An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets

Detalhes bibliográficos
Autor(a) principal: Ramos, Pablo Ivan Pereira
Data de Publicação: 2018
Outros Autores: Fernández do Porto, Darío, Lanzarotti, Esteban, Sosa, Ezequiel J, Burguener, Germán, Pardo, Agustín M, Klein, Cecilia C, Sagot, Marie-France, Vasconcelos, Ana Tereza Ribeiro de, Gales, Ana Cristina, Marti, Marcelo, Turjanski, Adrián G, Nicolás, Marisa Fabiana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28354
Resumo: Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ/ CONICET, process no. E-26/110.315/2014) and from CNPq (process no. 307713/2016-4). ES, DFDP, AGT and MM are members of CONICET. M-FS and CCK acknowledge funding from the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. [247073]10. ATRV acknowledges funding from CNPq (process 302.768/2011-4), FAPERJ (process E-26/202.903/2015) and CAPES (process 23038.010041/2013-13).
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spelling Ramos, Pablo Ivan PereiraFernández do Porto, DaríoLanzarotti, EstebanSosa, Ezequiel JBurguener, GermánPardo, Agustín MKlein, Cecilia CSagot, Marie-FranceVasconcelos, Ana Tereza Ribeiro deGales, Ana CristinaMarti, MarceloTurjanski, Adrián GNicolás, Marisa Fabiana2018-08-24T16:20:54Z2018-08-24T16:20:54Z2018RAMOS, P. I. P. et al. An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets. Scientific Reports, v. 8, p. 10755, 2018.2045-2322https://www.arca.fiocruz.br/handle/icict/2835410.1038/s41598-018-28916-7Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ/ CONICET, process no. E-26/110.315/2014) and from CNPq (process no. 307713/2016-4). ES, DFDP, AGT and MM are members of CONICET. M-FS and CCK acknowledge funding from the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. [247073]10. ATRV acknowledges funding from CNPq (process 302.768/2011-4), FAPERJ (process E-26/202.903/2015) and CAPES (process 23038.010041/2013-13).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Laboratório Nacional de Computação Científica. Petrópolis, RJ, BrasilUniversidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Cálculo. Plataforma de Bioinformática Argentina. Buenos Aires, Argentina / Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Ciudad de Buenos Aires, ArgentinaFacultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la. Ciudad de Buenos Aires, ArgentinaUniversidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Cálculo. Plataforma de Bioinformática Argentina. Buenos Aires, ArgentinaUniversidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Cálculo. Plataforma de Bioinformática Argentina. Buenos Aires, ArgentinaFacultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la. Ciudad de Buenos Aires, ArgentinaInria Grenoble Rhône-Alpes. Grenoble, France / Université Claude Bernard. Lyon, France / Universitat de Barcelona. Facultat de Biologia and Institut de Biomedicina. Centre for Genomic Regulation. Departament de Genètica, Microbiologia i Estadística. Barcelona, Catalonia, SpainInria Grenoble Rhône-Alpes. Grenoble, France / Université Claude Bernard. Lyon, FranceLaboratório Nacional de Computação Científica. Petrópolis, RJ, BrasilUniversidade Federal de São Paulo. Escola Paulista de Medicina. Division of Infectious Diseases. Department of Internal Medicine. Laboratório Alerta. São Paulo, SP, BrasilUniversidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Cálculo. Plataforma de Bioinformática Argentina. Buenos Aires, Argentina / Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Ciudad de Buenos Aires, Argentina / Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la. Ciudad de Buenos Aires, ArgentinaUniversidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Cálculo. Plataforma de Bioinformática Argentina. Buenos Aires, Argentina / Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Ciudad de Buenos Aires, Argentina / Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la. Ciudad de Buenos Aires, ArgentinaLaboratório Nacional de Computação Científica. Petrópolis, RJ, BrasilKlebsiella pneumoniae (Kp) is a globally disseminated opportunistic pathogen that can cause life-threatening infections. It has been found as the culprit of many infection outbreaks in hospital environments, being particularly aggressive towards newborns and adults under intensive care. Many Kp strains produce extended-spectrum β-lactamases, enzymes that promote resistance against antibiotics used to fight these infections. The presence of other resistance determinants leading to multidrug-resistance also limit therapeutic options, and the use of 'last-resort' drugs, such as polymyxins, is not uncommon. The global emergence and spread