Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection

Detalhes bibliográficos
Autor(a) principal: Fecury, Amanda Alves
Data de Publicação: 2014
Outros Autores: Almeida, Marcella Kelly Costa de, Santos, Kemper Nunes dos, Freitas, Andrei da Silva, Dantas Socorro de Fátima Loureiro, Costa, Carlos Araújo da, Crescente, ângelo Barlleta, Sousa, Rita Catarina Medeiros de, Brito, Elza Baía de, Nassiri, Reza, Lampe, Elizabeth, MAartins, Luisa Caricio, Universidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9896
Resumo: Universidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.
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spelling Fecury, Amanda AlvesAlmeida, Marcella Kelly Costa deSantos, Kemper Nunes dosFreitas, Andrei da SilvaDantas Socorro de Fátima LoureiroCosta, Carlos Araújo daCrescente, ângelo BarlletaSousa, Rita Catarina Medeiros deBrito, Elza Baía deNassiri, RezaLampe, ElizabethMAartins, Luisa CaricioUniversidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.2015-04-06T17:18:22Z2015-04-06T17:18:22Z2014FECURY, A. A.; et al. Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis c infection. Sociedade Brasileira de Medicina Tropical. Revista, v.47, n.1, p. 90-92,2014.16789849https://www.arca.fiocruz.br/handle/icict/9896DOI:10.1590/0037-8682-0008-2012engSociedade Brasileira de Medicina TropicalAssociation between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.Universidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.Universidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.Universidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.Universidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.Universidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.Universidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.Universidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.Michigan State University. Institute of International Health. Michigan, USA.The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression. Methods: Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation. Results: Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis. Conclusions: HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction.HistopathologyGenotypeHepatitis C virusCiências BiológicasHepatite CGenótipoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALelizabeth_lampeetal_IOC_2014.pdfapplication/pdf687985https://www.arca.fiocruz.br/bitstream/icict/9896/1/elizabeth_lampeetal_IOC_2014.pdfad06942bd96a3507552526d1d9a5b42aMD51LICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/9896/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTelizabeth_lampeetal_IOC_2014.pdf.txtelizabeth_lampeetal_IOC_2014.pdf.txtExtracted texttext/plain12149https://www.arca.fiocruz.br/bitstream/icict/9896/3/elizabeth_lampeetal_IOC_2014.pdf.txtc9040875e6e5e79d91b0ca61d3e93d5dMD53icict/98962022-06-24 13:02:59.779oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:02:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
title Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
spellingShingle Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
Fecury, Amanda Alves
Histopathology
Genotype
Hepatitis C virus
Ciências Biológicas
Hepatite C
Genótipo
title_short Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
title_full Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
title_fullStr Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
title_full_unstemmed Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
title_sort Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
author Fecury, Amanda Alves
author_facet Fecury, Amanda Alves
Almeida, Marcella Kelly Costa de
Santos, Kemper Nunes dos
Freitas, Andrei da Silva
Dantas Socorro de Fátima Loureiro
Costa, Carlos Araújo da
Crescente, ângelo Barlleta
Sousa, Rita Catarina Medeiros de
Brito, Elza Baía de
Nassiri, Reza
Lampe, Elizabeth
MAartins, Luisa Caricio
Universidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.
author_role author
author2 Almeida, Marcella Kelly Costa de
Santos, Kemper Nunes dos
Freitas, Andrei da Silva
Dantas Socorro de Fátima Loureiro
Costa, Carlos Araújo da
Crescente, ângelo Barlleta
Sousa, Rita Catarina Medeiros de
Brito, Elza Baía de
Nassiri, Reza
Lampe, Elizabeth
MAartins, Luisa Caricio
Universidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fecury, Amanda Alves
Almeida, Marcella Kelly Costa de
Santos, Kemper Nunes dos
Freitas, Andrei da Silva
Dantas Socorro de Fátima Loureiro
Costa, Carlos Araújo da
Crescente, ângelo Barlleta
Sousa, Rita Catarina Medeiros de
Brito, Elza Baía de
Nassiri, Reza
Lampe, Elizabeth
MAartins, Luisa Caricio
Universidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.
dc.subject.en.en.fl_str_mv Histopathology
Genotype
Hepatitis C virus
topic Histopathology
Genotype
Hepatitis C virus
Ciências Biológicas
Hepatite C
Genótipo
dc.subject.decs.pt_BR.fl_str_mv Ciências Biológicas
Hepatite C
Genótipo
description Universidade Federal do Pará. Núcleo de Medicina Tropical. Laboratório de Patologia Clínica das Doenças Tropicais. Belém, PA, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-04-06T17:18:22Z
dc.date.available.fl_str_mv 2015-04-06T17:18:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FECURY, A. A.; et al. Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis c infection. Sociedade Brasileira de Medicina Tropical. Revista, v.47, n.1, p. 90-92,2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9896
dc.identifier.issn.pt_BR.fl_str_mv 16789849
dc.identifier.doi.pt_BR.fl_str_mv DOI:10.1590/0037-8682-0008-2012
identifier_str_mv FECURY, A. A.; et al. Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis c infection. Sociedade Brasileira de Medicina Tropical. Revista, v.47, n.1, p. 90-92,2014.
16789849
DOI:10.1590/0037-8682-0008-2012
url https://www.arca.fiocruz.br/handle/icict/9896
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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