Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics

Detalhes bibliográficos
Autor(a) principal: Sant’Anna, Thaís B.
Data de Publicação: 2023
Outros Autores: Araujo, Natalia M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59096
Resumo: Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Virologia Molecular e Parasitologia. Rio de Janeiro, RJ, Brasil.
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spelling Sant’Anna, Thaís B.Araujo, Natalia M.2023-06-21T13:19:24Z2023-06-21T13:19:24Z2023Sant`Anna, Thaís; ARAUJO, Natália M. Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics. Microorganisms, v. 11, 1101, p. 1- 14, Apr. 2023.2076-2607https://www.arca.fiocruz.br/handle/icict/5909610.3390/ microorganisms11051101engMDPIVírus da Hepatite BGenótipo DSubgenótiposDistribuição GeográficaMutaçõesEvoluçãoHepatitis B virusGenotype DSubgenotypesGeographic distributionMutationsEvolutionHepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristicsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Virologia Molecular e Parasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Virologia Molecular e Parasitologia. Rio de Janeiro, RJ, Brasil.The hepatitis B virus (HBV) genotype D (HBV/D) is the most extensively distributed genotype worldwide with distinct molecular and epidemiological features. This report provides an up-to-date review on the history of HBV/D subgenotyping and misclassifications, along with largescale analysis of over 1000 HBV/D complete genome sequences, with the aim of gaining a thorough understanding of the global prevalence and geographic distribution of HBV/D subgenotypes. We have additionally explored recent paleogenomic findings, which facilitated the detection of HBV/D genomes dating back to the late Iron Age and provided new perspectives on the origins of modern HBV/D strains. Finally, reports on distinct disease outcomes and responses to antiviral therapy among HBV/D subgenotypes are discussed, further highlighting the complexity of this genotype and the importance of HBV subgenotyping in the management and treatment of hepatitis B.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59096/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALThaisSantana_NataliaAraujo_IOC_2023.pdfThaisSantana_NataliaAraujo_IOC_2023.pdfapplication/pdf1793319https://www.arca.fiocruz.br/bitstream/icict/59096/2/ThaisSantana_NataliaAraujo_IOC_2023.pdfa947aae540db8661d5c4451532f1d278MD52icict/590962023-09-14 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dc.title.en_US.fl_str_mv Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics
title Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics
spellingShingle Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics
Sant’Anna, Thaís B.
Vírus da Hepatite B
Genótipo D
Subgenótipos
Distribuição Geográfica
Mutações
Evolução
Hepatitis B virus
Genotype D
Subgenotypes
Geographic distribution
Mutations
Evolution
title_short Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics
title_full Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics
title_fullStr Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics
title_full_unstemmed Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics
title_sort Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics
author Sant’Anna, Thaís B.
author_facet Sant’Anna, Thaís B.
Araujo, Natalia M.
author_role author
author2 Araujo, Natalia M.
author2_role author
dc.contributor.author.fl_str_mv Sant’Anna, Thaís B.
Araujo, Natalia M.
dc.subject.other.en_US.fl_str_mv Vírus da Hepatite B
Genótipo D
Subgenótipos
Distribuição Geográfica
Mutações
Evolução
topic Vírus da Hepatite B
Genótipo D
Subgenótipos
Distribuição Geográfica
Mutações
Evolução
Hepatitis B virus
Genotype D
Subgenotypes
Geographic distribution
Mutations
Evolution
dc.subject.en.en_US.fl_str_mv Hepatitis B virus
Genotype D
Subgenotypes
Geographic distribution
Mutations
Evolution
description Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Virologia Molecular e Parasitologia. Rio de Janeiro, RJ, Brasil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-06-21T13:19:24Z
dc.date.available.fl_str_mv 2023-06-21T13:19:24Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Sant`Anna, Thaís; ARAUJO, Natália M. Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics. Microorganisms, v. 11, 1101, p. 1- 14, Apr. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59096
dc.identifier.issn.en_US.fl_str_mv 2076-2607
dc.identifier.doi.none.fl_str_mv 10.3390/ microorganisms11051101
identifier_str_mv Sant`Anna, Thaís; ARAUJO, Natália M. Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics. Microorganisms, v. 11, 1101, p. 1- 14, Apr. 2023.
2076-2607
10.3390/ microorganisms11051101
url https://www.arca.fiocruz.br/handle/icict/59096
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/59096/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/59096/2/ThaisSantana_NataliaAraujo_IOC_2023.pdf
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