Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36714 |
Resumo: | Roberto M. Saraiva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
| id |
CRUZ_209e03b2b53ad7faa4453e94d274ed03 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/36714 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Beigi, FaridehGonzalez, Daniel R.Minhas, Khalid M.Sun, Qi-AnFoster, Matthew W.Khan, Shakil A.Treuer, Adriana V.Dulce, Raul A.Harrison, Robert W.Saraiva, Roberto M.Premer, CourtneySchulman, Ivonne HernandezStamler, Jonathan S.Hare, Joshua M.2019-10-25T14:05:58Z2019-10-25T14:05:58Z2012BEIGI, Farideh et al. Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. Proceedings of the National Academy of Sciences, v. 109, n. 11, p. 4314-4319, Mar. 2012.0027-8424https://www.arca.fiocruz.br/handle/icict/3671410.1073/pnas.11133191091091-6490Roberto M. Saraiva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-04-25University of Miami Miller School of Medicine. Interdisciplinary Stem Cell Institute. Miami, FL, USA.University of Miami Miller School of Medicine. Interdisciplinary Stem Cell Institute. Miami, FL, USA.University of Miami Miller School of Medicine. Interdisciplinary Stem Cell Institute. Miami, FL, USA.Case Western Reserve University. Institute for Transformative Molecular Medicine. Department of Medicine. Cleveland, OH, USA / University Hospitals. Cleveland, OH, USA.Duke University. Department of Medicine. Durham, NC, USA.University of Miami Miller School of Medicine. Interdisciplinary Stem Cell Institute. Miami, FL, USA.University of Miami Miller School of Medicine. Interdisciplinary Stem Cell Institute. Miami, FL, USA.University of Miami Miller School of Medicine. Interdisciplinary Stem Cell Institute. Miami, FL, USA.University of Miami Miller School of Medicine. Interdisciplinary Stem Cell Institute. Miami, FL, USA.University of Miami Miller School of Medicine. Interdisciplinary Stem Cell Institute. Miami, FL, USA.University of Miami Miller School of Medicine. Interdisciplinary Stem Cell Institute. Miami, FL, USA.University of Miami Miller School of Medicine. Interdisciplinary Stem Cell Institute. Miami, FL, USA / Miami Veterans Affairs Healthcare System. Nephrology-Hypertension Section. Miami, FL, USA.Case Western Reserve University. Institute for Transformative Molecular Medicine. Department of Medicine. Cleveland, OH, USA / University Hospitals. Cleveland, OH, USA.University of Miami Miller School of Medicine. Interdisciplinary Stem Cell Institute. Miami, FL, USA.Although protein S-nitrosylation is increasingly recognized as mediating nitric oxide (NO) signaling, roles for protein denitrosylation in physiology remain unknown. Here, we show that S-nitrosoglutathione reductase (GSNOR), an enzyme that governs levels of S-nitrosylation by promoting protein denitrosylation, regulates both peripheral vascular tone and β-adrenergic agonist-stimulated cardiac contractility, previously ascribed exclusively to NO/cGMP. GSNOR-deficient mice exhibited reduced peripheral vascular tone and depressed β-adrenergic inotropic responses that were associated with impaired β-agonist–induced denitrosylation of cardiac ryanodine receptor 2 (RyR2), resulting in calcium leak. These results indicate that systemic hemodynamic responses (vascular tone and cardiac contractility), both under basal conditions and after adrenergic activation, are regulated through concerted actions of NO synthase/GSNOR and that aberrant denitrosylation impairs cardiovascular function. Our findings support the notion that dynamic S-nitrosylation/denitrosylation reactions are essential in cardiovascular regulation.engNational Academy of SciencesDynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular functioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleExcitation-contraction couplingNitroso-redox imbalanceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36714/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Beigi_Farideh_etal_INI_2012.pdfve_Beigi_Farideh_etal_INI_2012.pdfapplication/pdf969617https://www.arca.fiocruz.br/bitstream/icict/36714/2/ve_Beigi_Farideh_etal_INI_2012.pdfbc69f93ac1ddff98601b831f4dad7b05MD52TEXTve_Beigi_Farideh_etal_INI_2012.pdf.txtve_Beigi_Farideh_etal_INI_2012.pdf.txtExtracted texttext/plain41821https://www.arca.fiocruz.br/bitstream/icict/36714/3/ve_Beigi_Farideh_etal_INI_2012.pdf.txt5727c211c7572556551ceb5168682304MD53icict/367142021-03-24 16:32:31.031oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function |
| title |
Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function |
| spellingShingle |
Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function Beigi, Farideh Excitation-contraction coupling Nitroso-redox imbalance |
| title_short |
Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function |
| title_full |
Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function |
| title_fullStr |
Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function |
| title_full_unstemmed |
Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function |
| title_sort |
Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function |
| author |
Beigi, Farideh |
| author_facet |
Beigi, Farideh Gonzalez, Daniel R. Minhas, Khalid M. Sun, Qi-An Foster, Matthew W. Khan, Shakil A. Treuer, Adriana V. Dulce, Raul A. Harrison, Robert W. Saraiva, Roberto M. Premer, Courtney Schulman, Ivonne Hernandez Stamler, Jonathan S. Hare, Joshua M. |
| author_role |
author |
| author2 |
Gonzalez, Daniel R. Minhas, Khalid M. Sun, Qi-An Foster, Matthew W. Khan, Shakil A. Treuer, Adriana V. Dulce, Raul A. Harrison, Robert W. Saraiva, Roberto M. Premer, Courtney Schulman, Ivonne Hernandez Stamler, Jonathan S. Hare, Joshua M. |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Beigi, Farideh Gonzalez, Daniel R. Minhas, Khalid M. Sun, Qi-An Foster, Matthew W. Khan, Shakil A. Treuer, Adriana V. Dulce, Raul A. Harrison, Robert W. Saraiva, Roberto M. Premer, Courtney Schulman, Ivonne Hernandez Stamler, Jonathan S. Hare, Joshua M. |
| dc.subject.en.pt_BR.fl_str_mv |
Excitation-contraction coupling Nitroso-redox imbalance |
| topic |
Excitation-contraction coupling Nitroso-redox imbalance |
| description |
Roberto M. Saraiva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
| publishDate |
2012 |
| dc.date.issued.fl_str_mv |
2012 |
| dc.date.accessioned.fl_str_mv |
2019-10-25T14:05:58Z |
| dc.date.available.fl_str_mv |
2019-10-25T14:05:58Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
BEIGI, Farideh et al. Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. Proceedings of the National Academy of Sciences, v. 109, n. 11, p. 4314-4319, Mar. 2012. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/36714 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0027-8424 |
| dc.identifier.doi.none.fl_str_mv |
10.1073/pnas.1113319109 |
| dc.identifier.eissn.none.fl_str_mv |
1091-6490 |
| identifier_str_mv |
BEIGI, Farideh et al. Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. Proceedings of the National Academy of Sciences, v. 109, n. 11, p. 4314-4319, Mar. 2012. 0027-8424 10.1073/pnas.1113319109 1091-6490 |
| url |
https://www.arca.fiocruz.br/handle/icict/36714 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
National Academy of Sciences |
| publisher.none.fl_str_mv |
National Academy of Sciences |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/36714/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/36714/2/ve_Beigi_Farideh_etal_INI_2012.pdf https://www.arca.fiocruz.br/bitstream/icict/36714/3/ve_Beigi_Farideh_etal_INI_2012.pdf.txt |
| bitstream.checksum.fl_str_mv |
8a4605be74aa9ea9d79846c1fba20a33 bc69f93ac1ddff98601b831f4dad7b05 5727c211c7572556551ceb5168682304 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324698114686976 |