Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection

Detalhes bibliográficos
Autor(a) principal: Fecury,Amanda Alves
Data de Publicação: 2014
Outros Autores: Almeida,Marcella Kelly Costa de, Santos,Kemper Nunes dos, Freitas,Andrei da Silva, Dantas,Socorro de Fátima Loureiro, Costa,Carlos Araújo da, Crescente,Ângelo Barlleta, Sousa,Rita Catarina Medeiros de, Brito,Elza Baía de, Nassiri,Reza, Lampe,Elizabeth, Martins,Luisa Caricio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000100090
Resumo: Introduction: The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression. Methods: Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation. Results: Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis. Conclusions: HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction.
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spelling Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infectionHepatitis C virusGenotypeHistopathology Introduction: The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression. Methods: Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation. Results: Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis. Conclusions: HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction. Sociedade Brasileira de Medicina Tropical - SBMT2014-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000100090Revista da Sociedade Brasileira de Medicina Tropical v.47 n.1 2014reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0008-2012info:eu-repo/semantics/openAccessFecury,Amanda AlvesAlmeida,Marcella Kelly Costa deSantos,Kemper Nunes dosFreitas,Andrei da SilvaDantas,Socorro de Fátima LoureiroCosta,Carlos Araújo daCrescente,Ângelo BarlletaSousa,Rita Catarina Medeiros deBrito,Elza Baía deNassiri,RezaLampe,ElizabethMartins,Luisa Caricioeng2014-05-15T00:00:00Zoai:scielo:S0037-86822014000100090Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2014-05-15T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
title Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
spellingShingle Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
Fecury,Amanda Alves
Hepatitis C virus
Genotype
Histopathology
title_short Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
title_full Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
title_fullStr Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
title_full_unstemmed Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
title_sort Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection
author Fecury,Amanda Alves
author_facet Fecury,Amanda Alves
Almeida,Marcella Kelly Costa de
Santos,Kemper Nunes dos
Freitas,Andrei da Silva
Dantas,Socorro de Fátima Loureiro
Costa,Carlos Araújo da
Crescente,Ângelo Barlleta
Sousa,Rita Catarina Medeiros de
Brito,Elza Baía de
Nassiri,Reza
Lampe,Elizabeth
Martins,Luisa Caricio
author_role author
author2 Almeida,Marcella Kelly Costa de
Santos,Kemper Nunes dos
Freitas,Andrei da Silva
Dantas,Socorro de Fátima Loureiro
Costa,Carlos Araújo da
Crescente,Ângelo Barlleta
Sousa,Rita Catarina Medeiros de
Brito,Elza Baía de
Nassiri,Reza
Lampe,Elizabeth
Martins,Luisa Caricio
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fecury,Amanda Alves
Almeida,Marcella Kelly Costa de
Santos,Kemper Nunes dos
Freitas,Andrei da Silva
Dantas,Socorro de Fátima Loureiro
Costa,Carlos Araújo da
Crescente,Ângelo Barlleta
Sousa,Rita Catarina Medeiros de
Brito,Elza Baía de
Nassiri,Reza
Lampe,Elizabeth
Martins,Luisa Caricio
dc.subject.por.fl_str_mv Hepatitis C virus
Genotype
Histopathology
topic Hepatitis C virus
Genotype
Histopathology
description Introduction: The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression. Methods: Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation. Results: Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis. Conclusions: HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction.
publishDate 2014
dc.date.none.fl_str_mv 2014-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000100090
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000100090
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0037-8682-0008-2012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.47 n.1 2014
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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