanos |
| title_short |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. |
| title_full |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. |
| title_fullStr |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. |
| title_full_unstemmed |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. |
| title_sort |
Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. |
| author |
Blanton, Ronald Edward |
| author_facet |
Blanton, Ronald Edward Silva, Luciano Kalabric Morato, Vanessa G. Parrado, Antonio R. Dias, Juarez Pereira Melo, Paulo Roberto Santana de Reis, Eliana Almeida Gomes Goddard, Katrina A. B. Nunes, Márcio R. T. Rodrigues, Sueli G. Vasconcelos, Pedro F. C. Castro, Jesuina M. Reis, Mitermayer Galvão dos Barreto, Maurício Lima Teixeira, Maria da Glória |
| author_role |
author |
| author2 |
Silva, Luciano Kalabric Morato, Vanessa G. Parrado, Antonio R. Dias, Juarez Pereira Melo, Paulo Roberto Santana de Reis, Eliana Almeida Gomes Goddard, Katrina A. B. Nunes, Márcio R. T. Rodrigues, Sueli G. Vasconcelos, Pedro F. C. Castro, Jesuina M. Reis, Mitermayer Galvão dos Barreto, Maurício Lima Teixeira, Maria da Glória |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Blanton, Ronald Edward Silva, Luciano Kalabric Morato, Vanessa G. Parrado, Antonio R. Dias, Juarez Pereira Melo, Paulo Roberto Santana de Reis, Eliana Almeida Gomes Goddard, Katrina A. B. Nunes, Márcio R. T. Rodrigues, Sueli G. Vasconcelos, Pedro F. C. Castro, Jesuina M. Reis, Mitermayer Galvão dos Barreto, Maurício Lima Teixeira, Maria da Glória |
| dc.subject.en.pt_BR.fl_str_mv |
Ethnicity Race Population structure Socioeconomic status DENV3 |
| topic |
Ethnicity Race Population structure Socioeconomic status DENV3 Dengue/genética Renda Grupo com Ancestrais do Continente Africano/genética Brasil Genótipo Humanos |
| dc.subject.decs.pt_BR.fl_str_mv |
Dengue/genética Renda Grupo com Ancestrais do Continente Africano/genética Brasil Genótipo Humanos |
| description |
Case Western Reserve University. Center for Global Health and Diseases. Cleveland, OH, USA |
| publishDate |
2008 |
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2008 |
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2014-04-23T14:29:45Z |
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2014-04-23T14:29:45Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BLANTON, R. E. et al. Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. European Journal of Human Genetics, v. 16, n. 6, p. 762-765, 2008. |
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https://www.arca.fiocruz.br/handle/icict/7529 |
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1018-4813 |
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10.1038/ejhg.2008.4 |
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BLANTON, R. E. et al. Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. European Journal of Human Genetics, v. 16, n. 6, p. 762-765, 2008. 1018-4813 10.1038/ejhg.2008.4 |
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Nature Publishing Group |
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