The subclinical form of experimental visceral leishmaniasis in dogs.

Detalhes bibliográficos
Autor(a) principal: Oliveira, Geraldo Gileno de Sá
Data de Publicação: 1993
Outros Autores: Santoro, Ferrucio, Sadigursky, Moysés
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8475
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
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spelling Oliveira, Geraldo Gileno de SáSantoro, FerrucioSadigursky, Moysés2014-09-30T14:22:58Z2014-09-30T14:22:58Z1993OLIVEIRA, G. G. S.; SANTORO, F.; SADIGURSKY, M. The subclinical form of experimental visceral leishmaniasis in dogs. Memórias do Instituto Oswaldo Cruz, v. 88, n. 2, p. 243-248, 1993.0074-0276https://www.arca.fiocruz.br/handle/icict/8475engFiocruzThe subclinical form of experimental visceral leishmaniasis in dogs.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilCentre d'Immunologie et de Biologie Parasitaire. Unité Mixte UNISERM. Institut Pasteur. Lille, FranceFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilPathological aspects of a subclinical form of experimental canine leishmaniasis is reported here for the first time. Fifteen mongrel dogs were used in the present study. Eight dogs were infected and seven were used as control. Four of the control dogs were inoculated with spleen cells from non-infected hamsters. The eight mongrel dogs inoculated intravenously with amastigotes forms of Leishmania chagasi evolved for periods as long as 25 months without any clinical characteristic sign of classical Visceral Leishmaniasis (VL). Most of the laboratory test results were compatible to those of the seven control animals but culture of bone marrow aspirated material and serologic testing (IIF) demonstrated or provided evidence that the animals were infected. The most important and predominant histopathological lesion in infected animals were epithelioid granulomas presented in the liver, spleen, adrenal gland and lung of some animals. Channels containing erythrocytes in some granulomas of the liver suggest that these granulomas are formed inside sinusoidal capillaries. Despite the animals were proved to be infected and presented characteristic histologic lesions, they did not present external signs of disease. The granulomatous aspect of the lesions indicates a good immunologic reactivity and suggest that a host-parasite equilibrium does exist in the dog experimental model.Leishmania chagasiCanine leishmaniasisSubclinical formHistopathologyDoenças do Cão/patologiaLeishmania infantum/fisiologiaLeishmaniose Visceral/veterináriaAnimaisReservatórios de DoençasCãesFemininoInterações Hospedeiro-ParasitaLeishmania infantum/imunologiaLeishmaniose Visceral/patologiaFígado/patologiaMasculinoBaço/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8475/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALOliveira GGS The subclinical form of experimental....pdfOliveira GGS The subclinical form of experimental....pdfapplication/pdf456875https://www.arca.fiocruz.br/bitstream/icict/8475/2/Oliveira%20GGS%20%20The%20subclinical%20form%20of%20experimental....pdf85f89c418d94770f94da0098e1d33146MD52TEXTOliveira GGS The subclinical form of experimental....pdf.txtOliveira GGS The subclinical form of experimental....pdf.txtExtracted texttext/plain6https://www.arca.fiocruz.br/bitstream/icict/8475/3/Oliveira%20GGS%20%20The%20subclinical%20form%20of%20experimental....pdf.txt6d93d3216dc4a7f5df47d4876fbec4d3MD53icict/84752023-03-15 14:33:24.101oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:24Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The subclinical form of experimental visceral leishmaniasis in dogs.
title The subclinical form of experimental visceral leishmaniasis in dogs.
spellingShingle The subclinical form of experimental visceral leishmaniasis in dogs.
Oliveira, Geraldo Gileno de Sá
Leishmania chagasi
Canine leishmaniasis
Subclinical form
Histopathology
Doenças do Cão/patologia
Leishmania infantum/fisiologia
Leishmaniose Visceral/veterinária
Animais
Reservatórios de Doenças
Cães
Feminino
Interações Hospedeiro-Parasita
Leishmania infantum/imunologia
Leishmaniose Visceral/patologia
Fígado/patologia
Masculino
Baço/patologia
title_short The subclinical form of experimental visceral leishmaniasis in dogs.
title_full The subclinical form of experimental visceral leishmaniasis in dogs.
title_fullStr The subclinical form of experimental visceral leishmaniasis in dogs.
title_full_unstemmed The subclinical form of experimental visceral leishmaniasis in dogs.
title_sort The subclinical form of experimental visceral leishmaniasis in dogs.
author Oliveira, Geraldo Gileno de Sá
author_facet Oliveira, Geraldo Gileno de Sá
Santoro, Ferrucio
Sadigursky, Moysés
author_role author
author2 Santoro, Ferrucio
Sadigursky, Moysés
author2_role author
author
dc.contributor.author.fl_str_mv Oliveira, Geraldo Gileno de Sá
Santoro, Ferrucio
Sadigursky, Moysés
dc.subject.en.pt_BR.fl_str_mv Leishmania chagasi
Canine leishmaniasis
Subclinical form
Histopathology
topic Leishmania chagasi
Canine leishmaniasis
Subclinical form
Histopathology
Doenças do Cão/patologia
Leishmania infantum/fisiologia
Leishmaniose Visceral/veterinária
Animais
Reservatórios de Doenças
Cães
Feminino
Interações Hospedeiro-Parasita
Leishmania infantum/imunologia
Leishmaniose Visceral/patologia
Fígado/patologia
Masculino
Baço/patologia
dc.subject.decs.pt_BR.fl_str_mv Doenças do Cão/patologia
Leishmania infantum/fisiologia
Leishmaniose Visceral/veterinária
Animais
Reservatórios de Doenças
Cães
Feminino
Interações Hospedeiro-Parasita
Leishmania infantum/imunologia
Leishmaniose Visceral/patologia
Fígado/patologia
Masculino
Baço/patologia
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1993
dc.date.issued.fl_str_mv 1993
dc.date.accessioned.fl_str_mv 2014-09-30T14:22:58Z
dc.date.available.fl_str_mv 2014-09-30T14:22:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, G. G. S.; SANTORO, F.; SADIGURSKY, M. The subclinical form of experimental visceral leishmaniasis in dogs. Memórias do Instituto Oswaldo Cruz, v. 88, n. 2, p. 243-248, 1993.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8475
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv OLIVEIRA, G. G. S.; SANTORO, F.; SADIGURSKY, M. The subclinical form of experimental visceral leishmaniasis in dogs. Memórias do Instituto Oswaldo Cruz, v. 88, n. 2, p. 243-248, 1993.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/8475
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fiocruz
publisher.none.fl_str_mv Fiocruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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