of resistant strains underline the need for novel antimicrobials against Kp and related bacterial pathogens. To tackle this great challenge, we generated multiple layers of 'omics' data related to Kp and prioritized proteins that could serve as attractive targets for antimicrobial development. Genomics, transcriptomics, structuromic and metabolic information were integrated in order to prioritize candidate targets, and this data compendium is freely available as a web server. Twenty-nine proteins with desirable characteristics from a drug development perspective were shortlisted, which participate in important processes such as lipid synthesis, cofactor production, and core metabolism. Collectively, our results point towards novel targets for the control of Kp and related bacterial pathogens.engNature Publishing GroupKlebsiella pneumoniaeFatores de riscoInfecçãoHumanosResistência a antibióticosPatógenosKlebsiella pneumoniaeRisk FactorsInfectionHumansAntibiotic resistancePathogensAn integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targetsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28354/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRamos PI An integrative, multi-omics approach towards .....pdfRamos PI An integrative, multi-omics approach towards 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dc.title.pt_BR.fl_str_mv An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets
title An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets
spellingShingle An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets
Ramos, Pablo Ivan Pereira
Klebsiella pneumoniae
Fatores de risco
Infecção
Humanos
Resistência a antibióticos
Patógenos
Klebsiella pneumoniae
Risk Factors
Infection
Humans
Antibiotic resistance
Pathogens
title_short An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets
title_full An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets
title_fullStr An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets
title_full_unstemmed An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets
title_sort An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets
author Ramos, Pablo Ivan Pereira
author_facet Ramos, Pablo Ivan Pereira
Fernández do Porto, Darío
Lanzarotti, Esteban
Sosa, Ezequiel J
Burguener, Germán
Pardo, Agustín M
Klein, Cecilia C
Sagot, Marie-France
Vasconcelos, Ana Tereza Ribeiro de
Gales, Ana Cristina
Marti, Marcelo
Turjanski, Adrián G
Nicolás, Marisa Fabiana
author_role author
author2 Fernández do Porto, Darío
Lanzarotti, Esteban
Sosa, Ezequiel J
Burguener, Germán
Pardo, Agustín M
Klein, Cecilia C
Sagot, Marie-France
Vasconcelos, Ana Tereza Ribeiro de
Gales, Ana Cristina
Marti, Marcelo
Turjanski, Adrián G
Nicolás, Marisa Fabiana
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ramos, Pablo Ivan Pereira
Fernández do Porto, Darío
Lanzarotti, Esteban
Sosa, Ezequiel J
Burguener, Germán
Pardo, Agustín M
Klein, Cecilia C
Sagot, Marie-France
Vasconcelos, Ana Tereza Ribeiro de
Gales, Ana Cristina
Marti, Marcelo
Turjanski, Adrián G
Nicolás, Marisa Fabiana
dc.subject.other.pt_BR.fl_str_mv Klebsiella pneumoniae
Fatores de risco
Infecção
Humanos
Resistência a antibióticos
Patógenos
topic Klebsiella pneumoniae
Fatores de risco
Infecção
Humanos
Resistência a antibióticos
Patógenos
Klebsiella pneumoniae
Risk Factors
Infection
Humans
Antibiotic resistance
Pathogens
dc.subject.en.pt_BR.fl_str_mv Klebsiella pneumoniae
Risk Factors
Infection
Humans
Antibiotic resistance
Pathogens
description Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ/ CONICET, process no. E-26/110.315/2014) and from CNPq (process no. 307713/2016-4). ES, DFDP, AGT and MM are members of CONICET. M-FS and CCK acknowledge funding from the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. [247073]10. ATRV acknowledges funding from CNPq (process 302.768/2011-4), FAPERJ (process E-26/202.903/2015) and CAPES (process 23038.010041/2013-13).
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-08-24T16:20:54Z
dc.date.available.fl_str_mv 2018-08-24T16:20:54Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv RAMOS, P. I. P. et al. An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets. Scientific Reports, v. 8, p. 10755, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28354
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-018-28916-7
identifier_str_mv RAMOS, P. I. P. et al. An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets. Scientific Reports, v. 8, p. 10755, 2018.
2045-2322
10.1038/s41598-018-28916-7
url https://www.arca.fiocruz.br/handle/icict/28354
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
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