An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28354 |
Resumo: | Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ/ CONICET, process no. E-26/110.315/2014) and from CNPq (process no. 307713/2016-4). ES, DFDP, AGT and MM are members of CONICET. M-FS and CCK acknowledge funding from the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. [247073]10. ATRV acknowledges funding from CNPq (process 302.768/2011-4), FAPERJ (process E-26/202.903/2015) and CAPES (process 23038.010041/2013-13). |
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Ramos, Pablo Ivan PereiraFernández do Porto, DaríoLanzarotti, EstebanSosa, Ezequiel JBurguener, GermánPardo, Agustín MKlein, Cecilia CSagot, Marie-FranceVasconcelos, Ana Tereza Ribeiro deGales, Ana CristinaMarti, MarceloTurjanski, Adrián GNicolás, Marisa Fabiana2018-08-24T16:20:54Z2018-08-24T16:20:54Z2018RAMOS, P. I. P. et al. An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets. Scientific Reports, v. 8, p. 10755, 2018.2045-2322https://www.arca.fiocruz.br/handle/icict/2835410.1038/s41598-018-28916-7Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ/ CONICET, process no. E-26/110.315/2014) and from CNPq (process no. 307713/2016-4). ES, DFDP, AGT and MM are members of CONICET. M-FS and CCK acknowledge funding from the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. [247073]10. ATRV acknowledges funding from CNPq (process 302.768/2011-4), FAPERJ (process E-26/202.903/2015) and CAPES (process 23038.010041/2013-13).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Laboratório Nacional de Computação Científica. Petrópolis, RJ, BrasilUniversidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Cálculo. Plataforma de Bioinformática Argentina. Buenos Aires, Argentina / Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Ciudad de Buenos Aires, ArgentinaFacultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la. Ciudad de Buenos Aires, ArgentinaUniversidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Cálculo. Plataforma de Bioinformática Argentina. Buenos Aires, ArgentinaUniversidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Cálculo. Plataforma de Bioinformática Argentina. Buenos Aires, ArgentinaFacultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la. Ciudad de Buenos Aires, ArgentinaInria Grenoble Rhône-Alpes. Grenoble, France / Université Claude Bernard. Lyon, France / Universitat de Barcelona. Facultat de Biologia and Institut de Biomedicina. Centre for Genomic Regulation. Departament de Genètica, Microbiologia i Estadística. Barcelona, Catalonia, SpainInria Grenoble Rhône-Alpes. Grenoble, France / Université Claude Bernard. Lyon, FranceLaboratório Nacional de Computação Científica. Petrópolis, RJ, BrasilUniversidade Federal de São Paulo. Escola Paulista de Medicina. Division of Infectious Diseases. Department of Internal Medicine. Laboratório Alerta. São Paulo, SP, BrasilUniversidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Cálculo. Plataforma de Bioinformática Argentina. Buenos Aires, Argentina / Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Ciudad de Buenos Aires, Argentina / Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la. Ciudad de Buenos Aires, ArgentinaUniversidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Cálculo. Plataforma de Bioinformática Argentina. Buenos Aires, Argentina / Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Ciudad de Buenos Aires, Argentina / Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la. Ciudad de Buenos Aires, ArgentinaLaboratório Nacional de Computação Científica. Petrópolis, RJ, BrasilKlebsiella pneumoniae (Kp) is a globally disseminated opportunistic pathogen that can cause life-threatening infections. It has been found as the culprit of many infection outbreaks in hospital environments, being particularly aggressive towards newborns and adults under intensive care. Many Kp strains produce extended-spectrum β-lactamases, enzymes that promote resistance against antibiotics used to fight these infections. The presence of other resistance determinants leading to multidrug-resistance also limit therapeutic options, and the use of 'last-resort' drugs, such as polymyxins, is not uncommon. The global emergence and spread of resistant strains underline the need for novel antimicrobials against Kp and related bacterial pathogens. To tackle this great challenge, we generated multiple layers of 'omics' data related to Kp and prioritized proteins that could serve as attractive targets for antimicrobial development. Genomics, transcriptomics, structuromic and metabolic information were