Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil

Detalhes bibliográficos
Autor(a) principal: Lago, Barbara V.
Data de Publicação: 2019
Outros Autores: Espirito-Santo, Marcia P. do, Costa, Vanessa D., Marques, Vanessa A., Villar, Livia M., Lewis-Ximenez, Lia L., Lampe, Elisabeth, Mello, Francisco C. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40819
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
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spelling Lago, Barbara V.Espirito-Santo, Marcia P. doCosta, Vanessa D.Marques, Vanessa A.Villar, Livia M.Lewis-Ximenez, Lia L.Lampe, ElisabethMello, Francisco C. A.2020-04-17T13:56:21Z2020-04-17T13:56:21Z2019LAGO, Barbara V. et al. Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil. Viruses, v. 11, n. 869, p. 1-16, Sept. 2019.1999-4915https://www.arca.fiocruz.br/handle/icict/4081910.3390/v110908601999-4915engMDPIVírus da Hepatite BSubgenótiposBrasilHepatitis B virusSubgenotypesBrazilGenetic Diversity of the Hepatitis B Virus Subgenotypes in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, BrasilHepatitis B virus (HBV) subgenotypes may be related to clinical outcomes and response to antiviral therapy. Most Brazilian studies on HBV subgenotypes are restricted to some regions and to specific population groups. Here, we provide an insight about genetic diversity of HBV subgenotypes in 321 serum samples from all five geographical regions, providing a representative overview of their circulation among chronic carriers. Overall, HBV/A1 was the most prevalent subgenotype, being found as the major one in all regions except in South Brazil. Among HBV/D samples, subgenotype D3 was the most prevalent, found in 51.5%, followed by D2 (27.3%) and D4 (21.2%). D2 and D3 were the most prevalent subgenotypes in South region, with high similarity with European strains. D4 was found in North and Northeast region and clustered with strains from Cape Verde and India. For HBV/F, the most frequent subgenotype was F2 (84.1%), followed by F4 (10.1%) and F1 (5.8%), closely related with strains from Venezuela, Argentina and Chile, respectively. Phylogeographic analyses were performed using an HBV full-length genome obtained from samples infected with genotypes rarely found in Brazil (B, C, and E). According to Bayesian inference, HBV/B2 and HBV/C2 were probably introduced in Brazil through China, and HBV/E from Guinea, all of them mostly linked to recent events of human migration. In conclusion, this study provided a comprehensive overview of the current circulation of HBV subgenotypes in Brazil. Our findings might contribute to a better understand of the dynamics of viral variants, to establish a permanent molecular surveillance on the introduction and dispersion patterns of new strains and, thus, to support public policies to control HBV dissemination in Brazil.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40819/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALElisabethLampe_VanessaMarques_etal_IOC_2019.pdfElisabethLampe_VanessaMarques_etal_IOC_2019.pdfapplication/pdf3844931https://www.arca.fiocruz.br/bitstream/icict/40819/2/ElisabethLampe_VanessaMarques_etal_IOC_2019.pdf4342bca08e62743f30bde03359f1a06cMD52TEXTElisabethLampe_VanessaMarques_etal_IOC_2019.pdf.txtElisabethLampe_VanessaMarques_etal_IOC_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil
title Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil
spellingShingle Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil
Lago, Barbara V.
Vírus da Hepatite B
Subgenótipos
Brasil
Hepatitis B virus
Subgenotypes
Brazil
title_short Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil
title_full Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil
title_fullStr Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil
title_full_unstemmed Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil
title_sort Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil
author Lago, Barbara V.
author_facet Lago, Barbara V.
Espirito-Santo, Marcia P. do
Costa, Vanessa D.
Marques, Vanessa A.
Villar, Livia M.
Lewis-Ximenez, Lia L.
Lampe, Elisabeth
Mello, Francisco C. A.
author_role author
author2 Espirito-Santo, Marcia P. do
Costa, Vanessa D.
Marques, Vanessa A.
Villar, Livia M.
Lewis-Ximenez, Lia L.
Lampe, Elisabeth
Mello, Francisco C. A.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lago, Barbara V.
Espirito-Santo, Marcia P. do
Costa, Vanessa D.
Marques, Vanessa A.
Villar, Livia M.
Lewis-Ximenez, Lia L.
Lampe, Elisabeth
Mello, Francisco C. A.
dc.subject.other.pt_BR.fl_str_mv Vírus da Hepatite B
Subgenótipos
Brasil
topic Vírus da Hepatite B
Subgenótipos
Brasil
Hepatitis B virus
Subgenotypes
Brazil
dc.subject.en.pt_BR.fl_str_mv Hepatitis B virus
Subgenotypes
Brazil
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-04-17T13:56:21Z
dc.date.available.fl_str_mv 2020-04-17T13:56:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LAGO, Barbara V. et al. Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil. Viruses, v. 11, n. 869, p. 1-16, Sept. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40819
dc.identifier.issn.pt_BR.fl_str_mv 1999-4915
dc.identifier.doi.none.fl_str_mv 10.3390/v11090860
dc.identifier.eissn.none.fl_str_mv 1999-4915
identifier_str_mv LAGO, Barbara V. et al. Genetic Diversity of the Hepatitis B Virus Subgenotypes in Brazil. Viruses, v. 11, n. 869, p. 1-16, Sept. 2019.
1999-4915
10.3390/v11090860
url https://www.arca.fiocruz.br/handle/icict/40819
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/40819/1/license.txt
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