Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice

Detalhes bibliográficos
Autor(a) principal: Barral Netto, Manoel
Data de Publicação: 1987
Outros Autores: Freitas, Luiz Antonio Rodrigues de, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7624
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
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spelling Barral Netto, ManoelFreitas, Luiz Antonio Rodrigues deAndrade, Zilton de Araújo2014-05-14T14:27:01Z2014-05-14T14:27:01Z1987ABARRAL-NETTO, M. et al. Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice. American Journal of Pathology, v. 127, n. 2, 1987.0002-9440https://www.arca.fiocruz.br/handle/icict/7624engAmerican Association of PathologistsHistopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHighly susceptible BALB/c mice became partially resistant to Leishmania mexicana amazonensis infection after intravenous immunization with solubilized homologous promastigote antigen. Immunized BALB/c mice exhibited mixed mononuclear cell reactions, with granulomatous inflammation, collagen deposition, and fibrinoid necrosis at the site of infection. In contrast, naive animals displayed a monomorphic picture composed of largely vacuolated and parasitized macrophages with areas of coagulative necrosis. Electron microscopy revealed an increased number of eosinophils, sometimes in close contact with parasitized macrophages, in immunized animals. These findings illustrate that histologic changes reflect host immune status in cutaneous leishmaniasis, and that susceptibility of BALB/c mice to L m amazonensis, although dependent on genetic background, can be artificially modified.Antígenos de Protozoários/imunologiaLeishmaniose/patologiaAnimaisHipersensibilidade TardiaLeishmania mexicana/imunologiaLeishmaniose/imunologiaMacrófagos/patologiaCamundongosCamundongos Endogâmicos BALB CMicroscopia EletrônicaLinfócitos T/imunologiaVacinaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBarral-Netto Histopathological changes....pdfBarral-Netto Histopathological changes....pdfapplication/pdf2457886https://www.arca.fiocruz.br/bitstream/icict/7624/1/Barral-Netto%20Histopathological%20changes....pdf70b8ecb5bc3176843ad39ae3a72a4d15MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7624/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBarral-Netto Histopathological changes....pdf.txtBarral-Netto Histopathological changes....pdf.txtExtracted texttext/plain23600https://www.arca.fiocruz.br/bitstream/icict/7624/5/Barral-Netto%20Histopathological%20changes....pdf.txt04a024f0fd589fc638e9bda168b3e3d6MD55THUMBNAILBarral-Netto Histopathological changes....pdf.jpgBarral-Netto Histopathological changes....pdf.jpgGenerated Thumbnailimage/jpeg2455https://www.arca.fiocruz.br/bitstream/icict/7624/4/Barral-Netto%20Histopathological%20changes....pdf.jpgbabb0cdd48cd31b27d3d6968ff6e5f7dMD54icict/76242023-03-15 14:33:18.787oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice
title Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice
spellingShingle Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice
Barral Netto, Manoel
Antígenos de Protozoários/imunologia
Leishmaniose/patologia
Animais
Hipersensibilidade Tardia
Leishmania mexicana/imunologia
Leishmaniose/imunologia
Macrófagos/patologia
Camundongos
Camundongos Endogâmicos BALB C
Microscopia Eletrônica
Linfócitos T/imunologia
Vacinação
title_short Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice
title_full Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice
title_fullStr Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice
title_full_unstemmed Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice
title_sort Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice
author Barral Netto, Manoel
author_facet Barral Netto, Manoel
Freitas, Luiz Antonio Rodrigues de
Andrade, Zilton de Araújo
author_role author
author2 Freitas, Luiz Antonio Rodrigues de
Andrade, Zilton de Araújo
author2_role author
author
dc.contributor.author.fl_str_mv Barral Netto, Manoel
Freitas, Luiz Antonio Rodrigues de
Andrade, Zilton de Araújo
dc.subject.decs.pt_BR.fl_str_mv Antígenos de Protozoários/imunologia
Leishmaniose/patologia
Animais
Hipersensibilidade Tardia
Leishmania mexicana/imunologia
Leishmaniose/imunologia
Macrófagos/patologia
Camundongos
Camundongos Endogâmicos BALB C
Microscopia Eletrônica
Linfócitos T/imunologia
Vacinação
topic Antígenos de Protozoários/imunologia
Leishmaniose/patologia
Animais
Hipersensibilidade Tardia
Leishmania mexicana/imunologia
Leishmaniose/imunologia
Macrófagos/patologia
Camundongos
Camundongos Endogâmicos BALB C
Microscopia Eletrônica
Linfócitos T/imunologia
Vacinação
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
publishDate 1987
dc.date.issued.fl_str_mv 1987
dc.date.accessioned.fl_str_mv 2014-05-14T14:27:01Z
dc.date.available.fl_str_mv 2014-05-14T14:27:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ABARRAL-NETTO, M. et al. Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice. American Journal of Pathology, v. 127, n. 2, 1987.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7624
dc.identifier.issn.none.fl_str_mv 0002-9440
identifier_str_mv ABARRAL-NETTO, M. et al. Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice. American Journal of Pathology, v. 127, n. 2, 1987.
0002-9440
url https://www.arca.fiocruz.br/handle/icict/7624
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Association of Pathologists
publisher.none.fl_str_mv American Association of Pathologists
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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