integrated in order to prioritize candidate targets, and this data compendium is freely available as a web server. Twenty-nine proteins with desirable characteristics from a drug development perspective were shortlisted, which participate in important processes such as lipid synthesis, cofactor production, and core metabolism. Collectively, our results point towards novel targets for the control of Kp and related bacterial pathogens.engNature Publishing GroupKlebsiella pneumoniaeFatores de riscoInfecçãoHumanosResistência a antibióticosPatógenosKlebsiella pneumoniaeRisk FactorsInfectionHumansAntibiotic resistancePathogensAn integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targetsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28354/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRamos PI An integrative, multi-omics approach towards .....pdfRamos PI An integrative, multi-omics approach towards 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dc.title.pt_BR.fl_str_mv |
An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets |
title |
An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets |
spellingShingle |
An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets Ramos, Pablo Ivan Pereira Klebsiella pneumoniae Fatores de risco Infecção Humanos Resistência a antibióticos Patógenos Klebsiella pneumoniae Risk Factors Infection Humans Antibiotic resistance Pathogens |
title_short |
An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets |
title_full |
An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets |
title_fullStr |
An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets |
title_full_unstemmed |
An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets |
title_sort |
An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets |
author |
Ramos, Pablo Ivan Pereira |
author_facet |
Ramos, Pablo Ivan Pereira Fernández do Porto, Darío Lanzarotti, Esteban Sosa, Ezequiel J Burguener, Germán Pardo, Agustín M Klein, Cecilia C Sagot, Marie-France Vasconcelos, Ana Tereza Ribeiro de Gales, Ana Cristina Marti, Marcelo Turjanski, Adrián G Nicolás, Marisa Fabiana |
author_role |
author |
author2 |
Fernández do Porto, Darío Lanzarotti, Esteban Sosa, Ezequiel J Burguener, Germán Pardo, Agustín M Klein, Cecilia C Sagot, Marie-France Vasconcelos, Ana Tereza Ribeiro de Gales, Ana Cristina Marti, Marcelo Turjanski, Adrián G Nicolás, Marisa Fabiana |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ramos, Pablo Ivan Pereira Fernández do Porto, Darío Lanzarotti, Esteban Sosa, Ezequiel J Burguener, Germán Pardo, Agustín M Klein, Cecilia C Sagot, Marie-France Vasconcelos, Ana Tereza Ribeiro de Gales, Ana Cristina Marti, Marcelo Turjanski, Adrián G Nicolás, Marisa Fabiana |
dc.subject.other.pt_BR.fl_str_mv |
Klebsiella pneumoniae Fatores de risco Infecção Humanos Resistência a antibióticos Patógenos |
topic |
Klebsiella pneumoniae Fatores de risco Infecção Humanos Resistência a antibióticos Patógenos Klebsiella pneumoniae Risk Factors Infection Humans Antibiotic resistance Pathogens |
dc.subject.en.pt_BR.fl_str_mv |
Klebsiella pneumoniae Risk Factors Infection Humans Antibiotic resistance Pathogens |
description |
Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ/ CONICET, process no. E-26/110.315/2014) and from CNPq (process no. 307713/2016-4). ES, DFDP, AGT and MM are members of CONICET. M-FS and CCK acknowledge funding from the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. [247073]10. ATRV acknowledges funding from CNPq (process 302.768/2011-4), FAPERJ (process E-26/202.903/2015) and CAPES (process 23038.010041/2013-13). |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-08-24T16:20:54Z |
dc.date.available.fl_str_mv |
2018-08-24T16:20:54Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
RAMOS, P. I. P. et al. An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets. Scientific Reports, v. 8, p. 10755, 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/28354 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-018-28916-7 |
identifier_str_mv |
RAMOS, P. I. P. et al. An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets. Scientific Reports, v. 8, p. 10755, 2018. 2045-2322 10.1038/s41598-018-28916-7 |
url |
https://www.arca.fiocruz.br/handle/icict/28354 |
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eng |
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eng |
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Nature Publishing Group |
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Nature Publishing Group |
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